Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.
Pre-school age children account for 10%-20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the publis...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-03-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0000126 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849706048312573952 |
|---|---|
| author | Marco Albonico Henrietta Allen Lester Chitsulo Dirk Engels Albis-Francesco Gabrielli Lorenzo Savioli |
| author_facet | Marco Albonico Henrietta Allen Lester Chitsulo Dirk Engels Albis-Francesco Gabrielli Lorenzo Savioli |
| author_sort | Marco Albonico |
| collection | DOAJ |
| description | Pre-school age children account for 10%-20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the published literature and using information collated at World Health Organization headquarters, this paper summarizes the available evidence to support the recommendation that pre-school children should be included in regular deworming programmes. The first section describes the burden of STH disease in this age group, followed by a summary of how infection impacts iron status, growth, vitamin A status, and cognitive development and how STHs may exacerbate other high mortality infections. The second section explores the safety of the drugs themselves, given alone or co-administered, drug efficacy, and the importance of safe administration. The third section provides country-based evidence to demonstrate improved health outcomes after STH treatment. The final section provides country experiences in scaling up coverage of pre-school children by using other large scale public health interventions, including vitamin A programmes, immunization campaigns, and Child Health days. The paper concludes with a number of open research questions and a summary of some of the operational challenges that still need to be addressed. |
| format | Article |
| id | doaj-art-ae6994fee4e14f698b7b652ba7e0b085 |
| institution | DOAJ |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2008-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-ae6994fee4e14f698b7b652ba7e0b0852025-08-20T03:16:18ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352008-03-0123e12610.1371/journal.pntd.0000126Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.Marco AlbonicoHenrietta AllenLester ChitsuloDirk EngelsAlbis-Francesco GabrielliLorenzo SavioliPre-school age children account for 10%-20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the published literature and using information collated at World Health Organization headquarters, this paper summarizes the available evidence to support the recommendation that pre-school children should be included in regular deworming programmes. The first section describes the burden of STH disease in this age group, followed by a summary of how infection impacts iron status, growth, vitamin A status, and cognitive development and how STHs may exacerbate other high mortality infections. The second section explores the safety of the drugs themselves, given alone or co-administered, drug efficacy, and the importance of safe administration. The third section provides country-based evidence to demonstrate improved health outcomes after STH treatment. The final section provides country experiences in scaling up coverage of pre-school children by using other large scale public health interventions, including vitamin A programmes, immunization campaigns, and Child Health days. The paper concludes with a number of open research questions and a summary of some of the operational challenges that still need to be addressed.https://doi.org/10.1371/journal.pntd.0000126 |
| spellingShingle | Marco Albonico Henrietta Allen Lester Chitsulo Dirk Engels Albis-Francesco Gabrielli Lorenzo Savioli Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. PLoS Neglected Tropical Diseases |
| title | Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
| title_full | Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
| title_fullStr | Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
| title_full_unstemmed | Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
| title_short | Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
| title_sort | controlling soil transmitted helminthiasis in pre school age children through preventive chemotherapy |
| url | https://doi.org/10.1371/journal.pntd.0000126 |
| work_keys_str_mv | AT marcoalbonico controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT henriettaallen controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT lesterchitsulo controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT dirkengels controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT albisfrancescogabrielli controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT lorenzosavioli controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy |