Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrode
One of the significant durability challenges is the corrosion of reinforced concrete. A gold nanoparticle/reduced graphene oxide modified glassy carbon electrode (AuNPs-rGO-GCE) was fabricated using an electrochemical reduction method for the simultaneous determination of paracetamol (PAR) and chlo...
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| Format: | Article |
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International Association of Physical Chemists (IAPC)
2025-08-01
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| Series: | Journal of Electrochemical Science and Engineering |
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| Online Access: | https://pub.iapchem.org/ojs/index.php/JESE/article/view/2841 |
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| author | Huynh Van Chung Nguyen Hai Phong Dao Thi Cam Minh Ho Xuan Anh Vu Pham Khac Lieu Nguyen Thi Thanh Huyen Trinh Ngoc Dat Doan Manh Dung Do Thi Duyen Dinh Quang Khieu |
| author_facet | Huynh Van Chung Nguyen Hai Phong Dao Thi Cam Minh Ho Xuan Anh Vu Pham Khac Lieu Nguyen Thi Thanh Huyen Trinh Ngoc Dat Doan Manh Dung Do Thi Duyen Dinh Quang Khieu |
| author_sort | Huynh Van Chung |
| collection | DOAJ |
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One of the significant durability challenges is the corrosion of reinforced concrete. A gold nanoparticle/reduced graphene oxide modified glassy carbon electrode (AuNPs-rGO-GCE) was fabricated using an electrochemical reduction method for the simultaneous determination of paracetamol (PAR) and chlorpheniramine maleate (CPM). AuNPs-rGO modified GC electrodes were prepared through direct electrochemical reduction of GO to rGO, followed by direct reduction of Au ions to Au on the rGO matrix. X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectra, Raman spectroscopy, energy dispersive X-ray spectroscopy, high-resolution transmission electron microscopy, electrochemical impedance spectroscopy, and X-ray photoelectron spectroscopy characterized the resulting AuNPs-rGO. It was found that AuNPs around 15.4 nm were highly dispersed on the rGO. The modification of GCE by AuNPs-rGO accelerates the electron transfer process and increases the conductivity of the electrode. The AuNPs-rGO modified electrode was used to simultaneously determine PAR and CPM using the square-wave anodic stripping voltammetry (SQW-ASV) method. Under suitable experimental conditions, the SQW-ASV method using AuNPs-rGO-GCE showed a wide linear range from 23.7 µM to 140 µM for PAR and from 7.5 µM to 54 µM for CPM. The limit of detection of PAR and CPM was 7.12 µM and 2.54 µM, respectively. The proposed SQW-ASV method was applied to analyze PAR and CPM in samples of herbal medicine simultaneously, and the results were compared with those of high-performance liquid chromatography, with no statistical difference.
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| format | Article |
| id | doaj-art-ae9e5489da8e4b879b37b78d15d81bc6 |
| institution | Kabale University |
| issn | 1847-9286 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | Journal of Electrochemical Science and Engineering |
| spelling | doaj-art-ae9e5489da8e4b879b37b78d15d81bc62025-08-25T19:46:00ZengInternational Association of Physical Chemists (IAPC)Journal of Electrochemical Science and Engineering1847-92862025-08-0110.5599/jese.2841Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrodeHuynh Van Chung0https://orcid.org/0000-0001-7519-1196Nguyen Hai Phong1https://orcid.org/0000-0001-5354-1052Dao Thi Cam Minh2https://orcid.org/0000-0003-0786-3178Ho Xuan Anh Vu3https://orcid.org/0000-0001-7685-2320Pham Khac Lieu4https://orcid.org/0000-0002-9002-1416Nguyen Thi Thanh Huyen5https://orcid.org/0009-0006-8534-0662Trinh Ngoc Dat6https://orcid.org/0009-0009-9941-2630Doan Manh Dung7https://orcid.org/0000-0002-1229-7839Do Thi Duyen8https://orcid.org/0009-0004-3265-5084Dinh Quang Khieu9https://orcid.org/0000-0003-3473-6377University of Sciences, Hue University, Hue City, Vietnam and Faculty of Pharmacy, Buon Ma Thuot Medical University, Buon Ma Thuot City, VietnamUniversity of Sciences, Hue University, Hue City, VietnamUniversity of Medicine and Pharmacy, Hue University, Hue City, VietnamUniversity of Sciences, Hue University, Hue City, VietnamUniversity of Sciences, Hue University, Hue City, VietnamInstitute of Research and Development, Duy Tan University, Danang City, VietnamUniversity of Education and Science, The University of Danang, Danang City, VietnamInstitute of Biotechnology and Environment, Tay Nguyen University, Buon Ma Thuot, VietnamInstitute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi city, VietnamUniversity of Sciences, Hue University, Hue City, Vietnam One of the significant durability challenges is the corrosion of reinforced concrete. A gold nanoparticle/reduced graphene oxide modified glassy carbon electrode (AuNPs-rGO-GCE) was fabricated using an electrochemical reduction method for the simultaneous determination of paracetamol (PAR) and chlorpheniramine maleate (CPM). AuNPs-rGO modified GC electrodes were prepared through direct electrochemical reduction of GO to rGO, followed by direct reduction of Au ions to Au on the rGO matrix. X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectra, Raman spectroscopy, energy dispersive X-ray spectroscopy, high-resolution transmission electron microscopy, electrochemical impedance spectroscopy, and X-ray photoelectron spectroscopy characterized the resulting AuNPs-rGO. It was found that AuNPs around 15.4 nm were highly dispersed on the rGO. The modification of GCE by AuNPs-rGO accelerates the electron transfer process and increases the conductivity of the electrode. The AuNPs-rGO modified electrode was used to simultaneously determine PAR and CPM using the square-wave anodic stripping voltammetry (SQW-ASV) method. Under suitable experimental conditions, the SQW-ASV method using AuNPs-rGO-GCE showed a wide linear range from 23.7 µM to 140 µM for PAR and from 7.5 µM to 54 µM for CPM. The limit of detection of PAR and CPM was 7.12 µM and 2.54 µM, respectively. The proposed SQW-ASV method was applied to analyze PAR and CPM in samples of herbal medicine simultaneously, and the results were compared with those of high-performance liquid chromatography, with no statistical difference. https://pub.iapchem.org/ojs/index.php/JESE/article/view/2841Drug sensorssquare-wave anodic stripping voltammetryochemically reduced graphene oxideherbal medicine |
| spellingShingle | Huynh Van Chung Nguyen Hai Phong Dao Thi Cam Minh Ho Xuan Anh Vu Pham Khac Lieu Nguyen Thi Thanh Huyen Trinh Ngoc Dat Doan Manh Dung Do Thi Duyen Dinh Quang Khieu Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrode Journal of Electrochemical Science and Engineering Drug sensors square-wave anodic stripping voltammetry ochemically reduced graphene oxide herbal medicine |
| title | Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrode |
| title_full | Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrode |
| title_fullStr | Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrode |
| title_full_unstemmed | Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrode |
| title_short | Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrode |
| title_sort | electrochemical determination of paracetamol and chlorpheniramine using aunps rgo modified glassy carbon electrode |
| topic | Drug sensors square-wave anodic stripping voltammetry ochemically reduced graphene oxide herbal medicine |
| url | https://pub.iapchem.org/ojs/index.php/JESE/article/view/2841 |
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