Kappa Free Light Chains in Multiple Sclerosis as a Marker of Intrathecal Humoral Response: A Sex-Disaggregated Study

Kappa Free Light Chains in Multiple Sclerosis as a Marker of Intrathecal Humoral Response: A Sex-Disaggregated Study

Background: Kappa free light chains (KFLCs) are emerging as promising biomarkers for intrathecal B cell activity for diagnosing multiple sclerosis (MS) through cerebrospinal fluid (CSF) analysis. In this study, we evaluated the ability of KFLC formulas to identify the presence of MS and their agreem...

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Main Authors: Raffaella Candeloro, Maila Galloppa, Laura Lombardo, Michele Laudisi, Sara Ghisellini, Giovanna Negri, Caterina Ferri, Carla Marcialis, Tiziana Bellini, Maura Pugliatti, Massimiliano Castellazzi
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Diagnostics
Subjects:
multiple sclerosis
cerebrospinal fluid
intrathecal synthesis
kappa free light chains
sex differences
Online Access:https://www.mdpi.com/2075-4418/14/24/2798
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