Bioactive Calcium Silico-Phosphate Glasses Doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>: Biocompatibility, Bioactivity and Antibacterial Activity
Bioactive glasses in the SiO<sub>2</sub>-CaO-P<sub>2</sub>O<sub>5</sub> system represent emerging materials for hard-tissue-regeneration applications. This article focuses on the synthesis, characterization, and biological interaction of glasses doped with Mg<s...
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MDPI AG
2025-05-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/6/534 |
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| author | Laura-Nicoleta Dragomir Cristina-Daniela Ghiţulică Andreia Cucuruz Andreea Lazar Georgeta Voicu Sorina Dinescu |
| author_facet | Laura-Nicoleta Dragomir Cristina-Daniela Ghiţulică Andreia Cucuruz Andreea Lazar Georgeta Voicu Sorina Dinescu |
| author_sort | Laura-Nicoleta Dragomir |
| collection | DOAJ |
| description | Bioactive glasses in the SiO<sub>2</sub>-CaO-P<sub>2</sub>O<sub>5</sub> system represent emerging materials for hard-tissue-regeneration applications. This article focuses on the synthesis, characterization, and biological interaction of glasses doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>, with an emphasis on their effects on biomineralization, antibacterial behavior, and interactions with preosteoblasts from the MC3T3-E1 cell line. The bioglasses were synthesized using the sol-gel method, and the vitreous nature remained predominant even after thermal treatment at 600 °C for 2 h. From an in vitro perspective, the synthesized bioglasses demonstrated strong cell adhesion and proliferation (notably in the case of Mg<sup>2+</sup> doping), low cytotoxicity, and antibacterial properties (especially in Zn<sup>2+</sup>-doped samples). Additionally, the simultaneous doping with Mg<sup>2+</sup> and Zn<sup>2+</sup> of the bioactive glass matrix is a prospective strategy for developing biomaterials with a “dual” biological characteristics–both osteoinductive and antibacterial. |
| format | Article |
| id | doaj-art-ae9da0dd45774c5185bd9d100b401cb3 |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-ae9da0dd45774c5185bd9d100b401cb32025-08-20T02:24:17ZengMDPI AGAntibiotics2079-63822025-05-0114653410.3390/antibiotics14060534Bioactive Calcium Silico-Phosphate Glasses Doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>: Biocompatibility, Bioactivity and Antibacterial ActivityLaura-Nicoleta Dragomir0Cristina-Daniela Ghiţulică1Andreia Cucuruz2Andreea Lazar3Georgeta Voicu4Sorina Dinescu5Science and Engineering of Oxide Materials and Nanomaterials Department, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu Street, Sector 1, RO-011061 Bucharest, RomaniaScience and Engineering of Oxide Materials and Nanomaterials Department, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu Street, Sector 1, RO-011061 Bucharest, RomaniaBiomaterials and Medical Devices Department, Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu Street, Sector 1, RO-011061 Bucharest, RomaniaBiochemistry and Molecular Biology Department, Faculty of Biology, University of Bucharest, Splaiul Independenței, RO-050095 Bucharest, RomaniaScience and Engineering of Oxide Materials and Nanomaterials Department, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu Street, Sector 1, RO-011061 Bucharest, RomaniaBiochemistry and Molecular Biology Department, Faculty of Biology, University of Bucharest, Splaiul Independenței, RO-050095 Bucharest, RomaniaBioactive glasses in the SiO<sub>2</sub>-CaO-P<sub>2</sub>O<sub>5</sub> system represent emerging materials for hard-tissue-regeneration applications. This article focuses on the synthesis, characterization, and biological interaction of glasses doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>, with an emphasis on their effects on biomineralization, antibacterial behavior, and interactions with preosteoblasts from the MC3T3-E1 cell line. The bioglasses were synthesized using the sol-gel method, and the vitreous nature remained predominant even after thermal treatment at 600 °C for 2 h. From an in vitro perspective, the synthesized bioglasses demonstrated strong cell adhesion and proliferation (notably in the case of Mg<sup>2+</sup> doping), low cytotoxicity, and antibacterial properties (especially in Zn<sup>2+</sup>-doped samples). Additionally, the simultaneous doping with Mg<sup>2+</sup> and Zn<sup>2+</sup> of the bioactive glass matrix is a prospective strategy for developing biomaterials with a “dual” biological characteristics–both osteoinductive and antibacterial.https://www.mdpi.com/2079-6382/14/6/534bioactive glassbiomineralizationantibacterial activity |
| spellingShingle | Laura-Nicoleta Dragomir Cristina-Daniela Ghiţulică Andreia Cucuruz Andreea Lazar Georgeta Voicu Sorina Dinescu Bioactive Calcium Silico-Phosphate Glasses Doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>: Biocompatibility, Bioactivity and Antibacterial Activity Antibiotics bioactive glass biomineralization antibacterial activity |
| title | Bioactive Calcium Silico-Phosphate Glasses Doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>: Biocompatibility, Bioactivity and Antibacterial Activity |
| title_full | Bioactive Calcium Silico-Phosphate Glasses Doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>: Biocompatibility, Bioactivity and Antibacterial Activity |
| title_fullStr | Bioactive Calcium Silico-Phosphate Glasses Doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>: Biocompatibility, Bioactivity and Antibacterial Activity |
| title_full_unstemmed | Bioactive Calcium Silico-Phosphate Glasses Doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>: Biocompatibility, Bioactivity and Antibacterial Activity |
| title_short | Bioactive Calcium Silico-Phosphate Glasses Doped with Mg<sup>2+</sup> and/or Zn<sup>2+</sup>: Biocompatibility, Bioactivity and Antibacterial Activity |
| title_sort | bioactive calcium silico phosphate glasses doped with mg sup 2 sup and or zn sup 2 sup biocompatibility bioactivity and antibacterial activity |
| topic | bioactive glass biomineralization antibacterial activity |
| url | https://www.mdpi.com/2079-6382/14/6/534 |
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