The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence
Osteoporosis is a chronic multifactorial condition that affects the skeletal system, leading to the deterioration of bone microstructure and an increased risk of bone fracture. Platelet-derived biomaterials (PDBs), so-called platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2023/9980349 |
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| author | Mohammad Amin Amiri Nima Farshidfar Richard J. Miron Arkadiusz Dziedzic Shahram Hamedani Sajad Daneshi Lobat Tayebi |
| author_facet | Mohammad Amin Amiri Nima Farshidfar Richard J. Miron Arkadiusz Dziedzic Shahram Hamedani Sajad Daneshi Lobat Tayebi |
| author_sort | Mohammad Amin Amiri |
| collection | DOAJ |
| description | Osteoporosis is a chronic multifactorial condition that affects the skeletal system, leading to the deterioration of bone microstructure and an increased risk of bone fracture. Platelet-derived biomaterials (PDBs), so-called platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have shown potential for improving bone healing by addressing microstructural impairment. While the administration of platelet concentrates has yielded positive results in bone regeneration, the optimal method for its administration in the clinical setting is still debatable. This comprehensive review aims to explore the systemic and local use of PRP/PRF for treating various bone defects and acute fractures in patients with osteoporosis. Furthermore, combining PRP/PRF with stem cells or osteoinductive and osteoconductive biomaterials has shown promise in restoring bone microstructural properties, treating bony defects, and improving implant osseointegration in osteoporotic animal models. Here, reviewing the results of in vitro and in vivo studies, this comprehensive evaluation provides a detailed mechanism for how platelet concentrates may support the healing process of osteoporotic bone fractures. |
| format | Article |
| id | doaj-art-ae5bf3da728b47cca19e2b189be99760 |
| institution | Kabale University |
| issn | 1687-8795 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-ae5bf3da728b47cca19e2b189be997602025-02-03T06:47:29ZengWileyInternational Journal of Biomaterials1687-87952023-01-01202310.1155/2023/9980349The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current EvidenceMohammad Amin Amiri0Nima Farshidfar1Richard J. Miron2Arkadiusz Dziedzic3Shahram Hamedani4Sajad Daneshi5Lobat Tayebi6Student Research CommitteeStem Cells Technology Research CenterDepartment of PeriodontologyDepartment of Conservative Dentistry with EndodonticsOral and Dental Disease Research CenterStem Cells Technology Research CenterMarquette University School of DentistryOsteoporosis is a chronic multifactorial condition that affects the skeletal system, leading to the deterioration of bone microstructure and an increased risk of bone fracture. Platelet-derived biomaterials (PDBs), so-called platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have shown potential for improving bone healing by addressing microstructural impairment. While the administration of platelet concentrates has yielded positive results in bone regeneration, the optimal method for its administration in the clinical setting is still debatable. This comprehensive review aims to explore the systemic and local use of PRP/PRF for treating various bone defects and acute fractures in patients with osteoporosis. Furthermore, combining PRP/PRF with stem cells or osteoinductive and osteoconductive biomaterials has shown promise in restoring bone microstructural properties, treating bony defects, and improving implant osseointegration in osteoporotic animal models. Here, reviewing the results of in vitro and in vivo studies, this comprehensive evaluation provides a detailed mechanism for how platelet concentrates may support the healing process of osteoporotic bone fractures.http://dx.doi.org/10.1155/2023/9980349 |
| spellingShingle | Mohammad Amin Amiri Nima Farshidfar Richard J. Miron Arkadiusz Dziedzic Shahram Hamedani Sajad Daneshi Lobat Tayebi The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence International Journal of Biomaterials |
| title | The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence |
| title_full | The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence |
| title_fullStr | The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence |
| title_full_unstemmed | The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence |
| title_short | The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence |
| title_sort | potential therapeutic effects of platelet derived biomaterials on osteoporosis a comprehensive review of current evidence |
| url | http://dx.doi.org/10.1155/2023/9980349 |
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