KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India
Objective: This study aims at detecting KIBRA promoter methylation and association with clinic-pathological manifestations in renal cancer. Materials and Methods: In this study, we have studied the KIBRA promoter methylation in twenty cases of renal cell cancer and compared them to their stage, gra...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-09-01
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| Series: | Annals of Medical Science and Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/amsr.amsr_32_23 |
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| Summary: | Objective:
This study aims at detecting KIBRA promoter methylation and association with clinic-pathological manifestations in renal cancer.
Materials and Methods:
In this study, we have studied the KIBRA promoter methylation in twenty cases of renal cell cancer and compared them to their stage, grade, and histopathology.
Result:
We have found that significant amount of KIBRA promoter methylation is present in high grade tumors irrespective of the stage. 5 out of 6 grade III tumors and all 6 grade IV tumors were positive for significant KIBRA promoter methylation as compared to 1 out of 5 grade I tumor.
Conclusion:
DNA methylation alterations participate in renal carcinogenesis which significantly correlated with the clinicopathological diversity of clear cell renal cell carcinomas and can be considered as potential targets for therapy. |
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| ISSN: | 2949-785X |