Optimization of electrode position in electric field treatment for pancreatic cancer
Abstract Background In electric field-based cancer treatment, the intensity of the electric field applied to the tumor depends on the position of the electrode array, directly affecting the efficacy of treatment. The present study evaluated the effects of changing the position of the electrode array...
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BMC
2025-04-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03807-0 |
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| author | Sangcheol Kim Yousun Ko Dongho Shin Haksoo Kim Sung Uk Lee Jonghyun Kim Tae Hyun Kim Myonggeun Yoon |
| author_facet | Sangcheol Kim Yousun Ko Dongho Shin Haksoo Kim Sung Uk Lee Jonghyun Kim Tae Hyun Kim Myonggeun Yoon |
| author_sort | Sangcheol Kim |
| collection | DOAJ |
| description | Abstract Background In electric field-based cancer treatment, the intensity of the electric field applied to the tumor depends on the position of the electrode array, directly affecting the efficacy of treatment. The present study evaluated the effects of changing the position of the electrode array on the efficacy of electric field treatment for pancreatic cancer. Methods A 3D model was created based on computed tomography images of 13 pancreatic cancer patients. An electrode array was placed on the surface of the model at various positions, and the electric field was calculated for each. Six treatment plans were created for each patient by rotating each electrode array ± 15⁰, ± 30⁰ in the axial plane, and ± 10⁰ in the sagittal plane relative to the reference plan. The frequency was set at 150 kHz and the current density at 31 mArms/cm2 for calculation of all treatment plans. The mean electric field, minimum electric field, homogeneity index (HI) and coverage index (CI) calculated from the six simulated plans were compared with the reference plan to evaluate the effects of each simulated plan on the tumor. Results Comparisons of the simulated plans for each patient with the reference plan showed differences of -2.61 ∼ 11.31% in the mean electric field, -7.03 ∼ 13.87% in the minimum electric field, -64.14 ∼ 13.12% in the HI, and − 24.23 ∼ 11.00% in the CI. Compared with the reference plan, the optimal plans created by changing the electrode position improved the mean electric field 7.41%, the minimum electric field 7.20%, the HI 4.57%, and the CI 8.46%. Conclusions Use of a treatment planning system to determine the optimal placement of the electrode array based on the anatomical characteristics of each patient can improve the intensity of the electric field applied to the tumor. |
| format | Article |
| id | doaj-art-ae44271cf83d4b3f8c172483e3901c68 |
| institution | DOAJ |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-ae44271cf83d4b3f8c172483e3901c682025-08-20T03:04:50ZengBMCBMC Gastroenterology1471-230X2025-04-0125111110.1186/s12876-025-03807-0Optimization of electrode position in electric field treatment for pancreatic cancerSangcheol Kim0Yousun Ko1Dongho Shin2Haksoo Kim3Sung Uk Lee4Jonghyun Kim5Tae Hyun Kim6Myonggeun Yoon7Department of Biomedical Engineering, Korea UniversityDepartment of Biomedical Engineering, Korea UniversityProton Therapy Center, National Cancer CenterProton Therapy Center, National Cancer CenterProton Therapy Center, National Cancer CenterFieldCure Ltd.Proton Therapy Center, National Cancer CenterDepartment of Biomedical Engineering, Korea UniversityAbstract Background In electric field-based cancer treatment, the intensity of the electric field applied to the tumor depends on the position of the electrode array, directly affecting the efficacy of treatment. The present study evaluated the effects of changing the position of the electrode array on the efficacy of electric field treatment for pancreatic cancer. Methods A 3D model was created based on computed tomography images of 13 pancreatic cancer patients. An electrode array was placed on the surface of the model at various positions, and the electric field was calculated for each. Six treatment plans were created for each patient by rotating each electrode array ± 15⁰, ± 30⁰ in the axial plane, and ± 10⁰ in the sagittal plane relative to the reference plan. The frequency was set at 150 kHz and the current density at 31 mArms/cm2 for calculation of all treatment plans. The mean electric field, minimum electric field, homogeneity index (HI) and coverage index (CI) calculated from the six simulated plans were compared with the reference plan to evaluate the effects of each simulated plan on the tumor. Results Comparisons of the simulated plans for each patient with the reference plan showed differences of -2.61 ∼ 11.31% in the mean electric field, -7.03 ∼ 13.87% in the minimum electric field, -64.14 ∼ 13.12% in the HI, and − 24.23 ∼ 11.00% in the CI. Compared with the reference plan, the optimal plans created by changing the electrode position improved the mean electric field 7.41%, the minimum electric field 7.20%, the HI 4.57%, and the CI 8.46%. Conclusions Use of a treatment planning system to determine the optimal placement of the electrode array based on the anatomical characteristics of each patient can improve the intensity of the electric field applied to the tumor.https://doi.org/10.1186/s12876-025-03807-0Electric field treatmentTreatment planElectrode arrayPancreatic cancer |
| spellingShingle | Sangcheol Kim Yousun Ko Dongho Shin Haksoo Kim Sung Uk Lee Jonghyun Kim Tae Hyun Kim Myonggeun Yoon Optimization of electrode position in electric field treatment for pancreatic cancer BMC Gastroenterology Electric field treatment Treatment plan Electrode array Pancreatic cancer |
| title | Optimization of electrode position in electric field treatment for pancreatic cancer |
| title_full | Optimization of electrode position in electric field treatment for pancreatic cancer |
| title_fullStr | Optimization of electrode position in electric field treatment for pancreatic cancer |
| title_full_unstemmed | Optimization of electrode position in electric field treatment for pancreatic cancer |
| title_short | Optimization of electrode position in electric field treatment for pancreatic cancer |
| title_sort | optimization of electrode position in electric field treatment for pancreatic cancer |
| topic | Electric field treatment Treatment plan Electrode array Pancreatic cancer |
| url | https://doi.org/10.1186/s12876-025-03807-0 |
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