Assisting significance of lncRNA ASB16-AS1 in the early detection and prognosis prediction of patients with deep venous thrombosis
Abstract Background Deep venous thrombosis (DVT) is a kind of vascular obstruction, that commonly and widely occurs in lower limbs. Due to the lack of obvious symptoms in the early stage, the rate of misdiagnosis and missed diagnosis is high. This study evaluated the expression and significance of l...
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BMC
2025-02-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04487-0 |
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| author | Menglan Li Yingying Li Dawei Zhang Cheng Cheng Meiying Yang Xiuyin Zhang Xinming Yu Bo Lu Min Wang |
| author_facet | Menglan Li Yingying Li Dawei Zhang Cheng Cheng Meiying Yang Xiuyin Zhang Xinming Yu Bo Lu Min Wang |
| author_sort | Menglan Li |
| collection | DOAJ |
| description | Abstract Background Deep venous thrombosis (DVT) is a kind of vascular obstruction, that commonly and widely occurs in lower limbs. Due to the lack of obvious symptoms in the early stage, the rate of misdiagnosis and missed diagnosis is high. This study evaluated the expression and significance of lncRNA ASB16-AS1 (ASB16-AS1) in DVT aiming to identify a novel biomarker for its screening and monitoring. Methods There were 77 DVT patients and 62 healthy individuals included in this study. Plasma ASB16-AS1 level was evaluated using PCR and compared between DVT and healthy groups. The diagnostic and prognostic values of ASB16-AS1 were assessed with ROC and Cox analyses. The correlation of ASB16-AS1 with patients’ conditions, inflammation, and oxidative stress was evaluated by Spearman correlation analysis. Results ASB16-AS1 was significantly upregulated in DVT (P < 0.001), which could discriminate DVT patients from healthy individuals with high sensitivity and specificity (AUC of ROC = 0.858). Increased ASB16-AS1 was associated with the incidence of complications (P = 0.033) and especially for pulmonary embolism in patients (P = 0.029). ASB16-AS1 was negatively correlated with prothrombin time (PT, r = -0.763), antithrombin level (AT, r = -0.711), and international normalized ratio (INR, r = -0.764), and showed positive correlation with fibrinogen (FIB, r = 0.793) and D-dimer (D-D, r = 0.731). Additionally, ASB16-AS1 was positively correlated with pro-inflammation cytokines (rIL−6 = 0.853, rIL−10 = -0.836, rhsCRP = 0.787) and pro-oxidative stress factors (rSOD = -0.751, rMDA = 0.842, r8-isoPGF 2α = 0.840). Conclusion Upregulated ASB16-AS1 was identified as a diagnostic and prognostic biomarker of DVT and was closely associated with inflammation and oxidative stress during DVT. |
| format | Article |
| id | doaj-art-ae6bfae47ba842e08bf0e11281ff6882 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-ae6bfae47ba842e08bf0e11281ff68822025-02-09T12:11:12ZengBMCBMC Cardiovascular Disorders1471-22612025-02-012511910.1186/s12872-025-04487-0Assisting significance of lncRNA ASB16-AS1 in the early detection and prognosis prediction of patients with deep venous thrombosisMenglan Li0Yingying Li1Dawei Zhang2Cheng Cheng3Meiying Yang4Xiuyin Zhang5Xinming Yu6Bo Lu7Min Wang8Heilongjiang University of Chinese MedicineCardiac and Vascular Surgical Monitoring, Jiangsu Province HospitalDepartment of Orthopedics, Zibo Central HospitalDepartment of Cardiovascular Medicine, Zibo Central HospitalDepartment of Orthopedics, Zibo Central HospitalDepartment of Burn Plastic Surgery, Zibo Central HospitalDepartment of Vascular Surgery, Zibo Central HospitalDepartment of Cardiology, Xi’an Central HospitalDepartment of Vascular Surgery, Zibo Central HospitalAbstract Background Deep venous thrombosis (DVT) is a kind of vascular obstruction, that commonly and widely occurs in lower limbs. Due to the lack of obvious symptoms in the early stage, the rate of misdiagnosis and missed diagnosis is high. This study evaluated the expression and significance of lncRNA ASB16-AS1 (ASB16-AS1) in DVT aiming to identify a novel biomarker for its screening and monitoring. Methods There were 77 DVT patients and 62 healthy individuals included in this study. Plasma ASB16-AS1 level was evaluated using PCR and compared between DVT and healthy groups. The diagnostic and prognostic values of ASB16-AS1 were assessed with ROC and Cox analyses. The correlation of ASB16-AS1 with patients’ conditions, inflammation, and oxidative stress was evaluated by Spearman correlation analysis. Results ASB16-AS1 was significantly upregulated in DVT (P < 0.001), which could discriminate DVT patients from healthy individuals with high sensitivity and specificity (AUC of ROC = 0.858). Increased ASB16-AS1 was associated with the incidence of complications (P = 0.033) and especially for pulmonary embolism in patients (P = 0.029). ASB16-AS1 was negatively correlated with prothrombin time (PT, r = -0.763), antithrombin level (AT, r = -0.711), and international normalized ratio (INR, r = -0.764), and showed positive correlation with fibrinogen (FIB, r = 0.793) and D-dimer (D-D, r = 0.731). Additionally, ASB16-AS1 was positively correlated with pro-inflammation cytokines (rIL−6 = 0.853, rIL−10 = -0.836, rhsCRP = 0.787) and pro-oxidative stress factors (rSOD = -0.751, rMDA = 0.842, r8-isoPGF 2α = 0.840). Conclusion Upregulated ASB16-AS1 was identified as a diagnostic and prognostic biomarker of DVT and was closely associated with inflammation and oxidative stress during DVT.https://doi.org/10.1186/s12872-025-04487-0DVTlncRNA ADB16-AS1Inflammatory responseOxidative stressOccurrenceDevelopment |
| spellingShingle | Menglan Li Yingying Li Dawei Zhang Cheng Cheng Meiying Yang Xiuyin Zhang Xinming Yu Bo Lu Min Wang Assisting significance of lncRNA ASB16-AS1 in the early detection and prognosis prediction of patients with deep venous thrombosis BMC Cardiovascular Disorders DVT lncRNA ADB16-AS1 Inflammatory response Oxidative stress Occurrence Development |
| title | Assisting significance of lncRNA ASB16-AS1 in the early detection and prognosis prediction of patients with deep venous thrombosis |
| title_full | Assisting significance of lncRNA ASB16-AS1 in the early detection and prognosis prediction of patients with deep venous thrombosis |
| title_fullStr | Assisting significance of lncRNA ASB16-AS1 in the early detection and prognosis prediction of patients with deep venous thrombosis |
| title_full_unstemmed | Assisting significance of lncRNA ASB16-AS1 in the early detection and prognosis prediction of patients with deep venous thrombosis |
| title_short | Assisting significance of lncRNA ASB16-AS1 in the early detection and prognosis prediction of patients with deep venous thrombosis |
| title_sort | assisting significance of lncrna asb16 as1 in the early detection and prognosis prediction of patients with deep venous thrombosis |
| topic | DVT lncRNA ADB16-AS1 Inflammatory response Oxidative stress Occurrence Development |
| url | https://doi.org/10.1186/s12872-025-04487-0 |
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