Genetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid Adenoma
Genomic aberrations associated with atypical parathyroid adenoma (AA) are poorly understood. Thus, herein, we sought to expand our current understanding of the molecular basis of atypical parathyroid adenomas. We analyzed 134 samples that had been surgically obtained from parathyroid tumors, includi...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2021/6666257 |
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| _version_ | 1850160516436066304 |
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| author | Xinxin Mao Yan Wu Shuangni Yu Jie Chen |
| author_facet | Xinxin Mao Yan Wu Shuangni Yu Jie Chen |
| author_sort | Xinxin Mao |
| collection | DOAJ |
| description | Genomic aberrations associated with atypical parathyroid adenoma (AA) are poorly understood. Thus, herein, we sought to expand our current understanding of the molecular basis of atypical parathyroid adenomas. We analyzed 134 samples that had been surgically obtained from parathyroid tumors, including parathyroid carcinomas, atypical parathyroid adenomas, and parathyroid adenomas. The tumors were harvested from formalin-fixed, paraffin-embedded tissues. Fifteen tumor-related genes from recently published genome sequencing data were subjected to targeted sequencing analysis, and an average sequencing depth of 500x was achieved. Sixteen (16/50, 32%) AA tumors harbored at least one of the following genomic alterations: CDC73 (12, 24%), EZH2 (4, 8%), HIC1 (1, 2%), and CDKN2A (1, 2%). Our study identified, for the first time, a relatively high frequency of genomic alterations in patients with AA in a Chinese population. This suggests that AA arises de novo, rather than developing from a parathyroid adenoma. Altogether, these findings will improve our understanding of the malignant potential of parathyroid tumors at the molecular level. |
| format | Article |
| id | doaj-art-ae991ca9fed34dcd9a8a57e38b503c3d |
| institution | OA Journals |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-ae991ca9fed34dcd9a8a57e38b503c3d2025-08-20T02:23:08ZengWileyInternational Journal of Genomics2314-436X2314-43782021-01-01202110.1155/2021/66662576666257Genetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid AdenomaXinxin Mao0Yan Wu1Shuangni Yu2Jie Chen3Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuai Fu Yuan Hu Tong, Beijing 100730, ChinaDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuai Fu Yuan Hu Tong, Beijing 100730, ChinaDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuai Fu Yuan Hu Tong, Beijing 100730, ChinaDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuai Fu Yuan Hu Tong, Beijing 100730, ChinaGenomic aberrations associated with atypical parathyroid adenoma (AA) are poorly understood. Thus, herein, we sought to expand our current understanding of the molecular basis of atypical parathyroid adenomas. We analyzed 134 samples that had been surgically obtained from parathyroid tumors, including parathyroid carcinomas, atypical parathyroid adenomas, and parathyroid adenomas. The tumors were harvested from formalin-fixed, paraffin-embedded tissues. Fifteen tumor-related genes from recently published genome sequencing data were subjected to targeted sequencing analysis, and an average sequencing depth of 500x was achieved. Sixteen (16/50, 32%) AA tumors harbored at least one of the following genomic alterations: CDC73 (12, 24%), EZH2 (4, 8%), HIC1 (1, 2%), and CDKN2A (1, 2%). Our study identified, for the first time, a relatively high frequency of genomic alterations in patients with AA in a Chinese population. This suggests that AA arises de novo, rather than developing from a parathyroid adenoma. Altogether, these findings will improve our understanding of the malignant potential of parathyroid tumors at the molecular level.http://dx.doi.org/10.1155/2021/6666257 |
| spellingShingle | Xinxin Mao Yan Wu Shuangni Yu Jie Chen Genetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid Adenoma International Journal of Genomics |
| title | Genetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid Adenoma |
| title_full | Genetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid Adenoma |
| title_fullStr | Genetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid Adenoma |
| title_full_unstemmed | Genetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid Adenoma |
| title_short | Genetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid Adenoma |
| title_sort | genetic alteration profiles and clinicopathological associations in atypical parathyroid adenoma |
| url | http://dx.doi.org/10.1155/2021/6666257 |
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