Molecular Insights: The Gut Microbiota's Impact on Colorectal Cancer
Globally, colorectal cancer (CRC) ranks second in terms of cancer-related fatalities. Several lines of evidence point to the gut microbiota's role in increasing inflammation and tumour growth, despite the fact that CRC is believed to be the result of a genetic-environmental interaction. A perso...
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| Format: | Article |
| Language: | English |
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An-Najah National University
2024-08-01
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| Series: | مجلة جامعة النجاح للأبحاث العلوم الطبيعية |
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| Online Access: | https://journals.najah.edu/media/journals/full_texts/8_BHvvIdu.pdf |
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| author | Samer Jarrar Ghaleb Adwan |
| author_facet | Samer Jarrar Ghaleb Adwan |
| author_sort | Samer Jarrar |
| collection | DOAJ |
| description | Globally, colorectal cancer (CRC) ranks second in terms of cancer-related fatalities. Several lines of evidence point to the gut microbiota's role in increasing inflammation and tumour growth, despite the fact that CRC is believed to be the result of a genetic-environmental interaction. A person's gut microbiota is made up of around 40 trillion bacteria. Next-generation sequencing technologies and metagenomics have advanced the understanding of the ecology of gut microbes and have contributed to the connection between gut microbiota and colorectal cancer. Numerous investigations conducted on both human and animal models have highlighted the part that specific gut bacterialike Fusobacterium nucleatum, Bacteroides fragilis with enterotoxigenic properties, and Escherichia coli play critical role in the development and progression of colorectal cancer (CRC). New directions for the use of gut microbiota in CRC diagnosis, prevention, and therapy have been made possible by metagenomic research. The contribution of gut microbiota to colorectal cancer development and its possible therapeutic uses are outlined in this review paper |
| format | Article |
| id | doaj-art-ae6b14e2c9f14e2a9bbbaebc037922d0 |
| institution | DOAJ |
| issn | 1727-2114 2311-8865 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | An-Najah National University |
| record_format | Article |
| series | مجلة جامعة النجاح للأبحاث العلوم الطبيعية |
| spelling | doaj-art-ae6b14e2c9f14e2a9bbbaebc037922d02025-08-20T03:23:35ZengAn-Najah National Universityمجلة جامعة النجاح للأبحاث العلوم الطبيعية1727-21142311-88652024-08-01391637210.35552/anujr.a.39.1.2275Molecular Insights: The Gut Microbiota's Impact on Colorectal CancerSamer Jarrar0Ghaleb Adwan1NoneDepartment of Biology and Biotechnology, Faculty of Sciences, An-Najah National University, Nablus, PalestineGlobally, colorectal cancer (CRC) ranks second in terms of cancer-related fatalities. Several lines of evidence point to the gut microbiota's role in increasing inflammation and tumour growth, despite the fact that CRC is believed to be the result of a genetic-environmental interaction. A person's gut microbiota is made up of around 40 trillion bacteria. Next-generation sequencing technologies and metagenomics have advanced the understanding of the ecology of gut microbes and have contributed to the connection between gut microbiota and colorectal cancer. Numerous investigations conducted on both human and animal models have highlighted the part that specific gut bacterialike Fusobacterium nucleatum, Bacteroides fragilis with enterotoxigenic properties, and Escherichia coli play critical role in the development and progression of colorectal cancer (CRC). New directions for the use of gut microbiota in CRC diagnosis, prevention, and therapy have been made possible by metagenomic research. The contribution of gut microbiota to colorectal cancer development and its possible therapeutic uses are outlined in this review paperhttps://journals.najah.edu/media/journals/full_texts/8_BHvvIdu.pdfgut microbiotabiomarkerscolorectal cancermolecular insights |
| spellingShingle | Samer Jarrar Ghaleb Adwan Molecular Insights: The Gut Microbiota's Impact on Colorectal Cancer مجلة جامعة النجاح للأبحاث العلوم الطبيعية gut microbiota biomarkers colorectal cancer molecular insights |
| title | Molecular Insights: The Gut Microbiota's Impact on Colorectal Cancer |
| title_full | Molecular Insights: The Gut Microbiota's Impact on Colorectal Cancer |
| title_fullStr | Molecular Insights: The Gut Microbiota's Impact on Colorectal Cancer |
| title_full_unstemmed | Molecular Insights: The Gut Microbiota's Impact on Colorectal Cancer |
| title_short | Molecular Insights: The Gut Microbiota's Impact on Colorectal Cancer |
| title_sort | molecular insights the gut microbiota s impact on colorectal cancer |
| topic | gut microbiota biomarkers colorectal cancer molecular insights |
| url | https://journals.najah.edu/media/journals/full_texts/8_BHvvIdu.pdf |
| work_keys_str_mv | AT samerjarrar molecularinsightsthegutmicrobiotasimpactoncolorectalcancer AT ghalebadwan molecularinsightsthegutmicrobiotasimpactoncolorectalcancer |