Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia

Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia

Introduction: Somalia is among the countries with a high burden of human papillomavirus (HPV) infection in Sub-Saharan Africa. In 2022, 660,000 infections are reported among women globally, out of which 350,000 died from the disease. Most of the studies on HPV reported from Somalia are based on cyt...

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Main Authors: Bashiru Garba, Maryan A Sh Nur, Maryam Adawe, Mohamed H Adam, Jamal H Mohamoud, Hassan A Dahie, Mohamed M Ahmed, Abdirahman K Mohamud, Sadio A Mohamed, Fartun AH Orey, Jihaan Hassan, Hodo A Asowe, Najib I Dirie
Format: Article
Language:English
Published: The Journal of Infection in Developing Countries 2024-11-01
Series:Journal of Infection in Developing Countries
Subjects:
human papillomavirus
cervical cancer
risk factors
HPV-DNA
Somalia
Online Access:https://jidc.org/index.php/journal/article/view/19982
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Summary:Introduction: Somalia is among the countries with a high burden of human papillomavirus (HPV) infection in Sub-Saharan Africa. In 2022, 660,000 infections are reported among women globally, out of which 350,000 died from the disease. Most of the studies on HPV reported from Somalia are based on cytologic analysis which is a subjective and suboptimal assessment. The recent World Health Organization (WHO) guidelines for HPV recommend DNA-based testing as a better alternative to the traditional pap smear test. Methodology: This study was undertaken to determine the prevalence of HPV based on the preferred HPV DNA assay on cervical samples of women of reproductive age in Mogadishu, Somalia. The HPV DNA detection was carried out using real-time quantitative polymerase chain reaction (RT-PCR) assays to identify high-risk oncogenic HPV16, HPV18, and other high-risk HPV types. Results: Overall, 31.7% (60/189) of cervical samples were positive for HPV DNA. Out of this, 19.6% were high risk-HPV (hrHPV), 13.8% were HPV16, and 5.3% were HPV18. Moreover, age, income and education level were found to be significant risk factors for HPV infection. Conclusions: These results provide further proof that HPV continues to be a serious public health challenge in Somalia with the risk of progressing to fatal cervical cancer.
ISSN:1972-2680

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