Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review
Metabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma. Mental and behavioral abnormalities are prevalent manifestations, accompanied by cognitive im...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1436246/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849721775846326272 |
|---|---|
| author | Yixin Gu Yixin Gu Tingting Xuan Tingting Xuan Pankui Li Pankui Li Jing Zhou Jing Zhou Zhenhai Wang Zhenhai Wang |
| author_facet | Yixin Gu Yixin Gu Tingting Xuan Tingting Xuan Pankui Li Pankui Li Jing Zhou Jing Zhou Zhenhai Wang Zhenhai Wang |
| author_sort | Yixin Gu |
| collection | DOAJ |
| description | Metabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma. Mental and behavioral abnormalities are prevalent manifestations, accompanied by cognitive impairment, movement disorders, seizures, and other associated symptoms. In this report, we present the case of a young female patient who presented with abnormal mental behavior, seizures, and disturbances of consciousness. A cell-based assay (CBA) showed positive IgG metabotropic glutamate receptor 5 in both her serum and cerebrospinal fluid (CSF), as well as positive IgG N-methyl-D-aspartate receptor (NMDAR) in both her serum and CSF. She was diagnosed with mGluR5 overlapping NMDAR antibody encephalitis and received high-dose intravenous methylprednisolone pulse therapy and immunoglobulin therapy. Tumor screening suggested the presence of bilateral ovarian teratoma. However, unfortunately the prognosis was extremely poor. Clinical results suggested that patients with mGluR5-Abs mostly have good prognoses, excepting our case. |
| format | Article |
| id | doaj-art-ae8523cddc6b45808bb5dc29fe8e9b97 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ae8523cddc6b45808bb5dc29fe8e9b972025-08-20T03:11:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.14362461436246Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature reviewYixin Gu0Yixin Gu1Tingting Xuan2Tingting Xuan3Pankui Li4Pankui Li5Jing Zhou6Jing Zhou7Zhenhai Wang8Zhenhai Wang9School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, ChinaDiagnosis and Treatment Engineering Technology Research Center of Nervous System Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaSchool of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, ChinaDiagnosis and Treatment Engineering Technology Research Center of Nervous System Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaSchool of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, ChinaDiagnosis and Treatment Engineering Technology Research Center of Nervous System Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaSchool of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, ChinaDiagnosis and Treatment Engineering Technology Research Center of Nervous System Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaDiagnosis and Treatment Engineering Technology Research Center of Nervous System Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaDepartment of Neurology, General Hospital of Ningxia Medical University, Yinchuan, ChinaMetabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma. Mental and behavioral abnormalities are prevalent manifestations, accompanied by cognitive impairment, movement disorders, seizures, and other associated symptoms. In this report, we present the case of a young female patient who presented with abnormal mental behavior, seizures, and disturbances of consciousness. A cell-based assay (CBA) showed positive IgG metabotropic glutamate receptor 5 in both her serum and cerebrospinal fluid (CSF), as well as positive IgG N-methyl-D-aspartate receptor (NMDAR) in both her serum and CSF. She was diagnosed with mGluR5 overlapping NMDAR antibody encephalitis and received high-dose intravenous methylprednisolone pulse therapy and immunoglobulin therapy. Tumor screening suggested the presence of bilateral ovarian teratoma. However, unfortunately the prognosis was extremely poor. Clinical results suggested that patients with mGluR5-Abs mostly have good prognoses, excepting our case.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1436246/fullautoimmune encephalitismetabotropic glutamate receptor 5antibody overlapovarian teratomacase report |
| spellingShingle | Yixin Gu Yixin Gu Tingting Xuan Tingting Xuan Pankui Li Pankui Li Jing Zhou Jing Zhou Zhenhai Wang Zhenhai Wang Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review Frontiers in Immunology autoimmune encephalitis metabotropic glutamate receptor 5 antibody overlap ovarian teratoma case report |
| title | Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review |
| title_full | Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review |
| title_fullStr | Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review |
| title_full_unstemmed | Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review |
| title_short | Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review |
| title_sort | anti metabotropic glutamate receptor 5 coexistent anti n methyl d aspartate receptor encephalitis a case report and literature review |
| topic | autoimmune encephalitis metabotropic glutamate receptor 5 antibody overlap ovarian teratoma case report |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1436246/full |
| work_keys_str_mv | AT yixingu antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview AT yixingu antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview AT tingtingxuan antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview AT tingtingxuan antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview AT pankuili antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview AT pankuili antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview AT jingzhou antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview AT jingzhou antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview AT zhenhaiwang antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview AT zhenhaiwang antimetabotropicglutamatereceptor5coexistentantinmethyldaspartatereceptorencephalitisacasereportandliteraturereview |