Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of <i>Inonotus obliquus</i> Polysaccharide in the Treatment of Rheumatoid Arthritis

Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of <i>Inonotus obliquus</i> Polysaccharide in the Treatment of Rheumatoid Arthritis

<b>Background/Objectives:</b> Rheumatoid arthritis (RA) is a chronic, systemic, and progressive autoimmune–inflammatory disease primarily affecting small joints. <i>Inonotus obliquus</i> polysaccharide (IOP) is the main component of the parasitic fungus obliquus, which has an...

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Bibliographic Details
Main Authors: Yuan Fu, Tianyi Jiang, Xizhu Fang, Yifang Chen, Jiawei Li, Shengnan Huang, Fangfang Li, Dan Jin
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
<i>Inonotus obliquus</i> polysaccharide
rheumatoid arthritis
network pharmacology
NF-κB pathway
NLRP3 inflammasome
Online Access:https://www.mdpi.com/1424-8247/18/7/1017
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