Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity.
To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs' functions according to body mass ind...
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2021-01-01
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| author | Marie-Agnès Dragon-Durey Xiaoyi Chen Amos Kirilovsky Nadine Ben Hamouda Carine El Sissy Jules Russick Etienne Charpentier Yannick Binois Florence Marliot Maxime Meylan Clémence Granier Hélène Pere Antonin Saldmann Bastien Rance Anne Sophie Jannot Stéphanie Baron Mouna Chebbi Antoine Fayol Nathalie Josseaume Claire Rives-Lange Pierre-Louis Tharaux Bernard Cholley Jean-Luc Diehl Jean-Benoît Arlet Michel Azizi Alexandre Karras Sébastien Czernichow David M Smadja Jean-Sébastien Hulot Isabelle Cremer Eric Tartour Elie Mousseaux Franck Pagès |
| author_facet | Marie-Agnès Dragon-Durey Xiaoyi Chen Amos Kirilovsky Nadine Ben Hamouda Carine El Sissy Jules Russick Etienne Charpentier Yannick Binois Florence Marliot Maxime Meylan Clémence Granier Hélène Pere Antonin Saldmann Bastien Rance Anne Sophie Jannot Stéphanie Baron Mouna Chebbi Antoine Fayol Nathalie Josseaume Claire Rives-Lange Pierre-Louis Tharaux Bernard Cholley Jean-Luc Diehl Jean-Benoît Arlet Michel Azizi Alexandre Karras Sébastien Czernichow David M Smadja Jean-Sébastien Hulot Isabelle Cremer Eric Tartour Elie Mousseaux Franck Pagès |
| author_sort | Marie-Agnès Dragon-Durey |
| collection | DOAJ |
| description | To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs' functions according to body mass index (BMI) categories. High-dimensional flow cytometric characterization of immune cell subsets was performed at admission, 30 systemic cytokines/chemokines levels were sequentially measured, thirteen endothelial markers were determined at admission and at the zenith of the cytokines. Computed tomography scans on admission were quantified for lung damage and hepatic steatosis (n = 23). Abnormal BMI (> 25) observed in 72.6% of patients, was associated with a higher rate of intensive care unit hospitalization (p = 0.044). SARS-CoV-2 RNAaemia, peripheral immune cell subsets and cytokines/chemokines were similar among BMI groups. A significant association between inflammatory cytokines and liver, renal, and endothelial dysfunctions was observed only in patients with obesity (BMI > 30). In contrast, early signs of lung damage (ground-glass opacity) correlated with Th1/M1/inflammatory cytokines only in normal weight patients. Later lesions of pulmonary consolidation correlated with BMI but were independent of cytokine levels. Our study reveals distinct physiopathological mechanisms associated with SARS-CoV-2 infection in patients with obesity that may have important clinical implications. |
| format | Article |
| id | doaj-art-aed42d7be3aa438b9d2fda28586978be |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-aed42d7be3aa438b9d2fda28586978be2025-08-20T02:17:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01165e025202610.1371/journal.pone.0252026Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity.Marie-Agnès Dragon-DureyXiaoyi ChenAmos KirilovskyNadine Ben HamoudaCarine El SissyJules RussickEtienne CharpentierYannick BinoisFlorence MarliotMaxime MeylanClémence GranierHélène PereAntonin SaldmannBastien RanceAnne Sophie JannotStéphanie BaronMouna ChebbiAntoine FayolNathalie JosseaumeClaire Rives-LangePierre-Louis TharauxBernard CholleyJean-Luc DiehlJean-Benoît ArletMichel AziziAlexandre KarrasSébastien CzernichowDavid M SmadjaJean-Sébastien HulotIsabelle CremerEric TartourElie MousseauxFranck PagèsTo investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs' functions according to body mass index (BMI) categories. High-dimensional flow cytometric characterization of immune cell subsets was performed at admission, 30 systemic cytokines/chemokines levels were sequentially measured, thirteen endothelial markers were determined at admission and at the zenith of the cytokines. Computed tomography scans on admission were quantified for lung damage and hepatic steatosis (n = 23). Abnormal BMI (> 25) observed in 72.6% of patients, was associated with a higher rate of intensive care unit hospitalization (p = 0.044). SARS-CoV-2 RNAaemia, peripheral immune cell subsets and cytokines/chemokines were similar among BMI groups. A significant association between inflammatory cytokines and liver, renal, and endothelial dysfunctions was observed only in patients with obesity (BMI > 30). In contrast, early signs of lung damage (ground-glass opacity) correlated with Th1/M1/inflammatory cytokines only in normal weight patients. Later lesions of pulmonary consolidation correlated with BMI but were independent of cytokine levels. Our study reveals distinct physiopathological mechanisms associated with SARS-CoV-2 infection in patients with obesity that may have important clinical implications.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0252026&type=printable |
| spellingShingle | Marie-Agnès Dragon-Durey Xiaoyi Chen Amos Kirilovsky Nadine Ben Hamouda Carine El Sissy Jules Russick Etienne Charpentier Yannick Binois Florence Marliot Maxime Meylan Clémence Granier Hélène Pere Antonin Saldmann Bastien Rance Anne Sophie Jannot Stéphanie Baron Mouna Chebbi Antoine Fayol Nathalie Josseaume Claire Rives-Lange Pierre-Louis Tharaux Bernard Cholley Jean-Luc Diehl Jean-Benoît Arlet Michel Azizi Alexandre Karras Sébastien Czernichow David M Smadja Jean-Sébastien Hulot Isabelle Cremer Eric Tartour Elie Mousseaux Franck Pagès Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity. PLoS ONE |
| title | Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity. |
| title_full | Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity. |
| title_fullStr | Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity. |
| title_full_unstemmed | Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity. |
| title_short | Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity. |
| title_sort | differential association between inflammatory cytokines and multiorgan dysfunction in covid 19 patients with obesity |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0252026&type=printable |
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