Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics study
Abstract HMGA1 plays an important role in a variety of biological processes. However, it is still unclear what role HMGA1 plays in HNSCC. By integrating multi-omics data from public and private cohorts, we conducted a comprehensive analysis. The results showed that HMGA1 expression was significantly...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-025-01068-4 |
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| author | Ziang Xu Moxu Wang Jilin Cai Tianxiao Wang Nan Ni Tao Liu Maojie Xue Xiang Wang Zhixuan Liu Hua Yuan Wei Zhang Ruyang Zhang |
| author_facet | Ziang Xu Moxu Wang Jilin Cai Tianxiao Wang Nan Ni Tao Liu Maojie Xue Xiang Wang Zhixuan Liu Hua Yuan Wei Zhang Ruyang Zhang |
| author_sort | Ziang Xu |
| collection | DOAJ |
| description | Abstract HMGA1 plays an important role in a variety of biological processes. However, it is still unclear what role HMGA1 plays in HNSCC. By integrating multi-omics data from public and private cohorts, we conducted a comprehensive analysis. The results showed that HMGA1 expression was significantly higher in HNSCC tumor tissue, correlated with poor prognosis. Increased HMGA1 expression indicated distinct somatic mutations and heavier tumor mutation burden, meanwhile, had significant interaction with several immune checkpoints. Single-cell analysis suggested that HMGA1 was highly enriched in malignant cells. In-vitro and in-vivo experiments also suggested that HMGA1 promoted the proliferation, migration and activation of HNSCC cells. Upstream analysis showed that cg25207224 HMGA1 tested by oral rinse specimen maybe a non-invasive in-vitro predictive marker for prognostic prediction of HNSCC. Our study revealed the impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC from a multi-omics perspective and provided a therapeutic target for HNSCC patients. |
| format | Article |
| id | doaj-art-ae8abe2c02ff4e9fa0099d780af45e38 |
| institution | Kabale University |
| issn | 2397-768X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj-art-ae8abe2c02ff4e9fa0099d780af45e382025-08-20T04:01:44ZengNature Portfolionpj Precision Oncology2397-768X2025-08-019111510.1038/s41698-025-01068-4Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics studyZiang Xu0Moxu Wang1Jilin Cai2Tianxiao Wang3Nan Ni4Tao Liu5Maojie Xue6Xiang Wang7Zhixuan Liu8Hua Yuan9Wei Zhang10Ruyang Zhang11State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical UniversityState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical UniversityAbstract HMGA1 plays an important role in a variety of biological processes. However, it is still unclear what role HMGA1 plays in HNSCC. By integrating multi-omics data from public and private cohorts, we conducted a comprehensive analysis. The results showed that HMGA1 expression was significantly higher in HNSCC tumor tissue, correlated with poor prognosis. Increased HMGA1 expression indicated distinct somatic mutations and heavier tumor mutation burden, meanwhile, had significant interaction with several immune checkpoints. Single-cell analysis suggested that HMGA1 was highly enriched in malignant cells. In-vitro and in-vivo experiments also suggested that HMGA1 promoted the proliferation, migration and activation of HNSCC cells. Upstream analysis showed that cg25207224 HMGA1 tested by oral rinse specimen maybe a non-invasive in-vitro predictive marker for prognostic prediction of HNSCC. Our study revealed the impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC from a multi-omics perspective and provided a therapeutic target for HNSCC patients.https://doi.org/10.1038/s41698-025-01068-4 |
| spellingShingle | Ziang Xu Moxu Wang Jilin Cai Tianxiao Wang Nan Ni Tao Liu Maojie Xue Xiang Wang Zhixuan Liu Hua Yuan Wei Zhang Ruyang Zhang Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics study npj Precision Oncology |
| title | Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics study |
| title_full | Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics study |
| title_fullStr | Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics study |
| title_full_unstemmed | Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics study |
| title_short | Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics study |
| title_sort | impact of hmga1 on tumorigenesis prognosis and immune microenvironment in hnscc a multi omics study |
| url | https://doi.org/10.1038/s41698-025-01068-4 |
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