Identification of foam cell like M2 macrophages, AEBP1 biomarkers, and resveratrol as potential therapeutic in MASLD using Ecotyper and WGCNA

Identification of foam cell like M2 macrophages, AEBP1 biomarkers, and resveratrol as potential therapeutic in MASLD using Ecotyper and WGCNA

Abstract The immune cell landscapes in metabolic dysfunction-associated fatty liver disease (MAFLD) and their clinical relevance have not been explored. We used Ecotyper to identify immune cell states based on gene expression and examined their roles in metabolic dysfunction–associated steatotic liv...

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Bibliographic Details
Main Authors: Hua Ye, Mengxia Sun, Wenjing Luo, Dahua Chen, Jiacheng Cai, Jia Dong, Liangshun Zhang, Huiwei Liu, Jinyu Kang, Feng Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
MAFLD
Ecotyper
Resveratrol
Fibroblasts
Immune cell landscapes
Online Access:https://doi.org/10.1038/s41598-025-15191-6
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