Analysis of the efficacy of aspiration combined with venous sinus intraluminal thrombolysis for severe cerebral venous sinus thrombosis
Objective To examine the safety and efficacy of catheter aspiration combined with microcatheter venous sinus intraluminal thrombolysis in the treatment of severe cerebral venous sinus thrombosis (CVST). Methods and Results We retrospectively analyzed the medical records of 10 patients with severe CV...
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Tianjin Huanhu Hospital
2025-06-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/3046 |
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| author | ZHANG Jing GE Han-ming HAN Nan-nan ZHANG Le-shi LIU Zhi-qin CHANG Ming-ze |
| author_facet | ZHANG Jing GE Han-ming HAN Nan-nan ZHANG Le-shi LIU Zhi-qin CHANG Ming-ze |
| author_sort | ZHANG Jing |
| collection | DOAJ |
| description | Objective To examine the safety and efficacy of catheter aspiration combined with microcatheter venous sinus intraluminal thrombolysis in the treatment of severe cerebral venous sinus thrombosis (CVST). Methods and Results We retrospectively analyzed the medical records of 10 patients with severe CVST who received catheter aspiration combined with microcatheter venous sinus intraluminal thrombolysis at The Affiliated Hospital of Northwest University, Xi'an No. 3 Hospital from January 2017 to December 2022. All 10 patients successfully completed the surgery. One patient achieved complete recanalization of the venous sinus immediately after the operation, 5 patients achieved partial recanalization, and 4 patients didn't recanalize. At the 90 d after the surgery, 5 patients achieved complete recanalization, 4 patients achieved partial recanalization, and one patient didn't recanalize. Among 7 patients who had intracranial hemorrhage (ICH) before the operation, head CT reexamination 7 d after the operation showed the hemorrhage at the original position was absorbed compared with that before the operation. Two patients developed newly ICH within 7 d after the operation. One patient experienced a poor prognosis [modified Rankin Scale (mRS) score of 3], while 9 had favorable prognosis (mRS ≤ 2) at 90 d after the operation. At the 12-month follow-up after the operation, all 10 patients had a favorable prognosis. Conclusions Catheter aspiration combined with microcatheter venous sinus intraluminal thrombolysis maybe a safe and effective treatment for severe CVST, showing improvement in prognosis. |
| format | Article |
| id | doaj-art-aed408e9fffe4f1f9a3efe6dea3574ee |
| institution | DOAJ |
| issn | 1672-6731 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj-art-aed408e9fffe4f1f9a3efe6dea3574ee2025-08-20T03:15:43ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312025-06-0125648949510.3969/j.issn.1672⁃6731.2025.06.006Analysis of the efficacy of aspiration combined with venous sinus intraluminal thrombolysis for severe cerebral venous sinus thrombosisZHANG Jing0GE Han-ming1HAN Nan-nan2ZHANG Le-shi3LIU Zhi-qin4CHANG Ming-ze5Department of Neurology, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an 710018, Shaanxi, ChinaDepartment of Neurology, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an 710018, Shaanxi, ChinaDepartment of Neurology, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an 710018, Shaanxi, ChinaDepartment of Neurology, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an 710018, Shaanxi, ChinaDepartment of Neurology, Xi'an Central Hospital, Xi'an 710003, Shaanxi, ChinaDepartment of Neurology, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an 710018, Shaanxi, ChinaObjective To examine the safety and efficacy of catheter aspiration combined with microcatheter venous sinus intraluminal thrombolysis in the treatment of severe cerebral venous sinus thrombosis (CVST). Methods and Results We retrospectively analyzed the medical records of 10 patients with severe CVST who received catheter aspiration combined with microcatheter venous sinus intraluminal thrombolysis at The Affiliated Hospital of Northwest University, Xi'an No. 3 Hospital from January 2017 to December 2022. All 10 patients successfully completed the surgery. One patient achieved complete recanalization of the venous sinus immediately after the operation, 5 patients achieved partial recanalization, and 4 patients didn't recanalize. At the 90 d after the surgery, 5 patients achieved complete recanalization, 4 patients achieved partial recanalization, and one patient didn't recanalize. Among 7 patients who had intracranial hemorrhage (ICH) before the operation, head CT reexamination 7 d after the operation showed the hemorrhage at the original position was absorbed compared with that before the operation. Two patients developed newly ICH within 7 d after the operation. One patient experienced a poor prognosis [modified Rankin Scale (mRS) score of 3], while 9 had favorable prognosis (mRS ≤ 2) at 90 d after the operation. At the 12-month follow-up after the operation, all 10 patients had a favorable prognosis. Conclusions Catheter aspiration combined with microcatheter venous sinus intraluminal thrombolysis maybe a safe and effective treatment for severe CVST, showing improvement in prognosis.http://www.cjcnn.org/index.php/cjcnn/article/view/3046sinus thrombosis， intracranialcritical illnessthrombectomythrombolytic therapyprognosis |
| spellingShingle | ZHANG Jing GE Han-ming HAN Nan-nan ZHANG Le-shi LIU Zhi-qin CHANG Ming-ze Analysis of the efficacy of aspiration combined with venous sinus intraluminal thrombolysis for severe cerebral venous sinus thrombosis Chinese Journal of Contemporary Neurology and Neurosurgery sinus thrombosis， intracranial critical illness thrombectomy thrombolytic therapy prognosis |
| title | Analysis of the efficacy of aspiration combined with venous sinus intraluminal thrombolysis for severe cerebral venous sinus thrombosis |
| title_full | Analysis of the efficacy of aspiration combined with venous sinus intraluminal thrombolysis for severe cerebral venous sinus thrombosis |
| title_fullStr | Analysis of the efficacy of aspiration combined with venous sinus intraluminal thrombolysis for severe cerebral venous sinus thrombosis |
| title_full_unstemmed | Analysis of the efficacy of aspiration combined with venous sinus intraluminal thrombolysis for severe cerebral venous sinus thrombosis |
| title_short | Analysis of the efficacy of aspiration combined with venous sinus intraluminal thrombolysis for severe cerebral venous sinus thrombosis |
| title_sort | analysis of the efficacy of aspiration combined with venous sinus intraluminal thrombolysis for severe cerebral venous sinus thrombosis |
| topic | sinus thrombosis， intracranial critical illness thrombectomy thrombolytic therapy prognosis |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/3046 |
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