Disruption of the CRF1 receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice

Disruption of the CRF1 receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice

Substance-induced social behavior deficits dramatically worsen the clinical outcome of substance use disorders; yet, the underlying mechanisms remain poorly understood. Herein, we investigated the role for the corticotropin-releasing factor receptor 1 (CRF1) in the acute sociability deficits induced...

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Bibliographic Details
Main Authors: Alessandro Piccin, Anne-Emilie Allain, Jérôme M Baufreton, Sandrine S Bertrand, Angelo Contarino
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
CRF system
sociability deficit
morphine
CRF1 receptor
pharmacology
genetics
Online Access:https://elifesciences.org/articles/100849
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