Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration
Humerus greater tuberosity (HGT) avulsion fracture is one of the most common types of proximal humerus fractures. The presence of motion and gap lead to the failure of implants, due to the force pulling from the supraspinatus. In this work, electrospinning technology was applied to fabricate PCL-PEG...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1515043/full |
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| author | Zhengyu Cao Hongwu Zhuo Wendong Zhu Xiangfang Peng Jian Li |
| author_facet | Zhengyu Cao Hongwu Zhuo Wendong Zhu Xiangfang Peng Jian Li |
| author_sort | Zhengyu Cao |
| collection | DOAJ |
| description | Humerus greater tuberosity (HGT) avulsion fracture is one of the most common types of proximal humerus fractures. The presence of motion and gap lead to the failure of implants, due to the force pulling from the supraspinatus. In this work, electrospinning technology was applied to fabricate PCL-PEG/CS/AST nanofiber with superior biocompatibility and mechanical property. Furthermore, PCL-PEG/CS/AST nanofiber could promote proliferation and osteogenic differentiation of bone mesenchymal stem cells (BMSCs) in vitro. We believe that this work indicates a promising way to promote the union of HGT avulsion fractures by using PCL-PEG/CS/AST nanofiber. |
| format | Article |
| id | doaj-art-ae3cae3bb08d45a39af7b54b4da5dcd2 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-ae3cae3bb08d45a39af7b54b4da5dcd22025-01-10T06:10:33ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.15150431515043Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regenerationZhengyu Cao0Hongwu Zhuo1Wendong Zhu2Xiangfang Peng3Jian Li4Department of Sports Medicine, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine (FJTCM), Fuzhou, ChinaDepartment of Sports Medicine, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine (FJTCM), Fuzhou, ChinaKey Laboratory of Polymer Materials and Products of Universities in Fujian, Department of Materials Science and Engineering, Fujian University of Technology, Fuzhou, Fujian, ChinaKey Laboratory of Polymer Materials and Products of Universities in Fujian, Department of Materials Science and Engineering, Fujian University of Technology, Fuzhou, Fujian, ChinaDepartment of Sports Medicine, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine (FJTCM), Fuzhou, ChinaHumerus greater tuberosity (HGT) avulsion fracture is one of the most common types of proximal humerus fractures. The presence of motion and gap lead to the failure of implants, due to the force pulling from the supraspinatus. In this work, electrospinning technology was applied to fabricate PCL-PEG/CS/AST nanofiber with superior biocompatibility and mechanical property. Furthermore, PCL-PEG/CS/AST nanofiber could promote proliferation and osteogenic differentiation of bone mesenchymal stem cells (BMSCs) in vitro. We believe that this work indicates a promising way to promote the union of HGT avulsion fractures by using PCL-PEG/CS/AST nanofiber.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1515043/fullelectrospinningnanofiberhumerusbonetuberosity |
| spellingShingle | Zhengyu Cao Hongwu Zhuo Wendong Zhu Xiangfang Peng Jian Li Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration Frontiers in Bioengineering and Biotechnology electrospinning nanofiber humerus bone tuberosity |
| title | Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration |
| title_full | Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration |
| title_fullStr | Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration |
| title_full_unstemmed | Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration |
| title_short | Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration |
| title_sort | rational construction of pcl peg cs ast nanofiber for bone repair and regeneration |
| topic | electrospinning nanofiber humerus bone tuberosity |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1515043/full |
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