Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with Diabetes
Aim. To investigate the association between serum magnesium levels and microvascular complications among patients with diabetes. Methods. Patients with diabetes were recruited between April 2012 and January 2015. All patients received an assay of serum magnesium concentration, were screened for 24 h...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1260141 |
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| author | Jun Lu Yuying Gu Meixiang Guo Peihong Chen Hongtao Wang Xuemei Yu |
| author_facet | Jun Lu Yuying Gu Meixiang Guo Peihong Chen Hongtao Wang Xuemei Yu |
| author_sort | Jun Lu |
| collection | DOAJ |
| description | Aim. To investigate the association between serum magnesium levels and microvascular complications among patients with diabetes. Methods. Patients with diabetes were recruited between April 2012 and January 2015. All patients received an assay of serum magnesium concentration, were screened for 24 h albumin excretion rate, and underwent nonmydriatic fundus photography. Albuminuria and retinopathy were defined accordingly. A total of 3,100 patients with normal serum magnesium levels were included in this study. Results. Patients with albuminuria and/or retinopathy had lower levels of serum magnesium than patients without these complications (P<0.001). The prevalence of isolated albuminuria, isolated retinopathy, and combined albuminuria and retinopathy decreased as the concentration of serum magnesium increased. Multiple logistic regression analysis indicated that the odds ratio for isolated albuminuria, isolated retinopathy, and concomitant albuminuria and retinopathy decreased by approximately 20% for every 0.1 mmol/L increase in serum magnesium concentration. Conclusion. Serum magnesium levels were negatively associated with the risk of diabetic microvascular complications among patients with serum magnesium levels within the normal range. |
| format | Article |
| id | doaj-art-aeb0ceadf8e6460b9a78e93a73bf0196 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-aeb0ceadf8e6460b9a78e93a73bf01962025-08-20T02:19:06ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/12601411260141Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with DiabetesJun Lu0Yuying Gu1Meixiang Guo2Peihong Chen3Hongtao Wang4Xuemei Yu5Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, 6600 Nanfeng Road, Shanghai 201499, ChinaDepartment of Mathematics, Shanghai Business School, 2271 West Zhongshan Road, Shanghai 200235, ChinaDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, 6600 Nanfeng Road, Shanghai 201499, ChinaDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, 6600 Nanfeng Road, Shanghai 201499, ChinaDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, 6600 Nanfeng Road, Shanghai 201499, ChinaDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, 6600 Nanfeng Road, Shanghai 201499, ChinaAim. To investigate the association between serum magnesium levels and microvascular complications among patients with diabetes. Methods. Patients with diabetes were recruited between April 2012 and January 2015. All patients received an assay of serum magnesium concentration, were screened for 24 h albumin excretion rate, and underwent nonmydriatic fundus photography. Albuminuria and retinopathy were defined accordingly. A total of 3,100 patients with normal serum magnesium levels were included in this study. Results. Patients with albuminuria and/or retinopathy had lower levels of serum magnesium than patients without these complications (P<0.001). The prevalence of isolated albuminuria, isolated retinopathy, and combined albuminuria and retinopathy decreased as the concentration of serum magnesium increased. Multiple logistic regression analysis indicated that the odds ratio for isolated albuminuria, isolated retinopathy, and concomitant albuminuria and retinopathy decreased by approximately 20% for every 0.1 mmol/L increase in serum magnesium concentration. Conclusion. Serum magnesium levels were negatively associated with the risk of diabetic microvascular complications among patients with serum magnesium levels within the normal range.http://dx.doi.org/10.1155/2016/1260141 |
| spellingShingle | Jun Lu Yuying Gu Meixiang Guo Peihong Chen Hongtao Wang Xuemei Yu Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with Diabetes Journal of Diabetes Research |
| title | Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with Diabetes |
| title_full | Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with Diabetes |
| title_fullStr | Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with Diabetes |
| title_full_unstemmed | Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with Diabetes |
| title_short | Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with Diabetes |
| title_sort | serum magnesium concentration is inversely associated with albuminuria and retinopathy among patients with diabetes |
| url | http://dx.doi.org/10.1155/2016/1260141 |
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