Memory T Cells, Recombinant Listeria monocytogenes, and Cancer Vaccines
Memory T cells are essential for effective and durable immune responses, as they provide long-term immunological surveillance and rapid reactivity upon re-exposure to a given pathogen or cancer cell. In solid tumors, the immunosuppressive tumor microenvironment (TME) often hinders immune activation,...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-07-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/7/10.31083/FBL36329 |
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| author | Abolaji Samson Olagunju Maribel Limachi Loza Marielly Câmara Rocha Gustavo P. Amarante-Mendes |
| author_facet | Abolaji Samson Olagunju Maribel Limachi Loza Marielly Câmara Rocha Gustavo P. Amarante-Mendes |
| author_sort | Abolaji Samson Olagunju |
| collection | DOAJ |
| description | Memory T cells are essential for effective and durable immune responses, as they provide long-term immunological surveillance and rapid reactivity upon re-exposure to a given pathogen or cancer cell. In solid tumors, the immunosuppressive tumor microenvironment (TME) often hinders immune activation, making enhancing memory T cell formation and persistence a key goal in cancer immunotherapy. Novel strategies are exploring ways to support these memory T cells, including using Listeria monocytogenes as a cancer vaccine vector. Notably, L. monocytogenes has unique properties that make it an ideal candidate for this purpose: it is highly effective at activating T cells, promoting the differentiation and survival of memory T cells, and modulating the TME to favor immune cell function. Thus, by leveraging the ability of L. monocytogenes to induce a strong, sustained T-cell response, researchers aim to develop vaccines that provide lasting immunity against tumors, reduce recurrence rates, and improve patient survival outcomes. This mini-review highlights the potential of memory T cell-focused cancer immunotherapy and the promising role of L. monocytogenes in advancing these efforts. |
| format | Article |
| id | doaj-art-ae5cf602d7ef4c0aac9194632d28a82c |
| institution | DOAJ |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-ae5cf602d7ef4c0aac9194632d28a82c2025-08-20T02:56:26ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-07-013073632910.31083/FBL36329S2768-6701(25)01669-7Memory T Cells, Recombinant Listeria monocytogenes, and Cancer VaccinesAbolaji Samson Olagunju0Maribel Limachi Loza1Marielly Câmara Rocha2Gustavo P. Amarante-Mendes3Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-000 São Paulo, BrazilDepartamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-000 São Paulo, BrazilDepartamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-000 São Paulo, BrazilDepartamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-000 São Paulo, BrazilMemory T cells are essential for effective and durable immune responses, as they provide long-term immunological surveillance and rapid reactivity upon re-exposure to a given pathogen or cancer cell. In solid tumors, the immunosuppressive tumor microenvironment (TME) often hinders immune activation, making enhancing memory T cell formation and persistence a key goal in cancer immunotherapy. Novel strategies are exploring ways to support these memory T cells, including using Listeria monocytogenes as a cancer vaccine vector. Notably, L. monocytogenes has unique properties that make it an ideal candidate for this purpose: it is highly effective at activating T cells, promoting the differentiation and survival of memory T cells, and modulating the TME to favor immune cell function. Thus, by leveraging the ability of L. monocytogenes to induce a strong, sustained T-cell response, researchers aim to develop vaccines that provide lasting immunity against tumors, reduce recurrence rates, and improve patient survival outcomes. This mini-review highlights the potential of memory T cell-focused cancer immunotherapy and the promising role of L. monocytogenes in advancing these efforts.https://www.imrpress.com/journal/FBL/30/7/10.31083/FBL36329memory t cellslisteria monocytogenescancer vaccinescd8+ t lymphocytes |
| spellingShingle | Abolaji Samson Olagunju Maribel Limachi Loza Marielly Câmara Rocha Gustavo P. Amarante-Mendes Memory T Cells, Recombinant Listeria monocytogenes, and Cancer Vaccines Frontiers in Bioscience-Landmark memory t cells listeria monocytogenes cancer vaccines cd8+ t lymphocytes |
| title | Memory T Cells, Recombinant Listeria monocytogenes, and Cancer Vaccines |
| title_full | Memory T Cells, Recombinant Listeria monocytogenes, and Cancer Vaccines |
| title_fullStr | Memory T Cells, Recombinant Listeria monocytogenes, and Cancer Vaccines |
| title_full_unstemmed | Memory T Cells, Recombinant Listeria monocytogenes, and Cancer Vaccines |
| title_short | Memory T Cells, Recombinant Listeria monocytogenes, and Cancer Vaccines |
| title_sort | memory t cells recombinant listeria monocytogenes and cancer vaccines |
| topic | memory t cells listeria monocytogenes cancer vaccines cd8+ t lymphocytes |
| url | https://www.imrpress.com/journal/FBL/30/7/10.31083/FBL36329 |
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