Metabolic syndrome and bladder carcinoma ‒ A cross-sectional study
Background and Objective: Urinary bladder carcinoma is one of the most common carcinomas of the genitourinary tract. Smoking and male sex being an established etiological factor for bladder carcinoma, the rising incidence is seen in nonsmokers as well as in females suggesting other probable etiologi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-05-01
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| Series: | Annals of Medical Science and Research |
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| Online Access: | https://journals.lww.com/10.4103/amsr.amsr_8_22 |
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| author | Soumya Mondal Eeshansh Khare Dilip Kumar Pal |
| author_facet | Soumya Mondal Eeshansh Khare Dilip Kumar Pal |
| author_sort | Soumya Mondal |
| collection | DOAJ |
| description | Background and Objective:
Urinary bladder carcinoma is one of the most common carcinomas of the genitourinary tract. Smoking and male sex being an established etiological factor for bladder carcinoma, the rising incidence is seen in nonsmokers as well as in females suggesting other probable etiologies such as metabolic syndrome. Our intention was to know the association between metabolic syndrome and the risk of urinary bladder carcinoma and its histopathological grading.
Materials and Methods:
A retrospective cross-sectional study of 201 patients was performed after ethics clearance in a tertiary care hospital in India, between June 1, 2017, and May 31, 2019. The data of patients of urothelial carcinoma bladder were divided into two groups based on the presence or absence of metabolic syndrome and its associated variables for comparison and evaluation.
Results:
Of the total 201 patients, 15 patients had metabolic syndrome. In metabolic syndrome patients, ten patients had high-grade tumors and five patients had low-grade tumors. Moreover, in metabolic syndrome negative patients, 145 were of low grade and 41 were of high grade. Body mass index >30, triglyceride levels >150 mg/dL, and high-density lipoprotein level <40 mg/dL were mostly present in patients of metabolic syndrome, and its association was statistically significant.
Interpretation and Conclusion:
Metabolic syndrome is associated with high-grade urothelial carcinoma of the bladder. Hence, patients with the risk factors for metabolic syndrome and without urinary symptoms should be properly screened for bladder cancer as there may be bladder carcinoma in the early stage and its timely diagnosis and intervention can prolong the survival of these patients. |
| format | Article |
| id | doaj-art-aeb4dbc1bd934cb29fa2b3f4e57b0336 |
| institution | Kabale University |
| issn | 2949-785X |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Medical Science and Research |
| spelling | doaj-art-aeb4dbc1bd934cb29fa2b3f4e57b03362025-08-20T03:39:15ZengWolters Kluwer Medknow PublicationsAnnals of Medical Science and Research2949-785X2022-05-0112697310.4103/amsr.amsr_8_22Metabolic syndrome and bladder carcinoma ‒ A cross-sectional studySoumya MondalEeshansh KhareDilip Kumar PalBackground and Objective: Urinary bladder carcinoma is one of the most common carcinomas of the genitourinary tract. Smoking and male sex being an established etiological factor for bladder carcinoma, the rising incidence is seen in nonsmokers as well as in females suggesting other probable etiologies such as metabolic syndrome. Our intention was to know the association between metabolic syndrome and the risk of urinary bladder carcinoma and its histopathological grading. Materials and Methods: A retrospective cross-sectional study of 201 patients was performed after ethics clearance in a tertiary care hospital in India, between June 1, 2017, and May 31, 2019. The data of patients of urothelial carcinoma bladder were divided into two groups based on the presence or absence of metabolic syndrome and its associated variables for comparison and evaluation. Results: Of the total 201 patients, 15 patients had metabolic syndrome. In metabolic syndrome patients, ten patients had high-grade tumors and five patients had low-grade tumors. Moreover, in metabolic syndrome negative patients, 145 were of low grade and 41 were of high grade. Body mass index >30, triglyceride levels >150 mg/dL, and high-density lipoprotein level <40 mg/dL were mostly present in patients of metabolic syndrome, and its association was statistically significant. Interpretation and Conclusion: Metabolic syndrome is associated with high-grade urothelial carcinoma of the bladder. Hence, patients with the risk factors for metabolic syndrome and without urinary symptoms should be properly screened for bladder cancer as there may be bladder carcinoma in the early stage and its timely diagnosis and intervention can prolong the survival of these patients.https://journals.lww.com/10.4103/amsr.amsr_8_22metabolic syndromeobesityurothelial carcinoma |
| spellingShingle | Soumya Mondal Eeshansh Khare Dilip Kumar Pal Metabolic syndrome and bladder carcinoma ‒ A cross-sectional study Annals of Medical Science and Research metabolic syndrome obesity urothelial carcinoma |
| title | Metabolic syndrome and bladder carcinoma ‒ A cross-sectional study |
| title_full | Metabolic syndrome and bladder carcinoma ‒ A cross-sectional study |
| title_fullStr | Metabolic syndrome and bladder carcinoma ‒ A cross-sectional study |
| title_full_unstemmed | Metabolic syndrome and bladder carcinoma ‒ A cross-sectional study |
| title_short | Metabolic syndrome and bladder carcinoma ‒ A cross-sectional study |
| title_sort | metabolic syndrome and bladder carcinoma a cross sectional study |
| topic | metabolic syndrome obesity urothelial carcinoma |
| url | https://journals.lww.com/10.4103/amsr.amsr_8_22 |
| work_keys_str_mv | AT soumyamondal metabolicsyndromeandbladdercarcinomaacrosssectionalstudy AT eeshanshkhare metabolicsyndromeandbladdercarcinomaacrosssectionalstudy AT dilipkumarpal metabolicsyndromeandbladdercarcinomaacrosssectionalstudy |