Violations of robustness trade‐offs
Abstract Biological robustness is a principle that may shed light on system‐level characteristics of biological systems. One intriguing aspect of the concept of biological robustness is the possible existence of intrinsic trade‐offs among robustness, fragility, performance, and so on. At the same ti...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2010-06-01
|
| Series: | Molecular Systems Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/msb.2010.40 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850179738844266496 |
|---|---|
| author | Hiroaki Kitano |
| author_facet | Hiroaki Kitano |
| author_sort | Hiroaki Kitano |
| collection | DOAJ |
| description | Abstract Biological robustness is a principle that may shed light on system‐level characteristics of biological systems. One intriguing aspect of the concept of biological robustness is the possible existence of intrinsic trade‐offs among robustness, fragility, performance, and so on. At the same time, whether such trade‐offs hold regardless of the situation or hold only under specific conditions warrants careful investigation. In this paper, we reassess this concept and argue that biological robustness may hold only when a system is sufficiently optimized and that it may not be conserved when there is room for optimization in its design. Several testable predictions and implications for cell culture experiments are presented. |
| format | Article |
| id | doaj-art-aea03fe497204bfaa6be66f70e6706e3 |
| institution | OA Journals |
| issn | 1744-4292 |
| language | English |
| publishDate | 2010-06-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-aea03fe497204bfaa6be66f70e6706e32025-08-20T02:18:25ZengSpringer NatureMolecular Systems Biology1744-42922010-06-01611810.1038/msb.2010.40Violations of robustness trade‐offsHiroaki Kitano0The Systems Biology InstituteAbstract Biological robustness is a principle that may shed light on system‐level characteristics of biological systems. One intriguing aspect of the concept of biological robustness is the possible existence of intrinsic trade‐offs among robustness, fragility, performance, and so on. At the same time, whether such trade‐offs hold regardless of the situation or hold only under specific conditions warrants careful investigation. In this paper, we reassess this concept and argue that biological robustness may hold only when a system is sufficiently optimized and that it may not be conserved when there is room for optimization in its design. Several testable predictions and implications for cell culture experiments are presented.https://doi.org/10.1038/msb.2010.40evolutionportfolio selectionrobustnesssuboptimalitytrade‐offs |
| spellingShingle | Hiroaki Kitano Violations of robustness trade‐offs Molecular Systems Biology evolution portfolio selection robustness suboptimality trade‐offs |
| title | Violations of robustness trade‐offs |
| title_full | Violations of robustness trade‐offs |
| title_fullStr | Violations of robustness trade‐offs |
| title_full_unstemmed | Violations of robustness trade‐offs |
| title_short | Violations of robustness trade‐offs |
| title_sort | violations of robustness trade offs |
| topic | evolution portfolio selection robustness suboptimality trade‐offs |
| url | https://doi.org/10.1038/msb.2010.40 |
| work_keys_str_mv | AT hiroakikitano violationsofrobustnesstradeoffs |