Elucidating stearoyl metabolism and NCOA4-mediated ferroptosis in gastric cancer liver metastasis through multi-omics single-cell integrative mendelian analysis: advancing personalized immunotherapy strategies

Elucidating stearoyl metabolism and NCOA4-mediated ferroptosis in gastric cancer liver metastasis through multi-omics single-cell integrative mendelian analysis: advancing personalized immunotherapy strategies

Abstract Background The metabolism of stearoyl-GPE plays a key role in the liver metastasis of gastric cancer. This investigation delves into the mechanisms underlying the intricate tumor microenvironment (TME) heterogeneity triggered by stearoyl metabolism in gastric cancer with liver metastasis (L...

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Main Authors: Zhongqiu Yang, Yuquan Chen, Yaping Miao, Haisheng Yan, Kexin Chen, Yaoqin Xu, Lanqian Su, Lanyue Zhang, Yalan Yan, Hao Chi, Jin Fu, Lexin Wang
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Oncology
Subjects:
LMGC
Ferroptosis
Stearoyl metabolism
NCOA4
Spatial transcriptomics
Single-cell RNA sequencing
Online Access:https://doi.org/10.1007/s12672-025-01769-z
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