KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India
Objective: This study aims at detecting KIBRA promoter methylation and association with clinic-pathological manifestations in renal cancer. Materials and Methods: In this study, we have studied the KIBRA promoter methylation in twenty cases of renal cell cancer and compared them to their stage, gra...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-09-01
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| Series: | Annals of Medical Science and Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/amsr.amsr_32_23 |
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| author | Avisek Dutta Biswabandhu Bankura Madhusudan Das Dilip Kumar Pal |
| author_facet | Avisek Dutta Biswabandhu Bankura Madhusudan Das Dilip Kumar Pal |
| author_sort | Avisek Dutta |
| collection | DOAJ |
| description | Objective:
This study aims at detecting KIBRA promoter methylation and association with clinic-pathological manifestations in renal cancer.
Materials and Methods:
In this study, we have studied the KIBRA promoter methylation in twenty cases of renal cell cancer and compared them to their stage, grade, and histopathology.
Result:
We have found that significant amount of KIBRA promoter methylation is present in high grade tumors irrespective of the stage. 5 out of 6 grade III tumors and all 6 grade IV tumors were positive for significant KIBRA promoter methylation as compared to 1 out of 5 grade I tumor.
Conclusion:
DNA methylation alterations participate in renal carcinogenesis which significantly correlated with the clinicopathological diversity of clear cell renal cell carcinomas and can be considered as potential targets for therapy. |
| format | Article |
| id | doaj-art-ae9bb04ce8d24e49b37ffff949f5b5a6 |
| institution | DOAJ |
| issn | 2949-785X |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Medical Science and Research |
| spelling | doaj-art-ae9bb04ce8d24e49b37ffff949f5b5a62025-08-20T02:55:03ZengWolters Kluwer Medknow PublicationsAnnals of Medical Science and Research2949-785X2023-09-012315615910.4103/amsr.amsr_32_23KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern IndiaAvisek DuttaBiswabandhu BankuraMadhusudan DasDilip Kumar PalObjective: This study aims at detecting KIBRA promoter methylation and association with clinic-pathological manifestations in renal cancer. Materials and Methods: In this study, we have studied the KIBRA promoter methylation in twenty cases of renal cell cancer and compared them to their stage, grade, and histopathology. Result: We have found that significant amount of KIBRA promoter methylation is present in high grade tumors irrespective of the stage. 5 out of 6 grade III tumors and all 6 grade IV tumors were positive for significant KIBRA promoter methylation as compared to 1 out of 5 grade I tumor. Conclusion: DNA methylation alterations participate in renal carcinogenesis which significantly correlated with the clinicopathological diversity of clear cell renal cell carcinomas and can be considered as potential targets for therapy.https://journals.lww.com/10.4103/amsr.amsr_32_23clear cell cancerdna methylationkibra promoterrenal cell cancer |
| spellingShingle | Avisek Dutta Biswabandhu Bankura Madhusudan Das Dilip Kumar Pal KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India Annals of Medical Science and Research clear cell cancer dna methylation kibra promoter renal cell cancer |
| title | KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India |
| title_full | KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India |
| title_fullStr | KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India |
| title_full_unstemmed | KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India |
| title_short | KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India |
| title_sort | kibra promoter methylation and association with clinical manifestation of renal cancer a study in a tertiary institute in eastern india |
| topic | clear cell cancer dna methylation kibra promoter renal cell cancer |
| url | https://journals.lww.com/10.4103/amsr.amsr_32_23 |
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