SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY
Introduction: Sickle cell trait (SCT) is an autosomal recessive blood disorder in which patients are heterozygous carriers for hemoglobin S (HbAS) and are usually asymptomatic. We performed a descriptive analysis of clinical manifestations and outcomes associated with SCT. Methods: This was a de...
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PAGEPress Publications
2023-02-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/5137 |
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| author | Diego A Vargas-Hernández Adriana Catalina Uscategui-Ruiz Andrés Jesus Prada-Rueda Consuelo Romero-Sánchez |
| author_facet | Diego A Vargas-Hernández Adriana Catalina Uscategui-Ruiz Andrés Jesus Prada-Rueda Consuelo Romero-Sánchez |
| author_sort | Diego A Vargas-Hernández |
| collection | DOAJ |
| description |
Introduction: Sickle cell trait (SCT) is an autosomal recessive blood disorder in which patients are heterozygous carriers for hemoglobin S (HbAS) and are usually asymptomatic. We performed a descriptive analysis of clinical manifestations and outcomes associated with SCT.
Methods: This was a descriptive, cross-sectional study that included patients with SCT from 2014 to 2020 at Hospital Militar Central, the reference center of the Military forces in Bogota, Colombia.
Results: Of 647 hemoglobin electrophoresis analyzed, we identified 51 patients with SCT, including 43 males (84.3%) and eight females (15.7%), with a median age of 22 years (IQR 15–36 years). Of these, 28 (54.8%) were Afro-Colombian, and 23 (45.1%) were Colombian mestizos. Twenty-four patients (47.1%) were asymptomatic, and Twenty-seven patients (52.9%) were symptomatic (systemic complications); splenic complications were the most important (85.2%), p=0.0005, and there was a wide spectrum of splenic complications. We found significant elevations in leukocytes, bilirubin, LDH, and CRP. Eighteen patients (66.7%) received medical management, five patients (18.5%) required splenectomy, and only 5.9% of patients were sent for genetic counseling.
Conclusions: Splenic complications were the most relevant in symptomatic patients. Most patients received medical treatment, and 18.5% of patients required splenectomy. Our results reflect the absence of redirection of these patients to genetic counseling.
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| format | Article |
| id | doaj-art-aeba906729c048f9becd404fe684efd8 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-aeba906729c048f9becd404fe684efd82025-01-02T23:11:06ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062023-02-0115110.4084/MJHID.2023.015SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDYDiego A Vargas-Hernández0Adriana Catalina Uscategui-Ruiz1Andrés Jesus Prada-Rueda 2Consuelo Romero-Sánchez3Hospital Militar Central, Department of Internal Medicine, Tv 3 No 49-00 Bogotá, CO 110231 3598888 Universidad Militar Nueva Granada, Medical School Bogota, CO, 6500000Hospital Militar Central, Department of Internal Medicine, Tv 3 No 49-00 Bogotá, CO 110231 3598888 Universidad Militar Nueva Granada, Medical School Bogota, CO, 6500000.Hospital Militar Central, Department of Internal Medicine, Tv 3 No 49-00 Bogotá, CO 110231 3598888 Universidad Militar Nueva Granada, Medical School Bogota, CO, 6500000Hospital Militar Central, Rheumatology and Immunology Department/Clinical Immunology Group Tv 3 No 49-00 Bogotá, CO 3598888 Universidad El Bosque, Cellular and Molecular Immunology Group/INMUBO, Av. Carrera 9 # 131A-02 Bogota, CO 6763110 Introduction: Sickle cell trait (SCT) is an autosomal recessive blood disorder in which patients are heterozygous carriers for hemoglobin S (HbAS) and are usually asymptomatic. We performed a descriptive analysis of clinical manifestations and outcomes associated with SCT. Methods: This was a descriptive, cross-sectional study that included patients with SCT from 2014 to 2020 at Hospital Militar Central, the reference center of the Military forces in Bogota, Colombia. Results: Of 647 hemoglobin electrophoresis analyzed, we identified 51 patients with SCT, including 43 males (84.3%) and eight females (15.7%), with a median age of 22 years (IQR 15–36 years). Of these, 28 (54.8%) were Afro-Colombian, and 23 (45.1%) were Colombian mestizos. Twenty-four patients (47.1%) were asymptomatic, and Twenty-seven patients (52.9%) were symptomatic (systemic complications); splenic complications were the most important (85.2%), p=0.0005, and there was a wide spectrum of splenic complications. We found significant elevations in leukocytes, bilirubin, LDH, and CRP. Eighteen patients (66.7%) received medical management, five patients (18.5%) required splenectomy, and only 5.9% of patients were sent for genetic counseling. Conclusions: Splenic complications were the most relevant in symptomatic patients. Most patients received medical treatment, and 18.5% of patients required splenectomy. Our results reflect the absence of redirection of these patients to genetic counseling. http://www.mjhid.org/index.php/mjhid/article/view/5137Sickle Cell TraitSplenic InfarctionSplenic DiseasesSpleenHemoglobinopathies |
| spellingShingle | Diego A Vargas-Hernández Adriana Catalina Uscategui-Ruiz Andrés Jesus Prada-Rueda Consuelo Romero-Sánchez SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY Mediterranean Journal of Hematology and Infectious Diseases Sickle Cell Trait Splenic Infarction Splenic Diseases Spleen Hemoglobinopathies |
| title | SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY |
| title_full | SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY |
| title_fullStr | SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY |
| title_full_unstemmed | SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY |
| title_short | SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY |
| title_sort | sickle cell trait clinical manifestations and outcomes a cross sectional study |
| topic | Sickle Cell Trait Splenic Infarction Splenic Diseases Spleen Hemoglobinopathies |
| url | http://www.mjhid.org/index.php/mjhid/article/view/5137 |
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