Circulating tumor DNA detection (liquid biopsy): prospects in oncology
Modern research techniques allows tumor studying in almost any level: protein expression, structural changes of DNA, RNA, epigenetic changes, activity of signaling pathways, microenvironment, interaction with the immune system, etc. However, tumor samples are obtained as 100 years ago – by tumor bio...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2015-01-01
|
| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/129 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849241183777193984 |
|---|---|
| author | N. V. Zhukov A. R. Zaretskiy S. A. Lukyanov S. A. Rumyantsev |
| author_facet | N. V. Zhukov A. R. Zaretskiy S. A. Lukyanov S. A. Rumyantsev |
| author_sort | N. V. Zhukov |
| collection | DOAJ |
| description | Modern research techniques allows tumor studying in almost any level: protein expression, structural changes of DNA, RNA, epigenetic changes, activity of signaling pathways, microenvironment, interaction with the immune system, etc. However, tumor samples are obtained as 100 years ago – by tumor biopsy prior to treatment. Based on available data about intratumoral heterogeneity and tumor changes during treatment, it may be one of the factors braking to obtain required information of tumor biology. According to study, the analysis of circulating tumor DNA (ctDNA) allows to hope to overcome the key limitations of routine biopsy. One of the key benefits of ctDNA analysis is the ability to a more comprehensive tumor investigation, while maintaining a high level of specificity, almost as well as a routine biopsy. Detection sensitivity of ctDNA continues to increase due to the development of new technology. The study of ctDNA may lead to breakthrough results in understanding of tumors molecular heterogeneity, development of resistance to anticancer therapy and ways to overcome it, screening and a number of other key areas of modern oncology. |
| format | Article |
| id | doaj-art-ae739a53a2114b028a506294a4eaf0e6 |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2015-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-ae739a53a2114b028a506294a4eaf0e62025-08-20T04:00:14ZrusABV-pressОнкогематология1818-83462413-40232015-01-0194283610.17650/1818-8346-2014-9-4-28-36144Circulating tumor DNA detection (liquid biopsy): prospects in oncologyN. V. Zhukov0A. R. Zaretskiy1S. A. Lukyanov2S. A. Rumyantsev3N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 1, Ostrovityanova st., Moscow, Russia, 117997 Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198 M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow; 16/10, Miklukho-Maklaya st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198 M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow; 16/10, Miklukho-Maklaya st., Moscow, Russia, 117198N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 1, Ostrovityanova st., Moscow, Russia, 117997 Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Modern research techniques allows tumor studying in almost any level: protein expression, structural changes of DNA, RNA, epigenetic changes, activity of signaling pathways, microenvironment, interaction with the immune system, etc. However, tumor samples are obtained as 100 years ago – by tumor biopsy prior to treatment. Based on available data about intratumoral heterogeneity and tumor changes during treatment, it may be one of the factors braking to obtain required information of tumor biology. According to study, the analysis of circulating tumor DNA (ctDNA) allows to hope to overcome the key limitations of routine biopsy. One of the key benefits of ctDNA analysis is the ability to a more comprehensive tumor investigation, while maintaining a high level of specificity, almost as well as a routine biopsy. Detection sensitivity of ctDNA continues to increase due to the development of new technology. The study of ctDNA may lead to breakthrough results in understanding of tumors molecular heterogeneity, development of resistance to anticancer therapy and ways to overcome it, screening and a number of other key areas of modern oncology.https://oncohematology.abvpress.ru/ongm/article/view/129circulating tumor dnaliquid biopsysequencingmethylationmalignant tumorsintratumoral heterogeneity |
| spellingShingle | N. V. Zhukov A. R. Zaretskiy S. A. Lukyanov S. A. Rumyantsev Circulating tumor DNA detection (liquid biopsy): prospects in oncology Онкогематология circulating tumor dna liquid biopsy sequencing methylation malignant tumors intratumoral heterogeneity |
| title | Circulating tumor DNA detection (liquid biopsy): prospects in oncology |
| title_full | Circulating tumor DNA detection (liquid biopsy): prospects in oncology |
| title_fullStr | Circulating tumor DNA detection (liquid biopsy): prospects in oncology |
| title_full_unstemmed | Circulating tumor DNA detection (liquid biopsy): prospects in oncology |
| title_short | Circulating tumor DNA detection (liquid biopsy): prospects in oncology |
| title_sort | circulating tumor dna detection liquid biopsy prospects in oncology |
| topic | circulating tumor dna liquid biopsy sequencing methylation malignant tumors intratumoral heterogeneity |
| url | https://oncohematology.abvpress.ru/ongm/article/view/129 |
| work_keys_str_mv | AT nvzhukov circulatingtumordnadetectionliquidbiopsyprospectsinoncology AT arzaretskiy circulatingtumordnadetectionliquidbiopsyprospectsinoncology AT salukyanov circulatingtumordnadetectionliquidbiopsyprospectsinoncology AT sarumyantsev circulatingtumordnadetectionliquidbiopsyprospectsinoncology |