Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia
Introduction: Somalia is among the countries with a high burden of human papillomavirus (HPV) infection in Sub-Saharan Africa. In 2022, 660,000 infections are reported among women globally, out of which 350,000 died from the disease. Most of the studies on HPV reported from Somalia are based on cyt...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Journal of Infection in Developing Countries
2024-11-01
|
| Series: | Journal of Infection in Developing Countries |
| Subjects: | |
| Online Access: | https://jidc.org/index.php/journal/article/view/19982 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849313752266047488 |
|---|---|
| author | Bashiru Garba Maryan A Sh Nur Maryam Adawe Mohamed H Adam Jamal H Mohamoud Hassan A Dahie Mohamed M Ahmed Abdirahman K Mohamud Sadio A Mohamed Fartun AH Orey Jihaan Hassan Hodo A Asowe Najib I Dirie |
| author_facet | Bashiru Garba Maryan A Sh Nur Maryam Adawe Mohamed H Adam Jamal H Mohamoud Hassan A Dahie Mohamed M Ahmed Abdirahman K Mohamud Sadio A Mohamed Fartun AH Orey Jihaan Hassan Hodo A Asowe Najib I Dirie |
| author_sort | Bashiru Garba |
| collection | DOAJ |
| description |
Introduction: Somalia is among the countries with a high burden of human papillomavirus (HPV) infection in Sub-Saharan Africa. In 2022, 660,000 infections are reported among women globally, out of which 350,000 died from the disease. Most of the studies on HPV reported from Somalia are based on cytologic analysis which is a subjective and suboptimal assessment. The recent World Health Organization (WHO) guidelines for HPV recommend DNA-based testing as a better alternative to the traditional pap smear test.
Methodology: This study was undertaken to determine the prevalence of HPV based on the preferred HPV DNA assay on cervical samples of women of reproductive age in Mogadishu, Somalia. The HPV DNA detection was carried out using real-time quantitative polymerase chain reaction (RT-PCR) assays to identify high-risk oncogenic HPV16, HPV18, and other high-risk HPV types.
Results: Overall, 31.7% (60/189) of cervical samples were positive for HPV DNA. Out of this, 19.6% were high risk-HPV (hrHPV), 13.8% were HPV16, and 5.3% were HPV18. Moreover, age, income and education level were found to be significant risk factors for HPV infection.
Conclusions: These results provide further proof that HPV continues to be a serious public health challenge in Somalia with the risk of progressing to fatal cervical cancer.
|
| format | Article |
| id | doaj-art-ae81464225634e958cfd4be6cafa74df |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ae81464225634e958cfd4be6cafa74df2025-08-20T03:52:39ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-11-01181110.3855/jidc.19982Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, SomaliaBashiru Garba0Maryan A Sh Nur1Maryam Adawe2Mohamed H Adam3Jamal H Mohamoud4Hassan A Dahie5Mohamed M Ahmed6Abdirahman K Mohamud7Sadio A Mohamed8Fartun AH Orey9Jihaan Hassan10Hodo A Asowe11Najib I Dirie12Department of Public Health, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, SomaliaDepartment of Obstetrics and Gynecology, Dr. Sumait Hospital, SIMAD University, Mogadishu, SomaliaDepartment of Obstetrics and Gynecology, Dr. Sumait Hospital, SIMAD University, Mogadishu, SomaliaDepartment of Public Health, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, SomaliaDepartment of Public Health, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, SomaliaDepartment of Nursing and Midwifery, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, SomaliaDepartment of Medicine and Surgery, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, SomaliaDepartment of Public Health, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, SomaliaDepartment of Obstetrics and Gynecology, Dr. Sumait Hospital, SIMAD University, Mogadishu, SomaliaDepartment of Pediatrics and Child Health, Dr Sumait Hospital, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, SomaliaDepartment of Medicine and Surgery, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, SomaliaDepartment of Nursing and Midwifery, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, SomaliaDepartment of Urology, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia Introduction: Somalia is among the countries with a high burden of human papillomavirus (HPV) infection in Sub-Saharan Africa. In 2022, 660,000 infections are reported among women globally, out of which 350,000 died from the disease. Most of the studies on HPV reported from Somalia are based on cytologic analysis which is a subjective and suboptimal assessment. The recent World Health Organization (WHO) guidelines for HPV recommend DNA-based testing as a better alternative to the traditional pap smear test. Methodology: This study was undertaken to determine the prevalence of HPV based on the preferred HPV DNA assay on cervical samples of women of reproductive age in Mogadishu, Somalia. The HPV DNA detection was carried out using real-time quantitative polymerase chain reaction (RT-PCR) assays to identify high-risk oncogenic HPV16, HPV18, and other high-risk HPV types. Results: Overall, 31.7% (60/189) of cervical samples were positive for HPV DNA. Out of this, 19.6% were high risk-HPV (hrHPV), 13.8% were HPV16, and 5.3% were HPV18. Moreover, age, income and education level were found to be significant risk factors for HPV infection. Conclusions: These results provide further proof that HPV continues to be a serious public health challenge in Somalia with the risk of progressing to fatal cervical cancer. https://jidc.org/index.php/journal/article/view/19982human papillomaviruscervical cancerrisk factorsHPV-DNASomalia |
| spellingShingle | Bashiru Garba Maryan A Sh Nur Maryam Adawe Mohamed H Adam Jamal H Mohamoud Hassan A Dahie Mohamed M Ahmed Abdirahman K Mohamud Sadio A Mohamed Fartun AH Orey Jihaan Hassan Hodo A Asowe Najib I Dirie Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia Journal of Infection in Developing Countries human papillomavirus cervical cancer risk factors HPV-DNA Somalia |
| title | Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia |
| title_full | Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia |
| title_fullStr | Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia |
| title_full_unstemmed | Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia |
| title_short | Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia |
| title_sort | human papillomavirus dna detection in cervical samples from women of reproductive age in mogadishu somalia |
| topic | human papillomavirus cervical cancer risk factors HPV-DNA Somalia |
| url | https://jidc.org/index.php/journal/article/view/19982 |
| work_keys_str_mv | AT bashirugarba humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT maryanashnur humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT maryamadawe humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT mohamedhadam humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT jamalhmohamoud humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT hassanadahie humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT mohamedmahmed humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT abdirahmankmohamud humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT sadioamohamed humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT fartunahorey humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT jihaanhassan humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT hodoaasowe humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia AT najibidirie humanpapillomavirusdnadetectionincervicalsamplesfromwomenofreproductiveageinmogadishusomalia |