Short-term effects of air pollution on the infectious disease spectrum in Shanghai, China: a time-series analysis from 2013 to 2019
BackgroundEpidemiological evidence on the effects of air pollution on infectious diseases remains inconsistent, highlighting the need for further research and analysis. We aimed to investigate the relationship between exposure to fine particulate matter (PM2.5) and ozone (O3) and the risk of nationa...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1454809/full |
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| author | Yihan Lin Hao Meng Yong He Wenzhuo Liang Yiran Niu Zhenliang Liu Ziying Wang Yangyang Tian Shiyang Chang |
| author_facet | Yihan Lin Hao Meng Yong He Wenzhuo Liang Yiran Niu Zhenliang Liu Ziying Wang Yangyang Tian Shiyang Chang |
| author_sort | Yihan Lin |
| collection | DOAJ |
| description | BackgroundEpidemiological evidence on the effects of air pollution on infectious diseases remains inconsistent, highlighting the need for further research and analysis. We aimed to investigate the relationship between exposure to fine particulate matter (PM2.5) and ozone (O3) and the risk of national notifiable infectious diseases in Shanghai, a megacity in China.MethodsA double-pollutant model was used for each air pollutant, utilizing time-series analysis to separately apply single and distributed lag models (DLMs) to assess the exposure-lag-response relationship for 43 national notifiable infectious diseases (NNIDs) from 2013 to 2019. The model was adjusted for seasonality, long-term trends, mean temperature, relative humidity, and other air pollutants. Analysis was further conducted for seven NNID categories (vaccine-preventable; bacterial; gastrointestinal and enterovirus; sexually transmitted and bloodborne; vector-borne; zoonotic; and quarantinable diseases) as well as specific diseases.ResultsThe study included 661,267 NNID cases and found that PM2.5 and O3 exposures were associated with increased NNID risks, although not within the same categories. A 10 μg/m3 increase in O3 was associated with a higher risk of total NNIDs (relative risk [RR] at lag 1 month: 1.29, 95% confidence interval [CI]: 1.02–1.65), vaccine-preventable diseases (RR at lag 1 month: 1.75, 95% CI: 1.02–3.01), and sexually transmitted and bloodborne diseases (RR at lag 2 month: 1.12, 95% CI: 1.00–1.26). However, the association with PM2.5 remained inconclusive.ConclusionThese findings suggest a potential link between ambient air pollution exposure and the risk of infectious diseases, highlighting the urgent need for a comprehensive understanding of the relationship between air pollution and notifiable infectious diseases, as well as an in-depth evaluation of disparities across the disease spectrum. |
| format | Article |
| id | doaj-art-ae4d2a9b3b60401d86d114d7aad39e40 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-ae4d2a9b3b60401d86d114d7aad39e402025-01-31T06:40:00ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011310.3389/fpubh.2025.14548091454809Short-term effects of air pollution on the infectious disease spectrum in Shanghai, China: a time-series analysis from 2013 to 2019Yihan Lin0Hao Meng1Yong He2Wenzhuo Liang3Yiran Niu4Zhenliang Liu5Ziying Wang6Yangyang Tian7Shiyang Chang8Department of Histology and Embryology, College of Basic Medical, Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathogenic Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathogenic Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang, ChinaDepartment of Histology and Embryology, College of Basic Medical, Hebei Medical University, Shijiazhuang, ChinaDepartment of Histology and Embryology, College of Basic Medical, Hebei Medical University, Shijiazhuang, ChinaDepartment of Histology and Embryology, College of Basic Medical, Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathogenic Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang, ChinaDepartment of Histology and Embryology, College of Basic Medical, Hebei Medical University, Shijiazhuang, ChinaDepartment of Histology and Embryology, College of Basic Medical, Hebei Medical University, Shijiazhuang, ChinaBackgroundEpidemiological evidence on the effects of air pollution on infectious diseases remains inconsistent, highlighting the need for further research and analysis. We aimed to investigate the relationship between exposure to fine particulate matter (PM2.5) and ozone (O3) and the risk of national notifiable infectious diseases in Shanghai, a megacity in China.MethodsA double-pollutant model was used for each air pollutant, utilizing time-series analysis to separately apply single and distributed lag models (DLMs) to assess the exposure-lag-response relationship for 43 national notifiable infectious diseases (NNIDs) from 2013 to 2019. The model was adjusted for seasonality, long-term trends, mean temperature, relative humidity, and other air pollutants. Analysis was further conducted for seven NNID categories (vaccine-preventable; bacterial; gastrointestinal and enterovirus; sexually transmitted and bloodborne; vector-borne; zoonotic; and quarantinable diseases) as well as specific diseases.ResultsThe study included 661,267 NNID cases and found that PM2.5 and O3 exposures were associated with increased NNID risks, although not within the same categories. A 10 μg/m3 increase in O3 was associated with a higher risk of total NNIDs (relative risk [RR] at lag 1 month: 1.29, 95% confidence interval [CI]: 1.02–1.65), vaccine-preventable diseases (RR at lag 1 month: 1.75, 95% CI: 1.02–3.01), and sexually transmitted and bloodborne diseases (RR at lag 2 month: 1.12, 95% CI: 1.00–1.26). However, the association with PM2.5 remained inconclusive.ConclusionThese findings suggest a potential link between ambient air pollution exposure and the risk of infectious diseases, highlighting the urgent need for a comprehensive understanding of the relationship between air pollution and notifiable infectious diseases, as well as an in-depth evaluation of disparities across the disease spectrum.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1454809/fullinfectious diseasesair pollutionfine particulate matterozonetime-series studydistributed lag model |
| spellingShingle | Yihan Lin Hao Meng Yong He Wenzhuo Liang Yiran Niu Zhenliang Liu Ziying Wang Yangyang Tian Shiyang Chang Short-term effects of air pollution on the infectious disease spectrum in Shanghai, China: a time-series analysis from 2013 to 2019 Frontiers in Public Health infectious diseases air pollution fine particulate matter ozone time-series study distributed lag model |
| title | Short-term effects of air pollution on the infectious disease spectrum in Shanghai, China: a time-series analysis from 2013 to 2019 |
| title_full | Short-term effects of air pollution on the infectious disease spectrum in Shanghai, China: a time-series analysis from 2013 to 2019 |
| title_fullStr | Short-term effects of air pollution on the infectious disease spectrum in Shanghai, China: a time-series analysis from 2013 to 2019 |
| title_full_unstemmed | Short-term effects of air pollution on the infectious disease spectrum in Shanghai, China: a time-series analysis from 2013 to 2019 |
| title_short | Short-term effects of air pollution on the infectious disease spectrum in Shanghai, China: a time-series analysis from 2013 to 2019 |
| title_sort | short term effects of air pollution on the infectious disease spectrum in shanghai china a time series analysis from 2013 to 2019 |
| topic | infectious diseases air pollution fine particulate matter ozone time-series study distributed lag model |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1454809/full |
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