Vitamin D Decreases Susceptibility of CD4<sup>+</sup> T Cells to HIV Infection by Reducing AKT Phosphorylation and Glucose Uptake: A Bioinformatic and In Vitro Approach

Vitamin D Decreases Susceptibility of CD4<sup>+</sup> T Cells to HIV Infection by Reducing AKT Phosphorylation and Glucose Uptake: A Bioinformatic and In Vitro Approach

Activated immune cells are highly susceptible to human immunodeficiency virus (HIV) infection. Vitamin D (VitD) induces antimicrobial responses and reduces cellular activation. We investigated VitD effects on HIV-1 replication, glucose uptake, and gene regulation using computational and in vitro app...

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Bibliographic Details
Main Authors: John D. Loaiza, Jose Fernando Gómez, Daniel Muñoz-Escudero, Sandra M. Gonzalez, Timothy Kyle Eubank, Maria T. Rugeles, Ana Lucía Rodríguez-Perea, Wbeimar Aguilar-Jimenez
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomolecules
Subjects:
HIV
vitamin D
glucose uptake
Boolean modeling
protein kinase B
AKT signaling
Online Access:https://www.mdpi.com/2218-273X/15/3/432
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