Colorectal polyp prevalence and adenoma detection rates in an Iranian cohort: a prospective study
Abstract Background Colorectal cancer (CRC) prevention relies on early diagnosis and endoscopic resection of adenomatous polyps. This in turn depends on the quality of the performed colonoscopy. “Polyp detection rate, PDR” and “adenoma detection rate, ADR” are considered indices for quality of colon...
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BMC
2025-07-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-04032-5 |
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| author | Amir-Hossein Mousavian Anahita Sadeghi Amir Kasaeian Maryam Rayatpisheh Sepideh Nikfam Marziyeh Malek Reza Malekzadeh Siavosh Nasseri-Moghaddam |
| author_facet | Amir-Hossein Mousavian Anahita Sadeghi Amir Kasaeian Maryam Rayatpisheh Sepideh Nikfam Marziyeh Malek Reza Malekzadeh Siavosh Nasseri-Moghaddam |
| author_sort | Amir-Hossein Mousavian |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC) prevention relies on early diagnosis and endoscopic resection of adenomatous polyps. This in turn depends on the quality of the performed colonoscopy. “Polyp detection rate, PDR” and “adenoma detection rate, ADR” are considered indices for quality of colonoscopy. This study aims to evaluate PDR and ADR, alongside the demographic, clinical, and pathological characteristics of colorectal polyps in an Iranian population. We also aimed to find the prevalence of colon polyps among different age groups. Methods All consenting patients 40 years of age or older undergoing screening colonoscopy or for possible IBS in a referral center in Tehran over 10 years were enrolled. We collected demographic data, quality of colon preparation, time to cecum, withdrawal time and colonoscopic findings. PDR and ADR were calculated and correlated with the above-mentioned indices. Results A total of 3,416 (mean age 57.6 ± 9.8 years) people meeting the inclusion criteria were enrolled. Successful ileal intubation occurred in 54.6%. PDR was 41.5% (95% CI: 39.9–43.3%) being higher in men (46.8% vs. 36.9%; p = 0.01). Individuals aged 45–49 years exhibited a greater likelihood of colorectal polyps than younger counterparts (34.2% vs. 21.9%, p = 0.001). Overall ADR was 26.4% (95% CI: 25.01-27.9%), with patients older than 50 years having a higher rate (29.3% vs. 16.3%). Conclusion Our data shows acceptable PDR and ADR in this referral center and higher prevalence of adenomatous polyps in men in accordance with western reports. In addition, according to our data substantial proportion of individuals aged 45–49 years were found to harbor adenomatous polyps, aligning with trends observed in Western populations. If further research confirms these findings, it could provide a rationale for considering the initiation of colorectal cancer screening at age 45 in Iran. |
| format | Article |
| id | doaj-art-ae7540d4d73e401bb4f091e19fb07439 |
| institution | DOAJ |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-07-01 |
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| series | BMC Gastroenterology |
| spelling | doaj-art-ae7540d4d73e401bb4f091e19fb074392025-08-20T03:03:33ZengBMCBMC Gastroenterology1471-230X2025-07-012511610.1186/s12876-025-04032-5Colorectal polyp prevalence and adenoma detection rates in an Iranian cohort: a prospective studyAmir-Hossein Mousavian0Anahita Sadeghi1Amir Kasaeian2Maryam Rayatpisheh3Sepideh Nikfam4Marziyeh Malek5Reza Malekzadeh6Siavosh Nasseri-Moghaddam7Digestive Disease Research Institute, Tehran University of Medical SciencesDigestive Disease Research Institute, Tehran University of Medical SciencesLiver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical SciencesDigestive Disease Research Institute, Tehran University of Medical SciencesDigestive Disease Research Institute, Tehran University of Medical SciencesDigestive Disease Research Institute, Tehran University of Medical SciencesDigestive Disease Research Institute, Tehran University of Medical SciencesDigestive Disease Research Institute, Tehran University of Medical SciencesAbstract Background Colorectal cancer (CRC) prevention relies on early diagnosis and endoscopic resection of adenomatous polyps. This in turn depends on the quality of the performed colonoscopy. “Polyp detection rate, PDR” and “adenoma detection rate, ADR” are considered indices for quality of colonoscopy. This study aims to evaluate PDR and ADR, alongside the demographic, clinical, and pathological characteristics of colorectal polyps in an Iranian population. We also aimed to find the prevalence of colon polyps among different age groups. Methods All consenting patients 40 years of age or older undergoing screening colonoscopy or for possible IBS in a referral center in Tehran over 10 years were enrolled. We collected demographic data, quality of colon preparation, time to cecum, withdrawal time and colonoscopic findings. PDR and ADR were calculated and correlated with the above-mentioned indices. Results A total of 3,416 (mean age 57.6 ± 9.8 years) people meeting the inclusion criteria were enrolled. Successful ileal intubation occurred in 54.6%. PDR was 41.5% (95% CI: 39.9–43.3%) being higher in men (46.8% vs. 36.9%; p = 0.01). Individuals aged 45–49 years exhibited a greater likelihood of colorectal polyps than younger counterparts (34.2% vs. 21.9%, p = 0.001). Overall ADR was 26.4% (95% CI: 25.01-27.9%), with patients older than 50 years having a higher rate (29.3% vs. 16.3%). Conclusion Our data shows acceptable PDR and ADR in this referral center and higher prevalence of adenomatous polyps in men in accordance with western reports. In addition, according to our data substantial proportion of individuals aged 45–49 years were found to harbor adenomatous polyps, aligning with trends observed in Western populations. If further research confirms these findings, it could provide a rationale for considering the initiation of colorectal cancer screening at age 45 in Iran.https://doi.org/10.1186/s12876-025-04032-5Colorectal cancerScreeningPolyp detectionAdenoma detection |
| spellingShingle | Amir-Hossein Mousavian Anahita Sadeghi Amir Kasaeian Maryam Rayatpisheh Sepideh Nikfam Marziyeh Malek Reza Malekzadeh Siavosh Nasseri-Moghaddam Colorectal polyp prevalence and adenoma detection rates in an Iranian cohort: a prospective study BMC Gastroenterology Colorectal cancer Screening Polyp detection Adenoma detection |
| title | Colorectal polyp prevalence and adenoma detection rates in an Iranian cohort: a prospective study |
| title_full | Colorectal polyp prevalence and adenoma detection rates in an Iranian cohort: a prospective study |
| title_fullStr | Colorectal polyp prevalence and adenoma detection rates in an Iranian cohort: a prospective study |
| title_full_unstemmed | Colorectal polyp prevalence and adenoma detection rates in an Iranian cohort: a prospective study |
| title_short | Colorectal polyp prevalence and adenoma detection rates in an Iranian cohort: a prospective study |
| title_sort | colorectal polyp prevalence and adenoma detection rates in an iranian cohort a prospective study |
| topic | Colorectal cancer Screening Polyp detection Adenoma detection |
| url | https://doi.org/10.1186/s12876-025-04032-5 |
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