Insights into the detection of AMPA cross-reactivity: comparing cyclic peptide- to protein-based assays

Insights into the detection of AMPA cross-reactivity: comparing cyclic peptide- to protein-based assays

Abstract Background Autoantibodies targeting antigens carrying distinct post-translational modifications (PTMs), including citrullinated, carbamylated, and acetylated residues, are characteristic for rheumatoid arthritis (RA). These anti-modified protein antibodies (AMPAs) are typically detected usi...

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Main Authors: Roxane Biersteker, Aegli Athanasiadou, Stef van der Meulen, Tineke J. van Wesemael, Linda M. Slot, Theresa Kissel, René E. M. Toes, Leendert A. Trouw, Diane van der Woude
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Arthritis Research & Therapy
Subjects:
Anti-modified protein antibodies
ACPA
Autoantibodies
Cross-reactivity
Rheumatoid arthritis
Antigen backbone
Online Access:https://doi.org/10.1186/s13075-025-03591-y
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