Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes
The cardio-ankle vascular index (CAVI) is used to test vascular function and is an arterial stiffness marker and potential predictor of cardiovascular events. This study aimed to analyze the relation between objective indices of diabetic polyneuropathy (DPN) and the CAVI. One hundred sixty-six patie...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/2810914 |
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| _version_ | 1850159291430862848 |
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| author | Akihiko Ando Michiaki Miyamoto Kazuhiko Kotani Kenta Okada Shoichiro Nagasaka Shun Ishibashi |
| author_facet | Akihiko Ando Michiaki Miyamoto Kazuhiko Kotani Kenta Okada Shoichiro Nagasaka Shun Ishibashi |
| author_sort | Akihiko Ando |
| collection | DOAJ |
| description | The cardio-ankle vascular index (CAVI) is used to test vascular function and is an arterial stiffness marker and potential predictor of cardiovascular events. This study aimed to analyze the relation between objective indices of diabetic polyneuropathy (DPN) and the CAVI. One hundred sixty-six patients with type 2 diabetes mellitus were included in this study. We used nerve conduction studies (NCSs) and the coefficient of variation of the R-R interval to evaluate DPN. We estimated arteriosclerosis by the CAVI. Simple and multiple linear regression analyses were performed between neuropathy indices and the CAVI. In univariate analysis, the CAVI showed significant associations with sural sensory nerve conduction velocity and median F-wave conduction velocity. Multiple linear regression analysis for the CAVI showed that sural nerve conduction velocity and median F-wave conduction velocity were significant explanatory variables second only to age. In multiple linear regression analysis for sural nerve conduction velocity among neuropathy indices, the CAVI remained the most significant explanatory variable. In multiple linear regression analysis for median nerve F-wave conduction velocity among neuropathy indices, the CAVI remained the second most significant explanatory variable following HbA1c. These results suggest a close relationship between macroangiopathy and DPN. |
| format | Article |
| id | doaj-art-ae6d63ebf4e74653b0cdd92109a51299 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ae6d63ebf4e74653b0cdd92109a512992025-08-20T02:23:35ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/28109142810914Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 DiabetesAkihiko Ando0Michiaki Miyamoto1Kazuhiko Kotani2Kenta Okada3Shoichiro Nagasaka4Shun Ishibashi5Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Tochigi 329-0498, JapanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Tochigi 329-0498, JapanDivision of Community and Family Medicine, Centre for Community Medicine, Jichi Medical University, Tochigi 329-0498, JapanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Tochigi 329-0498, JapanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Tochigi 329-0498, JapanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Tochigi 329-0498, JapanThe cardio-ankle vascular index (CAVI) is used to test vascular function and is an arterial stiffness marker and potential predictor of cardiovascular events. This study aimed to analyze the relation between objective indices of diabetic polyneuropathy (DPN) and the CAVI. One hundred sixty-six patients with type 2 diabetes mellitus were included in this study. We used nerve conduction studies (NCSs) and the coefficient of variation of the R-R interval to evaluate DPN. We estimated arteriosclerosis by the CAVI. Simple and multiple linear regression analyses were performed between neuropathy indices and the CAVI. In univariate analysis, the CAVI showed significant associations with sural sensory nerve conduction velocity and median F-wave conduction velocity. Multiple linear regression analysis for the CAVI showed that sural nerve conduction velocity and median F-wave conduction velocity were significant explanatory variables second only to age. In multiple linear regression analysis for sural nerve conduction velocity among neuropathy indices, the CAVI remained the most significant explanatory variable. In multiple linear regression analysis for median nerve F-wave conduction velocity among neuropathy indices, the CAVI remained the second most significant explanatory variable following HbA1c. These results suggest a close relationship between macroangiopathy and DPN.http://dx.doi.org/10.1155/2017/2810914 |
| spellingShingle | Akihiko Ando Michiaki Miyamoto Kazuhiko Kotani Kenta Okada Shoichiro Nagasaka Shun Ishibashi Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes Journal of Diabetes Research |
| title | Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes |
| title_full | Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes |
| title_fullStr | Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes |
| title_full_unstemmed | Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes |
| title_short | Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes |
| title_sort | cardio ankle vascular index and indices of diabetic polyneuropathy in patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2017/2810914 |
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