GABA Signaling in Spatial Memory changes in Animal Model of Alzheimer’s disease
Introduction: Alzheimer's disease is a progressive disease with mild memory loss that eventually leads to the loss of the ability to conduct conversation and react to the environment. Despite the proven role of the drugs used against the obvious causes of Alzheimer's disease, it still seem...
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Alborz University of Medical Sciences
2024-08-01
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| Series: | نشریه دانشگاه علوم پزشکی البرز |
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| Online Access: | http://aums.abzums.ac.ir/article-1-1804-en.pdf |
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| author | Bahareh Tavakoli-Far Marjan Hosseini Hadi Goudarzvand Samira Choopani Mahdi Goudarzvand |
| author_facet | Bahareh Tavakoli-Far Marjan Hosseini Hadi Goudarzvand Samira Choopani Mahdi Goudarzvand |
| author_sort | Bahareh Tavakoli-Far |
| collection | DOAJ |
| description | Introduction: Alzheimer's disease is a progressive disease with mild memory loss that eventually leads to the loss of the ability to conduct conversation and react to the environment. Despite the proven role of the drugs used against the obvious causes of Alzheimer's disease, it still seems impossible to achieve an effective and permanent treatment for the treatment of Alzheimer's disease. So, investigating different angles of GABAergic system signaling can be introduced as a promising target for the development of anti-Alzheimer drugs.
Materials and Methods: To induce Alzheimer's disease, the β-amyloid toxin at a dose of 5µg/µl was injected bilaterally into the hippocampus of Wistar male rats, and the rats were then treated with bilateral injection of GABA-A receptor agonist (muscimol) and antagonist (bicuculline), at a dose of 100 ng/µl/side in the hippocampus for 4 days. To assess the spatial memory of the animals, the parameters of the distance traveled by the animals, latency time to reach the hidden platform, and velocity of the animals were analyzed in Morris water maze test.
Findings: The distance traveled and the latency time to reach the hidden platform increased in the Morris water test following the injection of beta-amyloid, and the muscimol increased the amount of this memory impairment. The injection of bicuculline could not significantly change the spatial memory of the animals.
Conclusion: The results of this study indicate the destructive effect of beta-amyloid toxin on spatial memory, as well as the destructive role of muscimol in memory consolidation and retrieval. |
| format | Article |
| id | doaj-art-aeb1ca306a22459b87e456cc53cfb080 |
| institution | DOAJ |
| issn | 2322-3839 2588-3046 |
| language | fas |
| publishDate | 2024-08-01 |
| publisher | Alborz University of Medical Sciences |
| record_format | Article |
| series | نشریه دانشگاه علوم پزشکی البرز |
| spelling | doaj-art-aeb1ca306a22459b87e456cc53cfb0802025-08-20T02:49:52ZfasAlborz University of Medical Sciencesنشریه دانشگاه علوم پزشکی البرز2322-38392588-30462024-08-01133194203GABA Signaling in Spatial Memory changes in Animal Model of Alzheimer’s diseaseBahareh Tavakoli-Far0Marjan Hosseini1Hadi Goudarzvand2Samira Choopani3Mahdi Goudarzvand4 Associate Professor of Pharmacology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran Assistance Professor of Physiology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran Master of Essential Chemistry, National Standard Organization, of Iran, Karaj, Iran Master of Physiology, , Pasteur Institute, Tehran, Iran Associate Professor of Physiology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran Introduction: Alzheimer's disease is a progressive disease with mild memory loss that eventually leads to the loss of the ability to conduct conversation and react to the environment. Despite the proven role of the drugs used against the obvious causes of Alzheimer's disease, it still seems impossible to achieve an effective and permanent treatment for the treatment of Alzheimer's disease. So, investigating different angles of GABAergic system signaling can be introduced as a promising target for the development of anti-Alzheimer drugs. Materials and Methods: To induce Alzheimer's disease, the β-amyloid toxin at a dose of 5µg/µl was injected bilaterally into the hippocampus of Wistar male rats, and the rats were then treated with bilateral injection of GABA-A receptor agonist (muscimol) and antagonist (bicuculline), at a dose of 100 ng/µl/side in the hippocampus for 4 days. To assess the spatial memory of the animals, the parameters of the distance traveled by the animals, latency time to reach the hidden platform, and velocity of the animals were analyzed in Morris water maze test. Findings: The distance traveled and the latency time to reach the hidden platform increased in the Morris water test following the injection of beta-amyloid, and the muscimol increased the amount of this memory impairment. The injection of bicuculline could not significantly change the spatial memory of the animals. Conclusion: The results of this study indicate the destructive effect of beta-amyloid toxin on spatial memory, as well as the destructive role of muscimol in memory consolidation and retrieval.http://aums.abzums.ac.ir/article-1-1804-en.pdfalzheimer’s diseasegabaspatial memorybeta-amyloid |
| spellingShingle | Bahareh Tavakoli-Far Marjan Hosseini Hadi Goudarzvand Samira Choopani Mahdi Goudarzvand GABA Signaling in Spatial Memory changes in Animal Model of Alzheimer’s disease نشریه دانشگاه علوم پزشکی البرز alzheimer’s disease gaba spatial memory beta-amyloid |
| title | GABA Signaling in Spatial Memory changes in Animal Model of Alzheimer’s disease |
| title_full | GABA Signaling in Spatial Memory changes in Animal Model of Alzheimer’s disease |
| title_fullStr | GABA Signaling in Spatial Memory changes in Animal Model of Alzheimer’s disease |
| title_full_unstemmed | GABA Signaling in Spatial Memory changes in Animal Model of Alzheimer’s disease |
| title_short | GABA Signaling in Spatial Memory changes in Animal Model of Alzheimer’s disease |
| title_sort | gaba signaling in spatial memory changes in animal model of alzheimer s disease |
| topic | alzheimer’s disease gaba spatial memory beta-amyloid |
| url | http://aums.abzums.ac.ir/article-1-1804-en.pdf |
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