Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP)
Introduction COVID-19 pandemic has had a huge impact on global health to date, with 5.6 million cases in the UK since its emergence. The respiratory symptoms largely mimic those of pneumonia’ with symptoms ranging from mild to severe. The effects on respiratory physiology are not yet fully understoo...
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BMJ Publishing Group
2021-01-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/8/1/e001070.full |
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| author | James Stockley Brendan Cooper Eyas Alhuthail Andrew Coney |
| author_facet | James Stockley Brendan Cooper Eyas Alhuthail Andrew Coney |
| author_sort | James Stockley |
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| description | Introduction COVID-19 pandemic has had a huge impact on global health to date, with 5.6 million cases in the UK since its emergence. The respiratory symptoms largely mimic those of pneumonia’ with symptoms ranging from mild to severe. The effects on respiratory physiology are not yet fully understood, but evidence is emerging that there is much dysfunctional breathing reported but little information on tidal ventilation from the acute phase of the infection. Structured light plethysmography (SLP) is a contactless technique of respiratory function testing that measures tidal breathing parameters by assessing thoracoabdominal displacement.Methods In a postdischarge clinic, SLP was performed routinely on 110 hospitalised patients recovering from COVID-19 who had been screened for respiratory symptoms to confirm any respiratory changes occurring after the disease. Patients were categorised based on their hospital treatment in (1) the intensive therapy unit (ITU) (requiring intubation) (n=65) or (2) respiratory wards only (n=45). Data from these two patient cohorts were compared with preacquired data from healthy controls (n=30).Results We have found a significantly increased respiratory rate (p=0.006) in ITU patients compared with the healthy cohort and also a significant decrease in the inspiratory time (p=0.01), expiratory time (p=0.005) and the total breathing cycle (p=0.008). There were no significant differences between ITU and ward patients and no significant differences in healthy compared with ward patients. We examined the variability of breathing (‘entropy’) both in terms of the breath-to-breath interval and the volume-to-volume change. The breath-to-breath interval alone was significantly lower in ITU patients compared with healthy cohorts (p=0.02).Conclusion Our findings suggest that abnormalities in tidal breathing can be detected in COVID-19 recovery patients, and SLP may be a promising tool in assessing the aftermath of diseases such as COVID-19, particularly if more intensive management strategies such as mechanical ventilation are required. |
| format | Article |
| id | doaj-art-aeac0efc4d074febb2ce51263d5abfb2 |
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| issn | 2052-4439 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open Respiratory Research |
| spelling | doaj-art-aeac0efc4d074febb2ce51263d5abfb22025-08-20T02:22:28ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392021-01-018110.1136/bmjresp-2021-001070Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP)James Stockley0Brendan Cooper1Eyas Alhuthail2Andrew Coney36 Lung Function & Sleep (QEHB Site), University Hospital Birmingham, Birmingham, UKLung Function & Sleep, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UKSchool of Biomedical Sciences, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK1University of Birmingham, Institute of Clinical Sciences, University of Birmingham, Birmingham, WMD B15 2TT, UKIntroduction COVID-19 pandemic has had a huge impact on global health to date, with 5.6 million cases in the UK since its emergence. The respiratory symptoms largely mimic those of pneumonia’ with symptoms ranging from mild to severe. The effects on respiratory physiology are not yet fully understood, but evidence is emerging that there is much dysfunctional breathing reported but little information on tidal ventilation from the acute phase of the infection. Structured light plethysmography (SLP) is a contactless technique of respiratory function testing that measures tidal breathing parameters by assessing thoracoabdominal displacement.Methods In a postdischarge clinic, SLP was performed routinely on 110 hospitalised patients recovering from COVID-19 who had been screened for respiratory symptoms to confirm any respiratory changes occurring after the disease. Patients were categorised based on their hospital treatment in (1) the intensive therapy unit (ITU) (requiring intubation) (n=65) or (2) respiratory wards only (n=45). Data from these two patient cohorts were compared with preacquired data from healthy controls (n=30).Results We have found a significantly increased respiratory rate (p=0.006) in ITU patients compared with the healthy cohort and also a significant decrease in the inspiratory time (p=0.01), expiratory time (p=0.005) and the total breathing cycle (p=0.008). There were no significant differences between ITU and ward patients and no significant differences in healthy compared with ward patients. We examined the variability of breathing (‘entropy’) both in terms of the breath-to-breath interval and the volume-to-volume change. The breath-to-breath interval alone was significantly lower in ITU patients compared with healthy cohorts (p=0.02).Conclusion Our findings suggest that abnormalities in tidal breathing can be detected in COVID-19 recovery patients, and SLP may be a promising tool in assessing the aftermath of diseases such as COVID-19, particularly if more intensive management strategies such as mechanical ventilation are required.https://bmjopenrespres.bmj.com/content/8/1/e001070.full |
| spellingShingle | James Stockley Brendan Cooper Eyas Alhuthail Andrew Coney Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP) BMJ Open Respiratory Research |
| title | Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP) |
| title_full | Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP) |
| title_fullStr | Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP) |
| title_full_unstemmed | Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP) |
| title_short | Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP) |
| title_sort | measurement of breathing in patients with post covid 19 using structured light plethysmography slp |
| url | https://bmjopenrespres.bmj.com/content/8/1/e001070.full |
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