The prognosis prediction value of CD69+ CD8+ tissue-resident memory T cell as a novel indicator of pathologic complete response heterogeneity following different neoadjuvant therapy regimen in esophageal squamous cell carcinoma

The prognosis prediction value of CD69+ CD8+ tissue-resident memory T cell as a novel indicator of pathologic complete response heterogeneity following different neoadjuvant therapy regimen in esophageal squamous cell carcinoma

Abstract Background Improving pathological complete response (pCR) rate is currently the main goal of neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma (LA-ESCC). However, improved pCR rates do not consistently translate into better prognosis, likely due to regimen-specific...

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Main Authors: Ao Liu, Defeng Liu, Xiuli Liu, Yuxiang Chi, Longxiang Guo, Dianxing Li, Qiankun Wang, Yuanlin Li, Yi Li, Guiwen Zheng, Haiqun Lin, Qiuan Yang, Yaru Tian, Jinming Yu, Minghuan Li
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Esophageal squamous cell carcinoma
Neoadjuvant
pCR
Immunotherapy
Tissue-resident memory T cell
Online Access:https://doi.org/10.1007/s00262-025-03988-3
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https://doi.org/10.1007/s00262-025-03988-3

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