Analytical Methods to Characterize and Purify Polymeric Nanoparticles
Advances in polymeric nanoparticles as novel nanomedicines have opened a new class of diagnostic and therapeutic tools for many diseases. However, although the benchtop research studies in the nanoworld are numerous, their translation to currently marketed products is still limited. This lack of tra...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2018/6387826 |
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| _version_ | 1832557122190049280 |
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| author | Cristina Fornaguera Conxita Solans |
| author_facet | Cristina Fornaguera Conxita Solans |
| author_sort | Cristina Fornaguera |
| collection | DOAJ |
| description | Advances in polymeric nanoparticles as novel nanomedicines have opened a new class of diagnostic and therapeutic tools for many diseases. However, although the benchtop research studies in the nanoworld are numerous, their translation to currently marketed products is still limited. This lack of transference can be attributed, among other factors, to problems with nanomedicine characterization. Characterization techniques at the nanoscale could be divided in three categories: characterization of physicochemical properties (e.g., size and surface charge), characterization of nanomaterials interactions with biological components (e.g., proteins from the blood), and analytical characterization and purification methods. Currently available literature of this last group only describes methodologies applied for a specific type of nanomaterial or even methods used for bulk materials, which are not completely applicable to nanomaterials. For this reason, the current review aims to become a scholastic guide for those scientists starting in the nanoworld, giving them a description of analytical characterization techniques aimed to analyze polymers forming nanoparticles and possible forms to purify them before being used in preclinical and clinical applications. |
| format | Article |
| id | doaj-art-ae93768ba8924a23a3e836cbfa1e8556 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-ae93768ba8924a23a3e836cbfa1e85562025-02-03T05:43:35ZengWileyInternational Journal of Polymer Science1687-94221687-94302018-01-01201810.1155/2018/63878266387826Analytical Methods to Characterize and Purify Polymeric NanoparticlesCristina Fornaguera0Conxita Solans1Grup d’Enginyeria de Materials, Institut Químic de Sarrià (IQS), Universitat Ramon Llull and Sagetis-Biotech, Via Augusta 390, 08017 Barcelona, SpainInstitute of Advanced Chemistry of Catalonia (IQAC-CSIC) and Networking Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), C/Jordi Girona 18-26, 08034 Barcelona, SpainAdvances in polymeric nanoparticles as novel nanomedicines have opened a new class of diagnostic and therapeutic tools for many diseases. However, although the benchtop research studies in the nanoworld are numerous, their translation to currently marketed products is still limited. This lack of transference can be attributed, among other factors, to problems with nanomedicine characterization. Characterization techniques at the nanoscale could be divided in three categories: characterization of physicochemical properties (e.g., size and surface charge), characterization of nanomaterials interactions with biological components (e.g., proteins from the blood), and analytical characterization and purification methods. Currently available literature of this last group only describes methodologies applied for a specific type of nanomaterial or even methods used for bulk materials, which are not completely applicable to nanomaterials. For this reason, the current review aims to become a scholastic guide for those scientists starting in the nanoworld, giving them a description of analytical characterization techniques aimed to analyze polymers forming nanoparticles and possible forms to purify them before being used in preclinical and clinical applications.http://dx.doi.org/10.1155/2018/6387826 |
| spellingShingle | Cristina Fornaguera Conxita Solans Analytical Methods to Characterize and Purify Polymeric Nanoparticles International Journal of Polymer Science |
| title | Analytical Methods to Characterize and Purify Polymeric Nanoparticles |
| title_full | Analytical Methods to Characterize and Purify Polymeric Nanoparticles |
| title_fullStr | Analytical Methods to Characterize and Purify Polymeric Nanoparticles |
| title_full_unstemmed | Analytical Methods to Characterize and Purify Polymeric Nanoparticles |
| title_short | Analytical Methods to Characterize and Purify Polymeric Nanoparticles |
| title_sort | analytical methods to characterize and purify polymeric nanoparticles |
| url | http://dx.doi.org/10.1155/2018/6387826 |
| work_keys_str_mv | AT cristinafornaguera analyticalmethodstocharacterizeandpurifypolymericnanoparticles AT conxitasolans analyticalmethodstocharacterizeandpurifypolymericnanoparticles |