Promoting ferroptosis of keloid fibroblasts: a key mechanism underlying the efficacy of 5-aminolevulinic acid photodynamic therapy for keloids

Promoting ferroptosis of keloid fibroblasts: a key mechanism underlying the efficacy of 5-aminolevulinic acid photodynamic therapy for keloids

Objective: This study aims to evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for keloid treatment and explore its molecular mechanisms. Methods: Nine keloid patients were enrolled between May 2024 and March 2025. All patients received ALA-PDT, with therapeutic efficacy...

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Bibliographic Details
Main Authors: Jiaying Zhang, Yahui Feng, Ning Zhang, Xiaoqing Wang, Dongmei Li, Dongmei Shi
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Photodiagnosis and Photodynamic Therapy
Subjects:
Keloid
5-aminolevulinic acid photodynamic therapy (ALA-PDT)
Ferroptosis
Collagen remodeling
Reactive oxygen species (ROS)
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S1572100025002686
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