NEW INDICATORS OF HSP27 FUNCTIONAL STATE IN BREAST CANCER CELLS WITH DIFFERENT VARIANTS OF HER2/NEU-STATUS
New and original values (coefficient of phosphorylation and coefficient of intracellular distribution) proposed. They are reflecting a functional state of the heat shock protein 27 kDa (Hsp27) in tumor cells of breast cancer. These coefficients are more clearly reflect the functional state of Hsp27,...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/107 |
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| author | E. V. Kaigorodova M. V. Bogatyuk M. V. Zavyalova N. A. Tarabanovskaya E. I. Simolina E. M. Slonimskaya E. L. Choynzonov V. M. Perelmuter |
| author_facet | E. V. Kaigorodova M. V. Bogatyuk M. V. Zavyalova N. A. Tarabanovskaya E. I. Simolina E. M. Slonimskaya E. L. Choynzonov V. M. Perelmuter |
| author_sort | E. V. Kaigorodova |
| collection | DOAJ |
| description | New and original values (coefficient of phosphorylation and coefficient of intracellular distribution) proposed. They are reflecting a functional state of the heat shock protein 27 kDa (Hsp27) in tumor cells of breast cancer. These coefficients are more clearly reflect the functional state of Hsp27, than classical evaluation of chaperone expression only in the cytoplasm. It has been shown that in tumors with high expression of receptor Her2/neu on the membrane in the absence of gene amplification cerb2/neu (Her2/neu (3+) FISH (-)) there are low coefficients of phosphorylation and intracellular distribution as compared with Her2/neu-positive (Her2/neu (2+/3+) FISH (+)) and Her2/neu-negative tumors (Her2/neu (0/1+) FISH (-)). The possible molecular mechanisms of the phenomenon of dissonance cerb2 / neu gene amplification and receptor Her2/neu expression on the membrane of tumor cells breast cancer are discussing. |
| format | Article |
| id | doaj-art-ae6a3dfee50f4c53a9c05af71358f5de |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-ae6a3dfee50f4c53a9c05af71358f5de2025-08-20T02:59:11ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01113844107NEW INDICATORS OF HSP27 FUNCTIONAL STATE IN BREAST CANCER CELLS WITH DIFFERENT VARIANTS OF HER2/NEU-STATUSE. V. Kaigorodova0M. V. Bogatyuk1M. V. Zavyalova2N. A. Tarabanovskaya3E. I. Simolina4E. M. Slonimskaya5E. L. Choynzonov6V. M. Perelmuter7Tomsk Cancer Research Institute; Tomsk State University; Siberian State Medical University, TomskTomsk Cancer Research InstituteTomsk Cancer Research Institute; Tomsk State University; Siberian State Medical University, TomskTomsk Cancer Research InstituteTomsk Cancer Research InstituteTomsk Cancer Research Institute; Siberian State Medical University, TomskTomsk Cancer Research Institute; Siberian State Medical University, TomskTomsk Cancer Research Institute; Siberian State Medical University, TomskNew and original values (coefficient of phosphorylation and coefficient of intracellular distribution) proposed. They are reflecting a functional state of the heat shock protein 27 kDa (Hsp27) in tumor cells of breast cancer. These coefficients are more clearly reflect the functional state of Hsp27, than classical evaluation of chaperone expression only in the cytoplasm. It has been shown that in tumors with high expression of receptor Her2/neu on the membrane in the absence of gene amplification cerb2/neu (Her2/neu (3+) FISH (-)) there are low coefficients of phosphorylation and intracellular distribution as compared with Her2/neu-positive (Her2/neu (2+/3+) FISH (+)) and Her2/neu-negative tumors (Her2/neu (0/1+) FISH (-)). The possible molecular mechanisms of the phenomenon of dissonance cerb2 / neu gene amplification and receptor Her2/neu expression on the membrane of tumor cells breast cancer are discussing.https://www.siboncoj.ru/jour/article/view/107breast cancerihchsp27her2/neufishcerb2/neu |
| spellingShingle | E. V. Kaigorodova M. V. Bogatyuk M. V. Zavyalova N. A. Tarabanovskaya E. I. Simolina E. M. Slonimskaya E. L. Choynzonov V. M. Perelmuter NEW INDICATORS OF HSP27 FUNCTIONAL STATE IN BREAST CANCER CELLS WITH DIFFERENT VARIANTS OF HER2/NEU-STATUS Сибирский онкологический журнал breast cancer ihc hsp27 her2/neu fish cerb2/neu |
| title | NEW INDICATORS OF HSP27 FUNCTIONAL STATE IN BREAST CANCER CELLS WITH DIFFERENT VARIANTS OF HER2/NEU-STATUS |
| title_full | NEW INDICATORS OF HSP27 FUNCTIONAL STATE IN BREAST CANCER CELLS WITH DIFFERENT VARIANTS OF HER2/NEU-STATUS |
| title_fullStr | NEW INDICATORS OF HSP27 FUNCTIONAL STATE IN BREAST CANCER CELLS WITH DIFFERENT VARIANTS OF HER2/NEU-STATUS |
| title_full_unstemmed | NEW INDICATORS OF HSP27 FUNCTIONAL STATE IN BREAST CANCER CELLS WITH DIFFERENT VARIANTS OF HER2/NEU-STATUS |
| title_short | NEW INDICATORS OF HSP27 FUNCTIONAL STATE IN BREAST CANCER CELLS WITH DIFFERENT VARIANTS OF HER2/NEU-STATUS |
| title_sort | new indicators of hsp27 functional state in breast cancer cells with different variants of her2 neu status |
| topic | breast cancer ihc hsp27 her2/neu fish cerb2/neu |
| url | https://www.siboncoj.ru/jour/article/view/107 |
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