Primary lymphoma arising in Paget’s disease in a patient with primary hyperparathyroidism
Background: Paget’s disease of bone (PDB) is characterized by a disturbance of the balance between bone formation and bone resorption at one or more bone sites. Its neoplastic transformation to osteosarcoma of the bone has been widely cited in the literature; however, association with non-Hodgkin’s...
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SMC MEDIA SRL
2025-01-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/4778 |
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| author | Mercedes De La Fuente Marina Arroyo Ana S. Collado Elena C. Gallardo Santiago Montes Jose M. Olmos |
| author_facet | Mercedes De La Fuente Marina Arroyo Ana S. Collado Elena C. Gallardo Santiago Montes Jose M. Olmos |
| author_sort | Mercedes De La Fuente |
| collection | DOAJ |
| description | Background: Paget’s disease of bone (PDB) is characterized by a disturbance of the balance between bone formation and bone resorption at one or more bone sites. Its neoplastic transformation to osteosarcoma of the bone has been widely cited in the literature; however, association with non-Hodgkin’s lymphoma (NHL) is very uncommon. In addition, whereas the pathophysiological relationship between PDB and secondary hyperparathyroidism is well established, there is much debate about the association between PDB and primary hyperparathyroidism (PHPT).
Case Report: We present a case of NHL arising in pagetoid bone in a 56-year-old man, who was subsequently diagnosed with primary hyperparathyroidism (PHPT).
Discussion: The malignant potential of pagetoid bone is well known, with sarcomatous degeneration being the most common neoplasm. Therefore, when pain recurred in our patient, 3 years after treatment of PDB, the presumptive diagnosis was a sarcomatous degeneration of the pagetoid bone. However, bone biopsy revealed a primary lymphoma, an extremely rare association that has been described only in a few cases. In addition, PHPT is rarely associated with PDB, although a link between PHPT and an increased risk of malignancy has been suggested.
Conclusion: To the best of our knowledge, this is the first case of these three different bone diseases in the same patient. Further studies are needed to understand the possible molecular basis of the association among these diseases. |
| format | Article |
| id | doaj-art-ae5d002cbab2416ca5e78040232e153b |
| institution | Kabale University |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-ae5d002cbab2416ca5e78040232e153b2025-02-04T13:37:20ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-01-0110.12890/2025_0047784313Primary lymphoma arising in Paget’s disease in a patient with primary hyperparathyroidismMercedes De La Fuente0Marina Arroyo1Ana S. Collado2Elena C. Gallardo3Santiago Montes4Jose M. Olmos5Division of Internal Medicine, Hospital Universitario Marqués de Valdecilla, Santander, SpainDivision of Radiology, Hospital Universitario Marqués de Valdecilla, Santander, SpainDivision of Pathology, Hospital Universitario Marqués de Valdecilla, Santander, SpainDivision of Radiology, Hospital Universitario Marqués de Valdecilla, Santander, SpainDivision of Pathology, Hospital Universitario Marqués de Valdecilla, Santander, Spain; Valdecilla Research Institute (IDIVAL), Santander, SpainDivision of Internal Medicine, Hospital Universitario Marqués de Valdecilla, Santander, Spain; Department of Medicine and Psychiatry, University of Cantabria, Santander, Spain; Valdecilla Research Institute (IDIVAL), Santander, SpainBackground: Paget’s disease of bone (PDB) is characterized by a disturbance of the balance between bone formation and bone resorption at one or more bone sites. Its neoplastic transformation to osteosarcoma of the bone has been widely cited in the literature; however, association with non-Hodgkin’s lymphoma (NHL) is very uncommon. In addition, whereas the pathophysiological relationship between PDB and secondary hyperparathyroidism is well established, there is much debate about the association between PDB and primary hyperparathyroidism (PHPT). Case Report: We present a case of NHL arising in pagetoid bone in a 56-year-old man, who was subsequently diagnosed with primary hyperparathyroidism (PHPT). Discussion: The malignant potential of pagetoid bone is well known, with sarcomatous degeneration being the most common neoplasm. Therefore, when pain recurred in our patient, 3 years after treatment of PDB, the presumptive diagnosis was a sarcomatous degeneration of the pagetoid bone. However, bone biopsy revealed a primary lymphoma, an extremely rare association that has been described only in a few cases. In addition, PHPT is rarely associated with PDB, although a link between PHPT and an increased risk of malignancy has been suggested. Conclusion: To the best of our knowledge, this is the first case of these three different bone diseases in the same patient. Further studies are needed to understand the possible molecular basis of the association among these diseases.https://www.ejcrim.com/index.php/EJCRIM/article/view/4778hyperparathyroidismpaget’s disease of bonelymphoma |
| spellingShingle | Mercedes De La Fuente Marina Arroyo Ana S. Collado Elena C. Gallardo Santiago Montes Jose M. Olmos Primary lymphoma arising in Paget’s disease in a patient with primary hyperparathyroidism European Journal of Case Reports in Internal Medicine hyperparathyroidism paget’s disease of bone lymphoma |
| title | Primary lymphoma arising in Paget’s disease in a patient with primary hyperparathyroidism |
| title_full | Primary lymphoma arising in Paget’s disease in a patient with primary hyperparathyroidism |
| title_fullStr | Primary lymphoma arising in Paget’s disease in a patient with primary hyperparathyroidism |
| title_full_unstemmed | Primary lymphoma arising in Paget’s disease in a patient with primary hyperparathyroidism |
| title_short | Primary lymphoma arising in Paget’s disease in a patient with primary hyperparathyroidism |
| title_sort | primary lymphoma arising in paget s disease in a patient with primary hyperparathyroidism |
| topic | hyperparathyroidism paget’s disease of bone lymphoma |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/4778 |
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