The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients
Background. Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as m...
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Wiley
2020-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/3176521 |
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| author | Munir Garba Omar F. Khabour Karem H. Alzoubi Ahmed Abu-Siniyeh Firas Al-Qarqaz |
| author_facet | Munir Garba Omar F. Khabour Karem H. Alzoubi Ahmed Abu-Siniyeh Firas Al-Qarqaz |
| author_sort | Munir Garba |
| collection | DOAJ |
| description | Background. Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment. Aim. In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients (n = 230). Methods. Several biochemical parameters were measured at baseline and after treatments with isotretinoin. The ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients. Results. Alterations in lipid profile with a significant increase of ALT (P=0.007) were detected after isotretinoin treatment. Moreover, percentage change in HDL following isotretinoin treatment was significantly associated with rs1501299 (P=0.008). On the other hand, no associations between examined SNPs and side effects of isotretinoin and other lipid parameters (total cholesterol, LDL, and triglycerides) or liver function enzymes (ALT and AST) were detected. Conclusions. Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin. |
| format | Article |
| id | doaj-art-ae682599114749c8b08c54f8ea8819ce |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-ae682599114749c8b08c54f8ea8819ce2025-02-03T06:43:39ZengWileyDermatology Research and Practice1687-61051687-61132020-01-01202010.1155/2020/31765213176521The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne PatientsMunir Garba0Omar F. Khabour1Karem H. Alzoubi2Ahmed Abu-Siniyeh3Firas Al-Qarqaz4Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, JordanDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, JordanDepartment of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, JordanClinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Taif, Saudi ArabiaDepartment of Dermatology, Faculty of Medicine, Jordan University of Science, Technology, Irbid, JordanBackground. Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment. Aim. In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients (n = 230). Methods. Several biochemical parameters were measured at baseline and after treatments with isotretinoin. The ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients. Results. Alterations in lipid profile with a significant increase of ALT (P=0.007) were detected after isotretinoin treatment. Moreover, percentage change in HDL following isotretinoin treatment was significantly associated with rs1501299 (P=0.008). On the other hand, no associations between examined SNPs and side effects of isotretinoin and other lipid parameters (total cholesterol, LDL, and triglycerides) or liver function enzymes (ALT and AST) were detected. Conclusions. Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin.http://dx.doi.org/10.1155/2020/3176521 |
| spellingShingle | Munir Garba Omar F. Khabour Karem H. Alzoubi Ahmed Abu-Siniyeh Firas Al-Qarqaz The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients Dermatology Research and Practice |
| title | The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients |
| title_full | The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients |
| title_fullStr | The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients |
| title_full_unstemmed | The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients |
| title_short | The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients |
| title_sort | association between adiponectin single nucleotide polymorphisms and side effects of isotretinoin in acne patients |
| url | http://dx.doi.org/10.1155/2020/3176521 |
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