Clinical and endoscopic analysis of gastrointestinal bleeding during COVID-19 full-blown pandemic: a retrospective cohort study
Background Although endoscopy is a commonly used technique in patients with gastrointestinal bleeding (GIB), there is currently insufficient evidence to inform clinicians on how to manage patients with gastrointestinal bleeding during COVID-19 full-blown pandemic. Herein, we analyzed the clinical an...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2529580 |
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| author | Jing-Wei Liu Yue Sui Jun-Hui Lu Jin-Nan Ren Jing-Wen Gong Cui-Ping Xu Yi Zhao Xing Chen |
| author_facet | Jing-Wei Liu Yue Sui Jun-Hui Lu Jin-Nan Ren Jing-Wen Gong Cui-Ping Xu Yi Zhao Xing Chen |
| author_sort | Jing-Wei Liu |
| collection | DOAJ |
| description | Background Although endoscopy is a commonly used technique in patients with gastrointestinal bleeding (GIB), there is currently insufficient evidence to inform clinicians on how to manage patients with gastrointestinal bleeding during COVID-19 full-blown pandemic. Herein, we analyzed the clinical and endoscopic characteristics of GIB in patients hospitalized during COVID-19 full-blown pandemic.Methods Patients with GIB during the initial stage of COVID-19 pandemic and COVID-19 full-blown pandemic were enrolled and defined as Group 1 and Group 2, respectively. Comeparing the differences in the 30 days mortality, the need for intensive care unit (ICU) level of care, laboratory examination, blood transfusion and anticoagulant therapy, use of non-steroidal anti-inflammatory drugs (NSAIDs), frequency of endoscopy, and examination results between the two groups.Results Compared to GIB patients in initial stage of COVID-19 pandemic, prothrombin time (PT) (15.45 s vs 13.84 s, p = 0.003), activated partial prothrombin time (APTT) (33.13 s vs 27.28 s, p = 0.001), d-dimer (mg/L) (730.44 vs 507.22, p = 0.041), and prothrombin activity (PTA) (75.79% vs 76.61%, p = 0.001) were higher in GIB patients during COVID-19 pandemic. Furthermore, an increased need for ICU stays (%) (16.9% vs 3.8%, p = 0.020) and anticoagulant therapy (%) (38.2% vs 5.7%, p < 0.001), higher use of NSAIDs (%) (25.8% vs 3.8%, p = 0.001) and lower frequency of endoscopy (%) (41.6% vs 73.6%, p < 0.001) were seen during COVID-19 full-blown pandemic.Conclusion During COVID-19 full-blown pandemic, the number of patients with GIB increased significantly; these patients were more likely to require ICU admission. Although the endoscopic intervention rate was significantly reduced in COVID-19 patients, there were no significant differences in hospital stay, blood transfusion requirements, rebleeding rate, and mortality. |
| format | Article |
| id | doaj-art-ae8bc6af321d4b5382bd56f14f9ea18c |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-ae8bc6af321d4b5382bd56f14f9ea18c2025-08-20T03:50:32ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2529580Clinical and endoscopic analysis of gastrointestinal bleeding during COVID-19 full-blown pandemic: a retrospective cohort studyJing-Wei Liu0Yue Sui1Jun-Hui Lu2Jin-Nan Ren3Jing-Wen Gong4Cui-Ping Xu5Yi Zhao6Xing Chen7The First Clinical Medical College, Shanxi Medical University, Taiyuan, ChinaThe First Clinical Medical College, Shanxi Medical University, Taiyuan, ChinaThe First Clinical Medical College, Shanxi Medical University, Taiyuan, ChinaDepartment of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan, ChinaThe First Clinical Medical College, Shanxi Medical University, Taiyuan, ChinaBackground Although endoscopy is a commonly used technique in patients with gastrointestinal bleeding (GIB), there is currently insufficient evidence to inform clinicians on how to manage patients with gastrointestinal bleeding during COVID-19 full-blown pandemic. Herein, we analyzed the clinical and endoscopic characteristics of GIB in patients hospitalized during COVID-19 full-blown pandemic.Methods Patients with GIB during the initial stage of COVID-19 pandemic and COVID-19 full-blown pandemic were enrolled and defined as Group 1 and Group 2, respectively. Comeparing the differences in the 30 days mortality, the need for intensive care unit (ICU) level of care, laboratory examination, blood transfusion and anticoagulant therapy, use of non-steroidal anti-inflammatory drugs (NSAIDs), frequency of endoscopy, and examination results between the two groups.Results Compared to GIB patients in initial stage of COVID-19 pandemic, prothrombin time (PT) (15.45 s vs 13.84 s, p = 0.003), activated partial prothrombin time (APTT) (33.13 s vs 27.28 s, p = 0.001), d-dimer (mg/L) (730.44 vs 507.22, p = 0.041), and prothrombin activity (PTA) (75.79% vs 76.61%, p = 0.001) were higher in GIB patients during COVID-19 pandemic. Furthermore, an increased need for ICU stays (%) (16.9% vs 3.8%, p = 0.020) and anticoagulant therapy (%) (38.2% vs 5.7%, p < 0.001), higher use of NSAIDs (%) (25.8% vs 3.8%, p = 0.001) and lower frequency of endoscopy (%) (41.6% vs 73.6%, p < 0.001) were seen during COVID-19 full-blown pandemic.Conclusion During COVID-19 full-blown pandemic, the number of patients with GIB increased significantly; these patients were more likely to require ICU admission. Although the endoscopic intervention rate was significantly reduced in COVID-19 patients, there were no significant differences in hospital stay, blood transfusion requirements, rebleeding rate, and mortality.https://www.tandfonline.com/doi/10.1080/07853890.2025.2529580COVID-19 infectionfull-blown pandemicgastrointestinal bleedingmortalitycoagulation functionendoscopy examination |
| spellingShingle | Jing-Wei Liu Yue Sui Jun-Hui Lu Jin-Nan Ren Jing-Wen Gong Cui-Ping Xu Yi Zhao Xing Chen Clinical and endoscopic analysis of gastrointestinal bleeding during COVID-19 full-blown pandemic: a retrospective cohort study Annals of Medicine COVID-19 infection full-blown pandemic gastrointestinal bleeding mortality coagulation function endoscopy examination |
| title | Clinical and endoscopic analysis of gastrointestinal bleeding during COVID-19 full-blown pandemic: a retrospective cohort study |
| title_full | Clinical and endoscopic analysis of gastrointestinal bleeding during COVID-19 full-blown pandemic: a retrospective cohort study |
| title_fullStr | Clinical and endoscopic analysis of gastrointestinal bleeding during COVID-19 full-blown pandemic: a retrospective cohort study |
| title_full_unstemmed | Clinical and endoscopic analysis of gastrointestinal bleeding during COVID-19 full-blown pandemic: a retrospective cohort study |
| title_short | Clinical and endoscopic analysis of gastrointestinal bleeding during COVID-19 full-blown pandemic: a retrospective cohort study |
| title_sort | clinical and endoscopic analysis of gastrointestinal bleeding during covid 19 full blown pandemic a retrospective cohort study |
| topic | COVID-19 infection full-blown pandemic gastrointestinal bleeding mortality coagulation function endoscopy examination |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2529580 |
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