Effect of phosphodiesterase inhibitors in the bladder
Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, K-channel modulated pathways, and the l-cystei...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Asian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388215000387 |
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| _version_ | 1850243807742787584 |
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| author | Bilal Chughtai Aizaz Ali Claire Dunphy Steven A. Kaplan |
| author_facet | Bilal Chughtai Aizaz Ali Claire Dunphy Steven A. Kaplan |
| author_sort | Bilal Chughtai |
| collection | DOAJ |
| description | Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, K-channel modulated pathways, and the l-cysteine/H2S pathway. PDE5 inhibitors exert their effect in muscle cells, nerve fibers, and interstitial cells (ICs). The use of PDE5 inhibitors led to improvement in LUTS. This included urodynamic parameters. PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate. |
| format | Article |
| id | doaj-art-ae9bb15c5fe640eab6ad84fb0e8a99c0 |
| institution | OA Journals |
| issn | 2214-3882 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-ae9bb15c5fe640eab6ad84fb0e8a99c02025-08-20T01:59:53ZengElsevierAsian Journal of Urology2214-38822015-01-0121333710.1016/j.ajur.2015.04.014Effect of phosphodiesterase inhibitors in the bladderBilal ChughtaiAizaz AliClaire DunphySteven A. KaplanMany aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, K-channel modulated pathways, and the l-cysteine/H2S pathway. PDE5 inhibitors exert their effect in muscle cells, nerve fibers, and interstitial cells (ICs). The use of PDE5 inhibitors led to improvement in LUTS. This included urodynamic parameters. PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate.http://www.sciencedirect.com/science/article/pii/S2214388215000387Lower urinary tract symptoms (LUTS)Overactive bladder syndrome (OAB)Phosphodiesterase type 5 inhibitorsNO/cGMPcAMP |
| spellingShingle | Bilal Chughtai Aizaz Ali Claire Dunphy Steven A. Kaplan Effect of phosphodiesterase inhibitors in the bladder Asian Journal of Urology Lower urinary tract symptoms (LUTS) Overactive bladder syndrome (OAB) Phosphodiesterase type 5 inhibitors NO/cGMP cAMP |
| title | Effect of phosphodiesterase inhibitors in the bladder |
| title_full | Effect of phosphodiesterase inhibitors in the bladder |
| title_fullStr | Effect of phosphodiesterase inhibitors in the bladder |
| title_full_unstemmed | Effect of phosphodiesterase inhibitors in the bladder |
| title_short | Effect of phosphodiesterase inhibitors in the bladder |
| title_sort | effect of phosphodiesterase inhibitors in the bladder |
| topic | Lower urinary tract symptoms (LUTS) Overactive bladder syndrome (OAB) Phosphodiesterase type 5 inhibitors NO/cGMP cAMP |
| url | http://www.sciencedirect.com/science/article/pii/S2214388215000387 |
| work_keys_str_mv | AT bilalchughtai effectofphosphodiesteraseinhibitorsinthebladder AT aizazali effectofphosphodiesteraseinhibitorsinthebladder AT clairedunphy effectofphosphodiesteraseinhibitorsinthebladder AT stevenakaplan effectofphosphodiesteraseinhibitorsinthebladder |