Dynamics of pro and anti-inflammatory cytokines in the early period of dental implantation. Part I
Dynamics and proportions of proinflammatory and anti-inflammatory cytokines in patients with dental implantation were studied. In 106 patients with dental implants without complications, the study was performed before and after 7-10, 30 days. IL-1β, IL-6, TNF-α, IFN-γ, IL-4, IL-10 were determined in...
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| Format: | Article |
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| Language: | Russian |
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LLC "Endo Press"
2020-03-01
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| Series: | Эндодонтия Today |
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| Online Access: | https://www.endodont.ru/jour/article/view/80 |
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| description | Dynamics and proportions of proinflammatory and anti-inflammatory cytokines in patients with dental implantation were studied. In 106 patients with dental implants without complications, the study was performed before and after 7-10, 30 days. IL-1β, IL-6, TNF-α, IFN-γ, IL-4, IL-10 were determined in the gingival fluid by solid-phase enzyme immunoassay. A significant increase in the level of TNF-α and IL-10 was observed on day 7-10, and TNF-α at day 30. At 7-10 days after implantation, an imbalance in the ratio of IL-1β / IL-10, TNF-α / IL-4, TNF-α / IL-10 was observed in comparison with the control, the proportion of pro- and anti-inflammatory cytokines was almost normalized on day 30, Only the ratio of TNF-α / IL-10 remained elevated. The enhanced synthesis of pro-inflammatory cytokines was countered by the enhanced synthesis of IL-10, which in our opinion is related to the ability of IL-10 to inhibit the cytotoxic activity that TNF-α exerts. |
| format | Article |
| id | doaj-art-aea8b58046444c87b588d5df23016b7d |
| institution | Kabale University |
| issn | 1683-2981 1726-7242 |
| language | Russian |
| publishDate | 2020-03-01 |
| publisher | LLC "Endo Press" |
| record_format | Article |
| series | Эндодонтия Today |
| spelling | doaj-art-aea8b58046444c87b588d5df23016b7d2025-08-20T03:35:01ZrusLLC "Endo Press"Эндодонтия Today1683-29811726-72422020-03-01153262880Dynamics of pro and anti-inflammatory cytokines in the early period of dental implantation. Part I012Азербайджанский медицинский университетАзербайджанский медицинский университетАзербайджанский медицинский университетDynamics and proportions of proinflammatory and anti-inflammatory cytokines in patients with dental implantation were studied. In 106 patients with dental implants without complications, the study was performed before and after 7-10, 30 days. IL-1β, IL-6, TNF-α, IFN-γ, IL-4, IL-10 were determined in the gingival fluid by solid-phase enzyme immunoassay. A significant increase in the level of TNF-α and IL-10 was observed on day 7-10, and TNF-α at day 30. At 7-10 days after implantation, an imbalance in the ratio of IL-1β / IL-10, TNF-α / IL-4, TNF-α / IL-10 was observed in comparison with the control, the proportion of pro- and anti-inflammatory cytokines was almost normalized on day 30, Only the ratio of TNF-α / IL-10 remained elevated. The enhanced synthesis of pro-inflammatory cytokines was countered by the enhanced synthesis of IL-10, which in our opinion is related to the ability of IL-10 to inhibit the cytotoxic activity that TNF-α exerts.https://www.endodont.ru/jour/article/view/80дентальная имплантациязубодесневая жидкостьцитокиныдинамикакоэффициент соотношенияdental implantationdentogingival fluidcytokinesdynamicscorrelation coefficient |
| spellingShingle | Dynamics of pro and anti-inflammatory cytokines in the early period of dental implantation. Part I Эндодонтия Today дентальная имплантация зубодесневая жидкость цитокины динамика коэффициент соотношения dental implantation dentogingival fluid cytokines dynamics correlation coefficient |
| title | Dynamics of pro and anti-inflammatory cytokines in the early period of dental implantation. Part I |
| title_full | Dynamics of pro and anti-inflammatory cytokines in the early period of dental implantation. Part I |
| title_fullStr | Dynamics of pro and anti-inflammatory cytokines in the early period of dental implantation. Part I |
| title_full_unstemmed | Dynamics of pro and anti-inflammatory cytokines in the early period of dental implantation. Part I |
| title_short | Dynamics of pro and anti-inflammatory cytokines in the early period of dental implantation. Part I |
| title_sort | dynamics of pro and anti inflammatory cytokines in the early period of dental implantation part i |
| topic | дентальная имплантация зубодесневая жидкость цитокины динамика коэффициент соотношения dental implantation dentogingival fluid cytokines dynamics correlation coefficient |
| url | https://www.endodont.ru/jour/article/view/80 |