Adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next-generation sequencing: A case report
Staphylococcus aureus is an uncommon cause of bacterial meningitis, and S. aureus meningitis complicated with adynamic ileus has not been previously documented. This report presents a rare case of a man in his late 30s who developed purulent meningitis and intestinal pseudo-obstruction secondary to...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-08-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605251365895 |
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| author | Tonger Liang Junjie Situ Hanqiao Qin Jia Peng |
| author_facet | Tonger Liang Junjie Situ Hanqiao Qin Jia Peng |
| author_sort | Tonger Liang |
| collection | DOAJ |
| description | Staphylococcus aureus is an uncommon cause of bacterial meningitis, and S. aureus meningitis complicated with adynamic ileus has not been previously documented. This report presents a rare case of a man in his late 30s who developed purulent meningitis and intestinal pseudo-obstruction secondary to a skin-derived S. aureus infection. The patient initially presented with persistent fever, headache, and altered mental status. Subsequently, he developed abdominal distention, vomiting, dysuria, and meningeal signs. Laboratory tests revealed hyponatremia and elevated cerebrospinal fluid pressure; however, conventional cerebrospinal fluid culture failed to detect any pathogen. Diagnosis was ultimately confirmed through metagenomic next-generation sequencing, which identified S. aureus as the causative agent. Targeted antimicrobial therapy with vancomycin and meropenem resulted in rapid clinical improvement. This case highlights the importance of considering central nervous system infections in patients presenting with unexplained gastrointestinal and autonomic symptoms. Moreover, it emphasizes the clinical utility of metagenomic next-generation sequencing in identifying pathogens in culture-negative, atypical infections. Early recognition and intervention are essential to improving outcomes in such complex presentations. |
| format | Article |
| id | doaj-art-ae82b160ea1b4e23ab040b72e8970911 |
| institution | DOAJ |
| issn | 1473-2300 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-ae82b160ea1b4e23ab040b72e89709112025-08-20T03:02:59ZengSAGE PublishingJournal of International Medical Research1473-23002025-08-015310.1177/03000605251365895Adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next-generation sequencing: A case reportTonger LiangJunjie SituHanqiao QinJia PengStaphylococcus aureus is an uncommon cause of bacterial meningitis, and S. aureus meningitis complicated with adynamic ileus has not been previously documented. This report presents a rare case of a man in his late 30s who developed purulent meningitis and intestinal pseudo-obstruction secondary to a skin-derived S. aureus infection. The patient initially presented with persistent fever, headache, and altered mental status. Subsequently, he developed abdominal distention, vomiting, dysuria, and meningeal signs. Laboratory tests revealed hyponatremia and elevated cerebrospinal fluid pressure; however, conventional cerebrospinal fluid culture failed to detect any pathogen. Diagnosis was ultimately confirmed through metagenomic next-generation sequencing, which identified S. aureus as the causative agent. Targeted antimicrobial therapy with vancomycin and meropenem resulted in rapid clinical improvement. This case highlights the importance of considering central nervous system infections in patients presenting with unexplained gastrointestinal and autonomic symptoms. Moreover, it emphasizes the clinical utility of metagenomic next-generation sequencing in identifying pathogens in culture-negative, atypical infections. Early recognition and intervention are essential to improving outcomes in such complex presentations.https://doi.org/10.1177/03000605251365895 |
| spellingShingle | Tonger Liang Junjie Situ Hanqiao Qin Jia Peng Adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next-generation sequencing: A case report Journal of International Medical Research |
| title | Adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next-generation sequencing: A case report |
| title_full | Adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next-generation sequencing: A case report |
| title_fullStr | Adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next-generation sequencing: A case report |
| title_full_unstemmed | Adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next-generation sequencing: A case report |
| title_short | Adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next-generation sequencing: A case report |
| title_sort | adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next generation sequencing a case report |
| url | https://doi.org/10.1177/03000605251365895 |
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