Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer
Background: The adipose tissue may serve as a source of energy supporting cancer growth and metastasis. Our understanding of the adipocytes which compose the adipose tissue in different anatomical locations of the body as well as potential microscopic tumor infiltration in patients with metastatic b...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977624001838 |
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| author | Hava Izci Gitte Zels Anirudh Pabba Marion Maetens François Richard Maxim De Schepper Josephine Van Cauwenberge Ha-Linh Nguyen Kristien Borremans Sophia Leduc Karen Van Baelen Sigrid Hatse Tatjana Geukens Amena Mahdami Hans Wildiers Patrick Neven Wouter Van Den Bogaert Giuseppe Floris Christine Desmedt |
| author_facet | Hava Izci Gitte Zels Anirudh Pabba Marion Maetens François Richard Maxim De Schepper Josephine Van Cauwenberge Ha-Linh Nguyen Kristien Borremans Sophia Leduc Karen Van Baelen Sigrid Hatse Tatjana Geukens Amena Mahdami Hans Wildiers Patrick Neven Wouter Van Den Bogaert Giuseppe Floris Christine Desmedt |
| author_sort | Hava Izci |
| collection | DOAJ |
| description | Background: The adipose tissue may serve as a source of energy supporting cancer growth and metastasis. Our understanding of the adipocytes which compose the adipose tissue in different anatomical locations of the body as well as potential microscopic tumor infiltration in patients with metastatic breast cancer remains limited. This study therefore investigates regional variations in adipocyte size and adipose tissue tumor infiltration in patients with metastatic breast cancer. Methods: Within the UPTIDER rapid autopsy program, (NCT04531696), 94 adipose tissue samples from subcutaneous, visceral, retroperitoneal, and mammary depots of 22 patients with metastatic breast cancer were collected and analyzed. Distant adipocyte size was quantified using digital pathology, and tumor infiltration was assessed histologically. Linear mixed quantile regression analyzed the associations between adipocyte size, fat depot type and major histological subtypes. Results: Distant adipocyte size did not significantly differ across fat depots. A trend towards smaller adipocytes in mammary fat at autopsy versus diagnosis was observed, suggesting potential age and/or treatment effects. Adipocyte size correlated positively with BMI at death, especially in subcutaneous and visceral fat. Visceral fat exhibited higher tumor infiltration, notably in patients with invasive lobular carcinoma (ILC). Conclusion: This study highlights the relatively uniform adipocyte size across fat depots in patients with metastatic breast cancer, with potential changes in mammary adipocytes over the disease course. The microscopic tumor cell infiltration observed in the visceral fat, mainly for ILC, underscores the need to undertake additional research to understanding the contribution of the adipose tissue in breast cancer metastasis. |
| format | Article |
| id | doaj-art-ae937dec76d848efab06e6dd79cc4f0e |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-ae937dec76d848efab06e6dd79cc4f0e2025-02-12T05:30:34ZengElsevierBreast1532-30802025-02-0179103852Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancerHava Izci0Gitte Zels1Anirudh Pabba2Marion Maetens3François Richard4Maxim De Schepper5Josephine Van Cauwenberge6Ha-Linh Nguyen7Kristien Borremans8Sophia Leduc9Karen Van Baelen10Sigrid Hatse11Tatjana Geukens12Amena Mahdami13Hans Wildiers14Patrick Neven15Wouter Van Den Bogaert16Giuseppe Floris17Christine Desmedt18Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Department of Pathology, University Hospitals Leuven, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Department of Pathology, University Hospitals Leuven, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, BelgiumLaboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, BelgiumDepartment of General Medical Oncology, University Hospitals Leuven, Leuven, BelgiumDepartment of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, BelgiumDepartment of Forensic Medicine, University Hospitals Leuven, Leuven, BelgiumDepartment of Pathology, University Hospitals Leuven, Leuven, BelgiumLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Corresponding author.Department of Oncology, KU Leuven, Herestraat 49, box 810, 3000, Leuven, Belgium.Background: The adipose tissue may serve as a source of energy supporting cancer growth and metastasis. Our understanding of the adipocytes which compose the adipose tissue in different anatomical locations of the body as well as potential microscopic tumor infiltration in patients with metastatic breast cancer remains limited. This study therefore investigates regional variations in adipocyte size and adipose tissue tumor infiltration in patients with metastatic breast cancer. Methods: Within the UPTIDER rapid autopsy program, (NCT04531696), 94 adipose tissue samples from subcutaneous, visceral, retroperitoneal, and mammary depots of 22 patients with metastatic breast cancer were collected and analyzed. Distant adipocyte size was quantified using digital pathology, and tumor infiltration was assessed histologically. Linear mixed quantile regression analyzed the associations between adipocyte size, fat depot type and major histological subtypes. Results: Distant adipocyte size did not significantly differ across fat depots. A trend towards smaller adipocytes in mammary fat at autopsy versus diagnosis was observed, suggesting potential age and/or treatment effects. Adipocyte size correlated positively with BMI at death, especially in subcutaneous and visceral fat. Visceral fat exhibited higher tumor infiltration, notably in patients with invasive lobular carcinoma (ILC). Conclusion: This study highlights the relatively uniform adipocyte size across fat depots in patients with metastatic breast cancer, with potential changes in mammary adipocytes over the disease course. The microscopic tumor cell infiltration observed in the visceral fat, mainly for ILC, underscores the need to undertake additional research to understanding the contribution of the adipose tissue in breast cancer metastasis.http://www.sciencedirect.com/science/article/pii/S0960977624001838Breast cancerAdipose tissueMetastasisAdipocyte sizeTumor infiltration |
| spellingShingle | Hava Izci Gitte Zels Anirudh Pabba Marion Maetens François Richard Maxim De Schepper Josephine Van Cauwenberge Ha-Linh Nguyen Kristien Borremans Sophia Leduc Karen Van Baelen Sigrid Hatse Tatjana Geukens Amena Mahdami Hans Wildiers Patrick Neven Wouter Van Den Bogaert Giuseppe Floris Christine Desmedt Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer Breast Breast cancer Adipose tissue Metastasis Adipocyte size Tumor infiltration |
| title | Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer |
| title_full | Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer |
| title_fullStr | Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer |
| title_full_unstemmed | Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer |
| title_short | Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer |
| title_sort | adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer |
| topic | Breast cancer Adipose tissue Metastasis Adipocyte size Tumor infiltration |
| url | http://www.sciencedirect.com/science/article/pii/S0960977624001838 |
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