Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women
Studies suggest that ACE-inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) may preserve skeletal muscle with aging. We evaluated longitudinal differences in lean body mass (LBM) among women diagnosed with hypertension and classified as ACE-I/ARB users and nonusers among Women’s Health Init...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8491092 |
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| author | Jennifer W. Bea Sylvia Wassertheil-Smoller Betsy C. Wertheim Yann Klimentidis Zhao Chen Oleg Zaslavsky Todd M. Manini Catherine R. Womack Candyce H. Kroenke Andrea Z. LaCroix Cynthia A. Thomson |
| author_facet | Jennifer W. Bea Sylvia Wassertheil-Smoller Betsy C. Wertheim Yann Klimentidis Zhao Chen Oleg Zaslavsky Todd M. Manini Catherine R. Womack Candyce H. Kroenke Andrea Z. LaCroix Cynthia A. Thomson |
| author_sort | Jennifer W. Bea |
| collection | DOAJ |
| description | Studies suggest that ACE-inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) may preserve skeletal muscle with aging. We evaluated longitudinal differences in lean body mass (LBM) among women diagnosed with hypertension and classified as ACE-I/ARB users and nonusers among Women’s Health Initiative participants that received dual energy X-ray absorptiometry scans to estimate body composition (n=10,635) at baseline and at years 3 and 6 of follow-up. Of those, 2642 were treated for hypertension at baseline. Multivariate linear regression models, adjusted for relevant demographics, behaviors, and medications, assessed ACE-I/ARB use/nonuse and LBM associations at baseline, as well as change in LBM over 3 and 6 years. Although BMI did not differ by ACE-I/ARB use, LBM (%) was significantly higher in ACE-I/ARB users versus nonusers at baseline (52.2% versus 51.3%, resp., p=0.001). There was no association between ACE-I/ARB usage and change in LBM over time. Reasons for higher LBM with ACE-I/ARB use cross sectionally, but not longitundinally, are unclear and may reflect a threshold effect of these medications on LBM that is attenuated over time. Nevertheless, ACE-I/ARB use does not appear to negatively impact LBM in the long term. |
| format | Article |
| id | doaj-art-ae73cfeb340c4ea1999db930dcdc8f15 |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-ae73cfeb340c4ea1999db930dcdc8f152025-02-03T06:00:31ZengWileyJournal of Aging Research2090-22042090-22122018-01-01201810.1155/2018/84910928491092Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older WomenJennifer W. Bea0Sylvia Wassertheil-Smoller1Betsy C. Wertheim2Yann Klimentidis3Zhao Chen4Oleg Zaslavsky5Todd M. Manini6Catherine R. Womack7Candyce H. Kroenke8Andrea Z. LaCroix9Cynthia A. Thomson10University of Arizona Cancer Center, 1515 N. Campbell Ave, P.O. Box 245024, Tucson, AZ 85724-0524, USADepartment of Epidemiology and Population Health, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Belfer Building, Room 1308B, Bronx, NY 10461, USAUniversity of Arizona Cancer Center, 1515 N. Campbell Ave, P.O. Box 245024, Tucson, AZ 85724-0524, USADepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin, P.O. Box 245211, Drachman Hall A238, Tucson, AZ 85724, USADepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin, P.O. Box 245211, Drachman Hall A238, Tucson, AZ 85724, USADepartment of Biobehavioral Nursing and Health Systems, University of Washington, P.O Box 357266, 1959 NE Pacific Ave., Seattle, WA 98195-7266, USADepartment of Aging and Geriatric Research, University of Florida, P.O. Box 100107, Gainesville, FL 32610, USADepartment of Medicine, University of Tennessee, 956 Court Avenue, Memphis, TN 38163, USAKaiser Permanente Northern California, Division of Research, 2000 Broadway, Oakland, CA 94612, USADepartment of Family Medicine and Public Health, University of California, 9500 Gilman Drive No. 0725, San Diego, La Jolla, CA 92093, USADepartment of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin, P.O. Box 245209, Drachman Hall A260, Tucson, AZ 85724, USAStudies suggest that ACE-inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) may preserve skeletal muscle with aging. We evaluated longitudinal differences in lean body mass (LBM) among women diagnosed with hypertension and classified as ACE-I/ARB users and nonusers among Women’s Health Initiative participants that received dual energy X-ray absorptiometry scans to estimate body composition (n=10,635) at baseline and at years 3 and 6 of follow-up. Of those, 2642 were treated for hypertension at baseline. Multivariate linear regression models, adjusted for relevant demographics, behaviors, and medications, assessed ACE-I/ARB use/nonuse and LBM associations at baseline, as well as change in LBM over 3 and 6 years. Although BMI did not differ by ACE-I/ARB use, LBM (%) was significantly higher in ACE-I/ARB users versus nonusers at baseline (52.2% versus 51.3%, resp., p=0.001). There was no association between ACE-I/ARB usage and change in LBM over time. Reasons for higher LBM with ACE-I/ARB use cross sectionally, but not longitundinally, are unclear and may reflect a threshold effect of these medications on LBM that is attenuated over time. Nevertheless, ACE-I/ARB use does not appear to negatively impact LBM in the long term.http://dx.doi.org/10.1155/2018/8491092 |
| spellingShingle | Jennifer W. Bea Sylvia Wassertheil-Smoller Betsy C. Wertheim Yann Klimentidis Zhao Chen Oleg Zaslavsky Todd M. Manini Catherine R. Womack Candyce H. Kroenke Andrea Z. LaCroix Cynthia A. Thomson Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women Journal of Aging Research |
| title | Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women |
| title_full | Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women |
| title_fullStr | Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women |
| title_full_unstemmed | Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women |
| title_short | Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women |
| title_sort | associations between ace inhibitors angiotensin receptor blockers and lean body mass in community dwelling older women |
| url | http://dx.doi.org/10.1155/2018/8491092 |
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