The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled Trial
BackgroundIn recent years, the prevalence of cardiometabolic disease (CMD) in African American women has risen; the risk also increases with age, in comparison to men. Evidence demonstrates that stressful life events, including experiences of racism and perceived discriminati...
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JMIR Publications
2025-04-01
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| Series: | JMIR Research Protocols |
| Online Access: | https://www.researchprotocols.org/2025/1/e65649 |
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| author | Karen L Saban Cara Joyce Alexandria Nyembwe Linda Janusek Dina Tell Paula de la Pena Darnell Motley Lamise Shawahin Laura Prescott Stephanie Potts-Thompson Jacquelyn Y Taylor |
| author_facet | Karen L Saban Cara Joyce Alexandria Nyembwe Linda Janusek Dina Tell Paula de la Pena Darnell Motley Lamise Shawahin Laura Prescott Stephanie Potts-Thompson Jacquelyn Y Taylor |
| author_sort | Karen L Saban |
| collection | DOAJ |
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BackgroundIn recent years, the prevalence of cardiometabolic disease (CMD) in African American women has risen; the risk also increases with age, in comparison to men. Evidence demonstrates that stressful life events, including experiences of racism and perceived discrimination, contribute substantially to inflammatory diseases, such as CMD. Despite this evidence, few evidence-based interventions are available to assist individuals from minoritized communities in coping with the chronic stress related to their racial or ethnic identity.
ObjectiveOur proposed randomized controlled trial will test a novel, race-based intervention tailored to African American women, called Resilience, Stress, and Ethnicity (RiSE).
MethodsIn this randomized controlled trial, we will randomize participants 1:1 to the 8-week, group-based RiSE program (intervention) or a health education program (active control group). Both programs will consist of synchronous classes on Zoom and will be led by experts. The primary end point will be stress at 6 months after the intervention, and the efficacy of RiSE will be evaluated for improving stress-related symptoms (current perceived stress, depressive symptoms, fatigue, and sleep disturbance), improving coping strategies, and reducing inflammatory burden in African American women at risk for CMD. Validated survey measures and inflammatory biomarkers will be assessed at baseline, midintervention, intervention completion, and 6 months after the intervention, and differences over time by intervention will be evaluated using mixed effects models.
ResultsThis study was funded by the National Institute on Aging on March 30, 2023, with recruitment and enrollment beginning in October 2023. The study is underway, with 120 participants enrolled as of March 2025.
ConclusionsThis study will be one of the first to examine a race-based stress reduction intervention in African American women and has the potential to improve the health of minoritized groups faced with chronic stress associated with experiencing racism and discrimination. We anticipate that RiSE will reduce stress-related symptoms, enhance adaptive coping, and reduce inflammation.
Trial RegistrationClinicalTrials.gov NCT05902741; https://www.clinicaltrials.gov/study/NCT05902741 |
| format | Article |
| id | doaj-art-ae4b2586e7344fc2846f767ca5cf492a |
| institution | OA Journals |
| issn | 1929-0748 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | JMIR Publications |
| record_format | Article |
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| spelling | doaj-art-ae4b2586e7344fc2846f767ca5cf492a2025-08-20T02:27:57ZengJMIR PublicationsJMIR Research Protocols1929-07482025-04-0114e6564910.2196/65649The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled TrialKaren L Sabanhttps://orcid.org/0000-0001-5767-5453Cara Joycehttps://orcid.org/0000-0003-0468-8271Alexandria Nyembwehttps://orcid.org/0000-0002-6302-0899Linda Janusekhttps://orcid.org/0000-0003-2673-2296Dina Tellhttps://orcid.org/0000-0002-8141-7187Paula de la Penahttps://orcid.org/0000-0001-9083-0136Darnell Motleyhttps://orcid.org/0000-0002-3250-8154Lamise Shawahinhttps://orcid.org/0000-0003-0341-7111Laura Prescotthttps://orcid.org/0009-0001-6669-3482Stephanie Potts-Thompsonhttps://orcid.org/0000-0003-3484-0852Jacquelyn Y Taylorhttps://orcid.org/0000-0002-0858-7358 BackgroundIn recent years, the prevalence of cardiometabolic disease (CMD) in African American women has risen; the risk also increases with age, in comparison to men. Evidence demonstrates that stressful life events, including experiences of racism and perceived discrimination, contribute substantially to inflammatory diseases, such as CMD. Despite this evidence, few evidence-based interventions are available to assist individuals from minoritized communities in coping with the chronic stress related to their racial or ethnic identity. ObjectiveOur proposed randomized controlled trial will test a novel, race-based intervention tailored to African American women, called Resilience, Stress, and Ethnicity (RiSE). MethodsIn this randomized controlled trial, we will randomize participants 1:1 to the 8-week, group-based RiSE program (intervention) or a health education program (active control group). Both programs will consist of synchronous classes on Zoom and will be led by experts. The primary end point will be stress at 6 months after the intervention, and the efficacy of RiSE will be evaluated for improving stress-related symptoms (current perceived stress, depressive symptoms, fatigue, and sleep disturbance), improving coping strategies, and reducing inflammatory burden in African American women at risk for CMD. Validated survey measures and inflammatory biomarkers will be assessed at baseline, midintervention, intervention completion, and 6 months after the intervention, and differences over time by intervention will be evaluated using mixed effects models. ResultsThis study was funded by the National Institute on Aging on March 30, 2023, with recruitment and enrollment beginning in October 2023. The study is underway, with 120 participants enrolled as of March 2025. ConclusionsThis study will be one of the first to examine a race-based stress reduction intervention in African American women and has the potential to improve the health of minoritized groups faced with chronic stress associated with experiencing racism and discrimination. We anticipate that RiSE will reduce stress-related symptoms, enhance adaptive coping, and reduce inflammation. Trial RegistrationClinicalTrials.gov NCT05902741; https://www.clinicaltrials.gov/study/NCT05902741https://www.researchprotocols.org/2025/1/e65649 |
| spellingShingle | Karen L Saban Cara Joyce Alexandria Nyembwe Linda Janusek Dina Tell Paula de la Pena Darnell Motley Lamise Shawahin Laura Prescott Stephanie Potts-Thompson Jacquelyn Y Taylor The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled Trial JMIR Research Protocols |
| title | The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled Trial |
| title_full | The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled Trial |
| title_fullStr | The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled Trial |
| title_full_unstemmed | The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled Trial |
| title_short | The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled Trial |
| title_sort | effectiveness of a race based stress reduction intervention on improving stress related symptoms and inflammation in african american women at risk for cardiometabolic disease protocol for recruitment and intervention for a randomized controlled trial |
| url | https://www.researchprotocols.org/2025/1/e65649 |
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