Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases
The gut microbiota, a dynamic ecosystem of trillions of microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role of these metabolites, particularly short-chain fatty acids, indoles, and bile acids, in modulating immune...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/100 |
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| author | Eman K. E. Anwer Muhammad Ajagbe Moustafa Sherif Abobaker S. Musaibah Shuaib Mahmoud Ali ElBanbi Anwar Abdelnaser |
| author_facet | Eman K. E. Anwer Muhammad Ajagbe Moustafa Sherif Abobaker S. Musaibah Shuaib Mahmoud Ali ElBanbi Anwar Abdelnaser |
| author_sort | Eman K. E. Anwer |
| collection | DOAJ |
| description | The gut microbiota, a dynamic ecosystem of trillions of microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role of these metabolites, particularly short-chain fatty acids, indoles, and bile acids, in modulating immune responses, impacting epigenetic mechanisms, and contributing to disease processes. In gastrointestinal (GI) cancers such as colorectal, liver, and gastric cancer, microbial metabolites can drive tumorigenesis by promoting inflammation, DNA damage, and immune evasion. Conversely, these same metabolites hold therapeutic promise, potentially enhancing responses to chemotherapy and immunotherapy and even directly suppressing tumor growth. In addition, gut microbial metabolites play crucial roles in infectious disease susceptibility and resilience, mediating immune pathways that impact pathogen resistance. By consolidating recent insights into the gut microbiota’s role in shaping disease and health, this review underscores the therapeutic potential of targeting microbiome-derived metabolites for treating GI cancers and infectious diseases and calls for further research into microbiome-based interventions. |
| format | Article |
| id | doaj-art-aeaefc13d22843078e8da98024f61fd6 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-aeaefc13d22843078e8da98024f61fd62025-01-24T13:24:00ZengMDPI AGBiomedicines2227-90592025-01-0113110010.3390/biomedicines13010100Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious DiseasesEman K. E. Anwer0Muhammad Ajagbe1Moustafa Sherif2Abobaker S. Musaibah3Shuaib Mahmoud4Ali ElBanbi5Anwar Abdelnaser6Biotechnology Graduate Program, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, EgyptBiotechnology Graduate Program, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, EgyptBiotechnology Graduate Program, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, EgyptInstitute of Global Health and Human Ecology, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, EgyptInstitute of Global Health and Human Ecology, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, EgyptBiology Department, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, EgyptInstitute of Global Health and Human Ecology, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, EgyptThe gut microbiota, a dynamic ecosystem of trillions of microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role of these metabolites, particularly short-chain fatty acids, indoles, and bile acids, in modulating immune responses, impacting epigenetic mechanisms, and contributing to disease processes. In gastrointestinal (GI) cancers such as colorectal, liver, and gastric cancer, microbial metabolites can drive tumorigenesis by promoting inflammation, DNA damage, and immune evasion. Conversely, these same metabolites hold therapeutic promise, potentially enhancing responses to chemotherapy and immunotherapy and even directly suppressing tumor growth. In addition, gut microbial metabolites play crucial roles in infectious disease susceptibility and resilience, mediating immune pathways that impact pathogen resistance. By consolidating recent insights into the gut microbiota’s role in shaping disease and health, this review underscores the therapeutic potential of targeting microbiome-derived metabolites for treating GI cancers and infectious diseases and calls for further research into microbiome-based interventions.https://www.mdpi.com/2227-9059/13/1/100gut microbiomesecondary metabolitescancerinfectious diseasegastro-intestinal tracttumorigenesis |
| spellingShingle | Eman K. E. Anwer Muhammad Ajagbe Moustafa Sherif Abobaker S. Musaibah Shuaib Mahmoud Ali ElBanbi Anwar Abdelnaser Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases Biomedicines gut microbiome secondary metabolites cancer infectious disease gastro-intestinal tract tumorigenesis |
| title | Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases |
| title_full | Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases |
| title_fullStr | Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases |
| title_full_unstemmed | Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases |
| title_short | Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases |
| title_sort | gut microbiota secondary metabolites key roles in gi tract cancers and infectious diseases |
| topic | gut microbiome secondary metabolites cancer infectious disease gastro-intestinal tract tumorigenesis |
| url | https://www.mdpi.com/2227-9059/13/1/100 |
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