Correlation of structure and function in glaucoma
Objective: This study assessed the relationship of two structural tests, optic-disc photography and optical coherence tomography (OCT), and a functional test, standard achromatic perimetry (SAP), in the diagnosis of glaucoma. Methods: A retrospective review of charts from the database of a privat...
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Philippine Academy of Ophthalmology
2009-06-01
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| Series: | Philippine Journal of Ophthalmology |
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| Online Access: | https://paojournal.com/index.php/pjo/article/view/319 |
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| author | Maria Joanna Rodriguez-Chan, MD Patricia M. Khu,MD,MS Ma. Margarita L. Luna, MD Manuel B. Agulto, MD |
| author_facet | Maria Joanna Rodriguez-Chan, MD Patricia M. Khu,MD,MS Ma. Margarita L. Luna, MD Manuel B. Agulto, MD |
| author_sort | Maria Joanna Rodriguez-Chan, MD |
| collection | DOAJ |
| description | Objective: This study assessed the relationship of two structural tests, optic-disc photography and optical coherence tomography (OCT), and a functional test, standard achromatic perimetry (SAP), in the diagnosis of glaucoma.
Methods: A retrospective review of charts from the database of a private glaucoma specialist and the glaucoma clinic of a tertiary hospital was done. The participants were longitudinally evaluated and had comprehensive eye examination, imaging, and functional testing. Optic-disc photographs, OCTs, and SAPs were interpreted and evaluated separately, and then correlated with each other by two glaucoma experts working individually. Sensitivities, specificities, and predictive values were obtained for each diagnostic test and in combination. Kappa statistics were used for interobserver agreement.
Results: Three hundred sixty-seven eyes of 188 patients were included in the study. Fifty-eight patients were diagnosed as normal, 130 had glaucoma. OCT had the highest sensitivity and specificity at 70.7% and 76.6%, followed by SAP at 72.4% and 53.5% respectively. Optic-disc photos had the lowest sensitivity and specificity at 55.8% and 54.4% respectively, and the lowest interobserver agreement (kappa = 0.50-0.61). The predictive values of the 3 tests increased to 82% with good interobserver agreement (kappa = 0.68-0.78) when correlated with each other.
Conclusion: The correlation of structural and functional tests increased the accuracy of diagnosing glaucoma. These examinations offered complementary information and, when used in conjunction with comprehensive clinical evaluation, guided the clinician in the proper management of patients with glaucoma. |
| format | Article |
| id | doaj-art-ae3d8f9549e445548767c1bdf8bfd185 |
| institution | Kabale University |
| issn | 0031-7659 |
| language | English |
| publishDate | 2009-06-01 |
| publisher | Philippine Academy of Ophthalmology |
| record_format | Article |
| series | Philippine Journal of Ophthalmology |
| spelling | doaj-art-ae3d8f9549e445548767c1bdf8bfd1852025-08-20T03:40:22ZengPhilippine Academy of OphthalmologyPhilippine Journal of Ophthalmology0031-76592009-06-013411518319Correlation of structure and function in glaucomaMaria Joanna Rodriguez-Chan, MD0Patricia M. Khu,MD,MS1Ma. Margarita L. Luna, MD2Manuel B. Agulto, MD3Department of Ophthalmology and Visual Sciences University of the Philippines–Philippine General Hospital Manila, PhilippinesDepartment of Ophthalmology and Visual Sciences University of the Philippines–Philippine General Hospital Manila, Philippines; Institute of Ophthalmology National Institutes of Health University of the Philippines Manila Manila, Philippines; Eye Referral Center Manila, PhilippinesDepartment of Ophthalmology and Visual Sciences University of the Philippines–Philippine General Hospital Manila, Philippines; International Eye Institute St. Luke’s Medical Center Quezon City, PhilippinesDepartment of Ophthalmology and Visual Sciences University of the Philippines–Philippine General Hospital Manila, Philippines; Institute of Ophthalmology National Institutes of Health University of the Philippines Manila Manila, Philippines; Department of Ophthalmology Manila Doctors Hospital Manila, Philippines; Eye Referral Center Manila, PhilippinesObjective: This study assessed the relationship of two structural tests, optic-disc photography and optical coherence tomography (OCT), and a functional test, standard achromatic perimetry (SAP), in the diagnosis of glaucoma. Methods: A retrospective review of charts from the database of a private glaucoma specialist and the glaucoma clinic of a tertiary hospital was done. The participants were longitudinally evaluated and had comprehensive eye examination, imaging, and functional testing. Optic-disc photographs, OCTs, and SAPs were interpreted and evaluated separately, and then correlated with each other by two glaucoma experts working individually. Sensitivities, specificities, and predictive values were obtained for each diagnostic test and in combination. Kappa statistics were used for interobserver agreement. Results: Three hundred sixty-seven eyes of 188 patients were included in the study. Fifty-eight patients were diagnosed as normal, 130 had glaucoma. OCT had the highest sensitivity and specificity at 70.7% and 76.6%, followed by SAP at 72.4% and 53.5% respectively. Optic-disc photos had the lowest sensitivity and specificity at 55.8% and 54.4% respectively, and the lowest interobserver agreement (kappa = 0.50-0.61). The predictive values of the 3 tests increased to 82% with good interobserver agreement (kappa = 0.68-0.78) when correlated with each other. Conclusion: The correlation of structural and functional tests increased the accuracy of diagnosing glaucoma. These examinations offered complementary information and, when used in conjunction with comprehensive clinical evaluation, guided the clinician in the proper management of patients with glaucoma.https://paojournal.com/index.php/pjo/article/view/319glaucomaoptic-nerve headglaucomatous optic neuropathyoptic-disc photographyoptical coherence tomographystandard achromatic perimetryvisual field |
| spellingShingle | Maria Joanna Rodriguez-Chan, MD Patricia M. Khu,MD,MS Ma. Margarita L. Luna, MD Manuel B. Agulto, MD Correlation of structure and function in glaucoma Philippine Journal of Ophthalmology glaucoma optic-nerve head glaucomatous optic neuropathy optic-disc photography optical coherence tomography standard achromatic perimetry visual field |
| title | Correlation of structure and function in glaucoma |
| title_full | Correlation of structure and function in glaucoma |
| title_fullStr | Correlation of structure and function in glaucoma |
| title_full_unstemmed | Correlation of structure and function in glaucoma |
| title_short | Correlation of structure and function in glaucoma |
| title_sort | correlation of structure and function in glaucoma |
| topic | glaucoma optic-nerve head glaucomatous optic neuropathy optic-disc photography optical coherence tomography standard achromatic perimetry visual field |
| url | https://paojournal.com/index.php/pjo/article/view/319 |
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